Browse Articles

Dream Team

Strategic synthesis of FLPClusters toward catalysis

Vulvar Melanoma with Vaginal Extension

NAA40 and NAC cooperate in co-translational histone acetylation in humans

Abstract N-terminal acetylation is an abundant and predominantly co-translational modification in eukaryotes that profoundly affects folding, compartmentalization fidelity and turnover of target proteins. Unlike other N-acetyltransferases, human NatD is composed solely of the catalytic subunit NAA40 and exclusively modifies histone proteins H2A and H4. However, the molecular details of co-translational NAA40 activity have remained elusive. Here, we show biochemically and by cryo-EM how NAA40 activity is coordinated at the ribosomal peptide tunnel exit involving the NAC complex. We demonstrate that the NAA40-NAC interaction is required for efficient ribosome binding and histone acetylation. Furthermore, we provide insights on the potential coordination of methionine removal and subsequent NAA40-mediated acetylation by formation of a multienzyme complex on the ribosome involving METAP1. Therefore, our results illustrate the details of N-terminal histone acetylation by NAA40 and highlight the role of NAC as a general coordinator of nascent protein modification.

DB-OTO Gene Therapy for Inherited Deafness

Urban forestry for cooler cities faces three critical hurdles

Case 8-2026: A 57-Year-Old Woman with Chest Pain, Dyspnea, and Syncope

A large-scale coherent 4D imaging sensor

VHL synthetic lethality screens uncover CBF-β as a negative regulator of STING

Abstract Clear cell renal cell carcinoma (ccRCC) represents the most common form of kidney cancer and is typified by biallelic inactivation of the von Hippel-Lindau ( VHL ) tumour suppressor gene. Here, we undertake genome-wide CRISPR/Cas9 screening to reveal synthetic lethal interactors of VHL , and uncover that loss of Core Binding Factor β (CBF-β) causes cell death in VHL -null ccRCC cell lines and impairs tumour establishment and growth in vivo. This synthetic relationship is independent of the elevated activity of hypoxia inducible factors (HIFs) in VHL -null cells, but does involve the RUNX transcription factors that are known binding partners of CBF-β. Mechanistically, CBF-β loss leads to upregulation of type I interferon signalling, and we uncover a direct inhibitory role for CBF-β at the STING locus controlling Interferon Stimulated Gene expression. Targeting CBF-β in kidney cancer both selectively induces tumour cell lethality and promotes activation of type I interferon signalling.

The Cell and Gene Therapy Access Model — A Vision for Future Development

Mode hopping via nonlinear magnon-magnon coupling in a synthetic antiferromagnet

Current and Emerging Approaches to Evaluating Influenza Vaccine Performance

Millennial-to-orbital-scale subsurface ocean warming and Polynya formation off Dronning Maud Land during the last glacial

Abstract We present a millennial-scale multi-proxy reconstruction of changes in properties of the upper water column near the East Antarctic ice shelf based on planktonic foraminifera from a unique sedimentary archive spanning the glacial period from 75,000 to 20,000 years. Our results imply that variations in the thermohaline structure between Antarctic Surface Water and Warm Deep Water (WDW) may have resulted in either strengthening the stratification of the upper water column or promoting polynya formation (convective overturning). Oceanic subsurface warming during glacial Antarctic stadials and periods of low obliquity, combined with increased salinity and nutrient content, suggests the breakdown in stratification and polynya presence. This glacial polynya formed off Dronning Maud Land (DML) reflects a hybrid coastal-open-ocean polynya mode. We attribute the development of the Glacial DML Polynya to sea-ice induced subsurface warming of WDW and a decrease in density stratification in combination with circulation changes in the atmosphere and ocean. The polynya-driven oceanic heat release during the glacial stadials may have increased the moisture supply to Antarctica and thus promoted the accumulation of ice and the thickening of an advancing ice sheet at the continental shelf margin.

Good Compressions

Photonic ‘ski jump’ steers light beam from silicon chip

Dual-stiffness nanoparticles for compartment-specific drug delivery in stroke

Health Consequences of Immigration Enforcement in U.S. Communities

Volatile resorption expedites eruption onset in large silicic systems

Abstract Silicic caldera-forming eruptions are among the most hazardous natural phenomena on Earth, yet their triggering mechanisms remain poorly understood. While volatile exsolution is widely recognized as a potential eruption driver in large silicic systems, we find that volatile resorption can, counterintuitively, promote chamber pressurization faster than volatile exsolution. Using a thermo-mechanical magma chamber model, we show that resorption is a common process in rapidly recharged systems, driven by pressure increase and crystal melting. The Aso-4 eruption offers a natural case where volatile resorption may have occurred, with model results predicting resorption at recharge rates >10 -2.4 km 3 /yr. Through reducing bulk magma compressibility, resorption amplifies pressurization, driving chamber destabilization and potentially expediting eruption onset. Here, we propose that volatile resorption is a natural process both accommodating and promoting rapid chamber pressurization, fundamental to destabilizing large-scale silicic systems. Detecting its signatures in monitoring signals could provide early warning of imminent eruption.

Thrombopoietin-Receptor Agonists in Chemotherapy-Induced Thrombocytopenia

Matrix stress relaxation promotes glioblastoma cell migration in a ligand-specific manner