Browse Articles

Electric-Field-Controlled Altermagnetic Transition for Neuromorphic Computing

Association between triglyceride-glucose index and depression in middle-aged and older adults with hypertension: insights from the CHARLS study

Water Microdroplets Transform Reducing Sugars into a Platform Chemical 5-Hydroxymethylfurfural

Phase contrast CMR in the descending aorta as a supportive reference for severe aortic regurgitation

Abstract Accurate grading of aortic regurgitation (AR) severity is crucial for treatment decisions. This study aimed to determine whether phase contrast cardiac magnetic resonance (PC-CMR) in the descending aorta can be used as a supporting reference for grading of the AR severity in patients with chronic AR. PC-CMR was performed both in the ascending and descending aorta of 191 AR-patients. Regurgitation thresholds in the descending aorta for hemodynamically significant AR [regurgitation volume (RVol) DA and fraction (RF) DA ] were determined in 41 well-controlled patients and then validated in a cohort surveyed for AR in our clinic. Myerson’s outcome-based thresholds (RVol > 42 mL, RF > 33%) served as reference. For comparison, holodiastolic flow reversal (HFR) was determined. Regurgitation measurements in the descending and ascending aorta were strongly correlated (RVol: R  ≥ 0.92; RF: R  ≥ 0.85; p  < 0.001). Diagnostic performance of RVol DA >17 mL and RF DA >23% was high (sensitivity: 92%, 83%; specificity: 95%, 93%) and more patients with significant AR were identified using these PC-MRI based thresholds [RVol DA >17mL (13%) and RF DA >23% (15%)] than with HFR alone. PC-CMR in the descending aorta has the potential to reliably grade AR severity in patients with chronic AR and thereby may serve as a supportive reference in the decision-making regarding optimal timing of intervention.

Covalent Bridges Enabling Layered C ₆₀ as an Exceptionally Stable Anode in Lithium-Ion Batteries

Elucidating the anti-fibrotic mechanisms of Abrus cantoniensis in hepatic fibrosis using network pharmacology and proteomics

Using Solid-State NMR to Understand the Structure of Plant Cellulose

Agreement and repeatability of a novel portable transpalpebral tonometer for home tonometry versus non-contact and rebound tonometry

Symmetry Breaking Charge Separation in Zinc Phthalocyanine Dimers Self-Assembled via Hydrogen Bonding

Cancer neuroscience: illuminating the neural dimension of tumor biology

Assessment of stability and yield performance of onion (Allium cepa L.) genotypes across diverse Indian environments

Electrochemical Dehydroxymethylative Functionalization of Unactivated Alcohols via Criegee–Kolbe Radical Relay

Heat-resistant cementitious composites based on binders derived from cement and metallurgical waste

Enantioselective Ni–Al Bimetal-Catalyzed Cycloaddition of Cyclopropyl Ketones with Alkynes under Mild Conditions

The association between amyloid-beta deposition on dual-task gait performance is partially moderated by cognitive functions in healthy older adults

Determination of Thermochemical Barriers in Multiple-Collision-Induced Dissociation Experiments on Gas-Phase Protein Complexes

Lightweight YOLO object detectors for PET and HDPE classification in recycling facilities

Elucidating Electronic Coupling of Bimolecular Excited State Electron Transfer

Enhancing graph transformer encoding with graph heterogeneous memory for improved recommendation performance

Catalytic Enantioselective Cross-Nucleophile Coupling via Valence Tautomerism