Browse Articles

Spatial Dynamics of the Fermi Level in Electrolyte-Gated Graphene

Probing the Conformation of BamC and BamE in Native Bacterial Membranes Using Solid-State NMR Spectroscopy

Interplay of Redox Non-Innocence and Symmetry Breaking in a 4d Coordination Framework

Spatiotemporally Controlled NIR-II Afterglow Nanoprobes via Synergistic Ultrasound and Peroxynitrite-Induced Energy Transfer for Precision Theranostics

Structural Heterogeneity and Hydrodynamics of an Intrinsically Disordered Protein Condensate

Coordination-Isomerism-Driven Threshold Pressure Control of CO ₂ and C ₂ H ₂ in Mixed-Ligand Switching Metal−Organic Frameworks

Beyond Thiol-Enzyme Inhibition: Sterically Bulky NHC-Au(I) Complexes are Catalytically Active Anticancer Agents with Reprogrammed Immunomodulatory Function

Dibenzocyclooctyne Conjugation Enhances Antigen Cross-Presentation and T-Cell Killing for Potent Cancer Vaccines

Enriching Local Reaction Fields via Ordered Multidimensional Interfaces for High-Yield Urea Electrosynthesis

Secondary Structure-Encoded Control of Lipid Assembly by Radially Amphiphilic Peptides

Automerization of Cyclobutadiene: Multiconfiguration Pair-Density Functional Theory Gives High Accuracy Where Unrestricted Kohn–Sham Density Functional Theory Does Not

Correction to “Detection of Mutation-Induced Conformational Changes in an Intrinsically Disordered Protein by Double Quantum Coherence Electron Spin Resonance Methodology”

Electroacupuncture-Activated Mitochondria-Targeted Polymeric Radicals for cGAS-STING-Activated Immunotherapy

Precise Optical Modulation of Charge Transport in 2D Organic Molecular Crystals through Tailor-Designed Photoswitchable Guest–Host Architectures

Chronic Pain and Cognitive Dysfunction: Clinical Implement, Mechanism, and Therapeutic Strategy

Chronic pain (CP) is increasingly recognized not only as a sensory and emotional condition but also as a significant contributor to cognitive dysfunction. Growing evidence indicates that CP-induced cognitive dysfunction arises from a cascade of neurobiological processes, including persistent neuroinflammation, neurotransmitter dysregulation, and impaired synaptic plasticity. These mechanisms particularly affect the hippocampus and medial prefrontal cortex (mPFC)—regions essential for memory, attention, and executive function. Neuroimaging studies have documented structural atrophy and disrupted network connectivity in these brain areas in CP patients. At the molecular level, pro-inflammatory cytokines such as interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) impair glutamatergic and GABAergic signaling, disrupt long-term potentiation (LTP), and inhibit neurogenesis. Additionally, dysregulation of brain-derived neurotrophic factor (BDNF) signaling exacerbates synaptic vulnerability, contributing to cognitive decline. These mechanistic overlaps are particularly relevant in aging populations and in Alzheimer's disease (AD), where CP may act as a risk factor. This review integrates clinical and preclinical findings on CP-related cognitive dysfunction, outlines key molecular mechanisms, and explores emerging therapeutic strategies targeting inflammation, neurotransmitter systems, and synaptic repair. Understanding the interaction between chronic pain and cognition is critical for developing precision treatments that address both nociceptive and neurodegenerative pathways.

Positive, But Not Negative, Emotion Retroactively Enhances Memory via Neural Reactivation

Aeromagnetic analysis of the shear zones of Ambaji garnulite, NW India: implications for base-metal mineralization

Electride-Stabilized Iridium Nanoparticles with Subsurface Oxygen Confinement for Oxygen Evolution Electrocatalysis

Evaluation of the level of responsibility in pedestrian crashes using machine learning algorithms

Study on the strength properties of coir fiber reinforced concrete containing waste brick powder dust as sand replacement