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A hybrid ensemble deep learning framework with novel metaheuristic optimization for scalable malicious website detection

Scientific Reports Ting Yang, JiaBao Sun Dec 24, 2025 DOI: 10.1038/s41598-025-33695-z

Abstract The rapid expansion of malicious websites poses a critical threat to online security, as conventional blacklist-based and manual inspection methods cannot keep pace with evolving attacks. In this study, we present a hybrid detection framework that integrates ensemble learning models, Random Forest, Extreme Gradient Boosting, and Light Gradient Boosting with a Deep Neural Network to distinguish malicious from benign websites accurately. The framework leverages a large-scale dataset of 63,191 URLs, combining application-layer attributes (such as URL structure, server type, and WHOIS data) with network-layer features (including TCP exchanges, DNS queries, and packet statistics). Dimensionality reduction is achieved through Principal Component Analysis, while model explainability is provided by SHapley Additive exPlanations. To enhance predictive performance, hyperparameters are tuned using two recent metaheuristic algorithms: the Weevil Damage Optimization Algorithm and the Energy Valley Optimizer. A rigorous k-fold cross-validation strategy confirms the robustness and generalization capability of the model. Experimental results demonstrate that the optimized hybrid framework surpasses individual classifiers, delivering high accuracy, strong scalability, and interpretability. This work contributes to proactive cybersecurity defenses by offering a reliable, data-driven, and explainable solution for real-time malicious website detection.

<i>In situ</i> X-ray Synchrotron Studies Reveal the Nucleation and Topotactic Transformation of Iron Sulfide Nanosheets

Journal of the American Chemical Society Cecilia A. Zito, Lars Klemeyer, Francesco Caddeo et al. Dec 24, 2025 DOI: 10.1021/jacs.5c15843

Asymmetric Synthesis of Diverse P(V) Compounds Bearing a C–P Bond via Desymmetrization of Phosphonic Dichlorides Catalyzed by a Chiral Bicyclic Imidazole

Journal of the American Chemical Society Lu Zhang, Mo Wang, Yicong Luo et al. Dec 24, 2025 DOI: 10.1021/jacs.5c17437

Prognostic value of ultrasonography findings in patients with cervical cancer

Scientific Reports Liuyun Cai, Xiaodong Luo, Chenhuizi Wu et al. Dec 24, 2025 DOI: 10.1038/s41598-025-28187-z

Precision-Engineered Crystalline Covalent Organic Framework Membranes with Staggered ABC Stacking for High-Performance Desalination

Journal of the American Chemical Society Jingsi Yuan, Zhaohuan Mai, Makenna Parkinson et al. Dec 24, 2025 DOI: 10.1021/jacs.5c16195

An experimental investigation of the drift ratio and its influencing factors in mechanical draft wet cooling towers

Scientific Reports Linxiu Qu, Lujun Li Dec 24, 2025 DOI: 10.1038/s41598-025-28273-2

Machine Learning-Assisted Crystal Structure Prediction of Solid-State Electrolytes Reveals Superior Ionic Conductivity in Metastable Edge-Sharing Phases

Journal of the American Chemical Society Ji Hoon Kim, Ji Seon Kim, Yong Hui Kim et al. Dec 24, 2025 DOI: 10.1021/jacs.5c15665

Systematic review of healthcare-led and lay-led interventions for type 2 diabetes in community settings

Scientific Reports Xuanning Luo, Chuanlei Zheng, Qingfeng Wu Dec 24, 2025 DOI: 10.1038/s41598-025-28010-9

Bioactive Artificial Cells as Autonomous Metabolic Actuators Enable Bidirectional Communication with Tumor Cells

Journal of the American Chemical Society Lifan Hu, Wenwu Peng, Jiyao Yu et al. Dec 24, 2025 DOI: 10.1021/jacs.5c14609

Mechanistic insights into DEHP-induced progression of non-small cell lung cancer based on network toxicology and molecular docking

Scientific Reports Zhe Chen, Chi Wang, Yixing Li et al. Dec 24, 2025 DOI: 10.1038/s41598-025-28356-0

Short-Circuiting the SAM-Cycle in <i>Escherichia coli</i>

Journal of the American Chemical Society Zhong Li, Xiaojin Wen, Seseg B. Bolotova et al. Dec 24, 2025 DOI: 10.1021/jacs.5c17370

Promoting Formation and Suppressing Decomposition of H <sub>2</sub> O <sub>2</sub> via Photocarrier Flow at Au@TiO <sub>2</sub> Interfaces

Journal of the American Chemical Society Yicui Kang, Yao Tan, Wenjie Tian et al. Dec 24, 2025 DOI: 10.1021/jacs.5c14650

A lightweight scalable and dynamic blockchain-based model for storing and retrieving patient healthcare records

Scientific Reports Seyed Rahman Soleimani Nadaf, Masood Niazi Torshiz, Sayyed Majid Mazinani et al. Dec 24, 2025 DOI: 10.1038/s41598-025-28337-3

Correction to “Phototheranostic Metal-Phenolic Networks with Antiexosomal PD-L1 Enhanced Ferroptosis for Synergistic Immunotherapy”

Journal of the American Chemical Society Lisi Xie, Jie Li, Guohao Wang et al. Dec 24, 2025 DOI: 10.1021/jacs.5c18626

Saturation and texture geometry effects on plastron longevity on superhydrophobic surfaces

Scientific Reports Md. Abir Hasan Jilan, Estefania Solano-Calderon, Shabnam Mohammadshahi Dec 24, 2025 DOI: 10.1038/s41598-025-28322-w

In Situ Exsolution of High-Density Ni Nanoparticles in LaAl <sub>0.3</sub> Mn <sub>0.2</sub> Ni <sub>0.5</sub> O <sub>3−δ</sub> Cathode for the Electro-Thermocatalytic CO <sub>2</sub> -Intensified Dry Reforming of Methane

Journal of the American Chemical Society Haolin Liu, Shuo Wang, Houfu Lv et al. Dec 24, 2025 DOI: 10.1021/jacs.5c09782

The development of visual acuity and crowding reveals the slow fine-tuning of foveal vision

Scientific Reports John A. Greenwood, Marilia Kyprianou, Tessa M. Dekker Dec 24, 2025 DOI: 10.1038/s41598-025-33169-2

Abstract The adult visual system is characterised by high-resolution foveal vision and a peripheral field limited by crowding, the disruption to object recognition in clutter that gives a summary ‘gist’ over fine detail. In children, crowding is elevated foveally, with the estimated age where foveal crowding drops to adult-like levels varying widely from 5 to 12+ years. As crowding restricts key processes like reading, characterisation of this developmental trajectory is critical. Using methods optimised to measure crowding in children, adults and typically-developing children ( n  = 119; 3–13 years) judged the orientation of a foveal ‘VacMan’ target either in isolation or surrounded by ‘ghost’ flankers. For isolated elements, acuity (measured as gap-size thresholds) dropped rapidly to adult-like levels at 5–6 years. Thresholds rose when flanked/crowded, with elevations highest at 3–4 years, persisting at 5–6 years, and dropping to adult-like levels at 7–8 years. A meta-analysis of our results and 13 prior studies reveals a consistent developmental trajectory, despite wide methodological variations. We further demonstrate that developmental crowding shows the same selectivity for target-flanker similarity as peripheral crowding, consistent with common mechanisms. This prolonged development reveals a shifting balance in the visual system between the processing of fine detail vs. the ‘gist’ of the scene.

High-Entropy Double Perovskites with Tailored Multichannel Luminescence

Journal of the American Chemical Society Jie Xue, Jun Luo, Kin Ting Chang et al. Dec 24, 2025 DOI: 10.1021/jacs.5c18097

Enhancement of wheat seed germination using double dielectric barrier discharges with electrodes immersed in a conductive liquid

Scientific Reports C. Amado, P. G. Reyes, A. Gómez et al. Dec 24, 2025 DOI: 10.1038/s41598-025-28066-7

Atomic-Scale Engineering of <i>d–</i> π– <i>d</i> Spin Interaction in Metal–Organic Architectures

Journal of the American Chemical Society Xue Zhang, Xin Li, Jie Li et al. Dec 24, 2025 DOI: 10.1021/jacs.5c18517