Browse Articles
Discover research articles across all indexed journals
FMCL: a transformer-based feature-map classifier learning approach for enhanced brain tumor detection in MRI
Network toxicology study and key target validation of chlorpyrifos-induced nonalcoholic fatty liver disease
Projected intensification of precipitation extremes in the Kosi Basin using CMIP6 models
Real-Time stability enhancement of DDPMSG-based tidal hybrid power systems using heuristic optimization
Abstract In this research, we analyze the optimal configuration and stability issues associated with a tidal hybrid power system employing a Direct Drive Permanent Magnet Synchronous Generator (DDPMSG). The Tidal system has become unstable since the natural tidal pattern and wind power input have been disturbed. The use of a controller for the Unified Power Flow Controller (UPFC) makes the system stable. Stability analysis, which uses Eigen and Nyquist plots, is used to see how well the proposed controllers work. Additionally, it is evident that the regulator can be effectively calibrated when the variables significantly influence the system’s performance. So, to find the best output for the suggested controller, it is best to use heuristic optimization methods like the Differential Evolution Algorithm (DEA) and the Firefly Algorithm (FA), followed by hybrid FA. The results indicate that the hybrid FA-based system demonstrates enhanced stability, evidenced by increased performance in settling time, rising time, peak overshoot, and damping. The performance and durability assessment of the controller in question is executed using real-time data via OPAL-RT 5142, a digital simulation platform tailored for real-time applications.
Aerobic exercise-induced irisin secretion is associated with improved endothelial function and reduced atherosclerosis in ApoE-deficient mice
Sex and BMI as predictors of pill residue in dysphagia: a multivariate analysis
Abstract We aimed to explore the specific challenges encountered by individuals with dysphagia when taking oral medications, focusing on the types of dysphagia that impede pill swallowing and the relationship between body mass index (BMI) and pill residue. We retrospectively reviewed 70 patients who underwent videofluoroscopic swallowing studies at the Department of Dysphagia Rehabilitation, Tokyo Medical and Dental University Dental Hospital between May 2013 and March 2020. Patients were assessed for pill residue in various anatomical locations, including the mouth, epiglottic vallecula, and piriform sinus. Patient demographics, BMI, functional oral intake scale scores, and clinical histories were collected. Pill residue was most commonly observed in the epiglottic vallecula (17% of patients), followed by the piriform sinus (10%) and mouth (9%). Males were more likely to have tablet residue in the epiglottic vallecula ( p = 0.047), and a lower BMI was associated with increased pill residue in the piriform sinus ( p = 0.025). Multivariate analysis identified sex as a significant predictor of epiglottic pill residue ( p = 0.031), whereas a lower BMI was associated with pill residue in the piriform sinus ( p = 0.016). Sex and BMI significantly influenced pill residue in patients with dysphagia; males and individuals with a lower BMI (< 18.5 kg/m 2 ) were at higher risk.
Innovative Aboodh-based gractional analytical methods for nonlinear Burgers’ partial differential equations
Machine learning framework for multidimensional assessment of urban quality of life
Thermo-mechanical modelling and experimental production of aluminium circular form detail using three-level hierarchical WAAM model
Force sensorless interaction wrench estimation for neural-learning impedance control of a flying parallel robot with actuator saturation
Statin use and the risk of liver-related events in older adults with steatotic liver disease
Effects of a Pringle maneuver on jejunal mucosal oxygenation and blood flow in a porcine model
Dielectric function of layered GaSe0.8Te0.2 and emergent all van der Waals optical elements
Clinical relevance of circulating blood microaggregates and reactivation of Epstein Barr Virus in long-term Post-CoVID syndrome patients
Immunotolerant Oligomer scaffolds promote regenerative remodeling and improved muscle structure and function after volumetric muscle loss
Ramadan fasting and adverse outcomes in cirrhosis: primary risk estimates with associated independent predictors
GV1001 reduces pathological 4R tau and functional deficits in models relevant to progressive supranuclear palsy
Abstract GV1001, a peptide drug derived from human telomerase reverse transcriptase, has showed the therapeutic effect in the animal model of Alzheimer’s disease (AD), a representative chronic neurodegenerative disease having impaired learning and memory. In our previous studies, GV1001 has showed the multi-functions including anti-apoptosis, anti-oxidative stress, and anti-neuroinflammation in AD-related in vitro and in vivo systems. Here, in addition to these previously reported functions, GV1001 was discovered to reduce the protein level of 4R tau isoform in the pathological condition. There is no studies providing the potential of GV1001 as a therapeutic drug for neurodegenerative movement disorders. Progressive supranuclear palsy (PSP) is a rare atypical Parkinsonism in the midbrain region, leading to more severe motor symptoms and very rapid pathological progression. Increased 4R tau isoform in an affected brain region of the primary 4R tauopathy is a distinct pathological character in PSP patients. In this study, GV1001 down-regulated the protein level of 4R tau specifically in an annonacin-induced PSP in vitro neuronal model as well as in vivo study using 4R TauP301L-BiFC mouse model. These findings suggest a novel role of GV1001 in 4R tauopathy and support its disease-modifying potential within the context of 4R tau–driven neurodegenerative models, including PSP.