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Tailored PEDOT:PSS phase segregation for high-efficiency flexible all-perovskite tandem solar cells and mini-modules
In vivo base editing rescues ADPKD in a humanized mouse model
C1q drives neural stem cell quiescence by regulating cell cycle and metabolism through BAI1
Abstract C1q levels in the CNS are elevated by inflammation and neurovascular trauma, yet the consequence of this increase for neural stem cell (NSC) regeneration response remain unknown. We have recently identified C1q receptor candidates that regulate NSC behavior. One of these is Brain Angiogenesis Inhibitor 1 (BAI1, ADGRB1), which has no previously discovered role in NSC. Here, we show that C1q acts in a BAI1-dependent manner to modulate NSC quiescence via two parallel mechanisms. First, negative regulation of MDM2, driving cell cycle suppression through p53. Second, endocytic internalization of C1q-BAI1-complex, driving regulation of p32 (C1qBP) and metabolic reprogramming towards aerobic glycolysis. We validated the biological significance of BAI1 in a male hNSC line in vivo using a female mouse model of acute spinal cord injury (SCI). These findings are relevant for a multiplicity of CNS disorders, and illuminate complex connections between C1q, cell cycle, and metabolism. Together, these data provide valuable insight into C1q-mediated regulation of NSC transition between activation and quiescence, processes fundamental for tissue development and repair.
Moiré-controllable exciton localization and dynamics through spatially-modulated inter- and intralayer excitons in a MoSe2/WS2 heterobilayer
Planning the electric vehicle transition by integrating spatial information and social networks
Abstract The transition from gasoline-powered vehicles to plug-in electric vehicles (PEVs) offers a promising pathway for reducing greenhouse gas emissions. Spatial forecasts of PEV adoption are essential to support power grid adaptation, yet forecasting is hindered by limited data at this early stage of adoption. While different model calibrations can replicate current trends, they often yield divergent forecasts. Using empirical data from states with the highest levels of adoption in the United States, this study shows that accounting for spatial and social networks among potential PEV adopters produces forecasts that are only one-third of benchmark predictions for 2050. Results further demonstrate that incorporating spatial social networks improves the ability to capture the spatial autocorrelation observed in the empirical diffusion process. This study also evaluates the potential impact of various PEV marketing campaigns under prevailing uncertainties, highlighting the importance of tailoring strategies to network dynamics for effective PEV promotion.
Constructing an anion-capturing interface to achieve Li+ cross-phase transport in composite solid electrolytes
Co-condensation between transcription factor and cBAF selectively modulates chromatin remodeling and gene expression
Analytic Fourier ptychotomography for aberration-free and high-resolution volumetric refractive index imaging
Tailored electrolyte salt anion chemistry for enhanced high-nickel lithium-ion batteries
H3K36 Methylation as a Guardian of Epigenome Integrity
Abstract H3K36 methylation is a key epigenetic mark with critical roles in development and disease. Here, we systematically dissect its functions using CRISPR-engineered mouse mesenchymal stem cells lacking combinations of the five H3K36 methyltransferases, culminating in quintuple knockout cells devoid of H3K36me2/3. We show that H3K36me2 influences enhancer activity, supports the expression of their target genes, and safeguards active genes from encroachment of the repressive marks, H3K27me2/3. In addition, we find that the loss of H3K36me triggers redistribution of large heterochromatic H3K9me3 domains into euchromatin, in part mediated by SUV39H1, leading to global epigenomic remodelling, constitutive heterochromatin erosion, and a collapse of 3D genome organization. Parallel analyses in human HNSCC cells overexpressing the H3K36M oncohistone reveal conserved disruptions to the epigenome and chromatin architecture. Together, these results establish H3K36 methylation as a pivotal regulator of chromatin state and genomic structure.
Metabolomics of saliva, serum, and urine for pathogenesis, diagnosis, and prognosis in gestational diabetes mellitus
Programmable nonlinear quantum photonic circuits
Direct imaging of residual oxygen disorder in an infinite-layer nickelate superlattice via multislice ptychography
Abstract Infinite-layer nickelates have garnered significant attention due to their potential for high-temperature superconductivity. Despite extensive research, the interplay between oxygen stoichiometry and electronic properties in infinite layer nickelates remains inadequately understood. In this study, we employ advanced electron microscopy techniques and theoretical modeling to directly visualize the distribution of residual oxygen within an 8NdNiO 2 /2SrTiO 3 superlattice, providing novel insights into its structural and electronic effects. Our multislice ptychography analysis reveals a disordered arrangement of apical oxygen atoms, even in regions with low residual oxygen occupancy, invisible in conventional projected images but discernible in depth-resolved phase contrast images. This disordered distribution suggests the formation of local domains with varying degrees of oxygenation, leading to significant structural distortions. Electron energy-loss spectroscopy reveals inhomogeneous hole doping in the infinite layer nickelates. Complementary density functional theory calculations show how residual oxygen and associated structural distortions—such as pyramidal and octahedral configurations—alter the electronic structure. Although superconductivity was not observed in the studied superlattice, our findings highlight the critical influence of residual oxygen in shaping electronic phases and suggest that precise control of oxygen stoichiometry is essential in infinite layer nickelates.