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Understanding cholestatic itch

Nature Reviews Drug Discovery Sarah Crunkhorn Jan 01, 2025 DOI: 10.1038/d41573-024-00191-4

FDA approves first biparatopic antibody therapy

Nature Reviews Drug Discovery Asher Mullard Jan 01, 2025 DOI: 10.1038/d41573-024-00189-y

Author Correction: B cell depletion therapies in autoimmune disease: advances and mechanistic insights

Nature Reviews Drug Discovery Dennis S. W. Lee, Olga L. Rojas, Jennifer L. Gommerman Jan 01, 2025 DOI: 10.1038/s41573-024-01103-2

FDA approves second TTR stabilizer for cardiac amyloidosis

Nature Reviews Drug Discovery Asher Mullard Jan 01, 2025 DOI: 10.1038/d41573-024-00188-z

Metabolic control of luteinizing hormone-responsive ovarian steroidogenesis

Journal of Biological Chemistry Emilia Przygrodzka, Fatema Bhinderwala, Robert Powers et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108042

StitchR platform joins up gene therapy payloads

Nature Reviews Drug Discovery Katie Kingwell Jan 01, 2025 DOI: 10.1038/d41573-024-00186-1

High-affinity ELR+ chemokine ligands show G protein bias over β-arrestin recruitment and receptor internalization in CXCR1 signaling

Journal of Biological Chemistry Katrijn Boon, Nathan Vanalken, Martyna Szpakowska et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108044

NK2R agonist delivers one-two punch to obesity

Nature Reviews Drug Discovery Sarah Crunkhorn Jan 01, 2025 DOI: 10.1038/d41573-024-00185-2

Structural basis for Rab23 activation and a loss-of-function mutation in Carpenter syndrome

Journal of Biological Chemistry Yat Yin Chau, Hanbin Liang, Wai Lam Tung et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108036

An SH3-binding allosteric modulator stabilizes the global conformation of the AML-associated Src-family kinase, Hck

Journal of Biological Chemistry Ari M. Selzer, Gabriella Gerlach, Giancarlo Gonzalez-Areizaga et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108088

FDA approves l-amino acid decarboxylase deficiency gene therapy

Nature Reviews Drug Discovery Asher Mullard Jan 01, 2025 DOI: 10.1038/d41573-024-00184-3

Prohibitin 1 tethers lipid membranes and regulates OPA1-mediated membrane fusion

Journal of Biological Chemistry Tadato Ban, Kimiya Kuroda, Mitsuhiro Nishigori et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108076

Senescence as a therapeutic target in cancer and age-related diseases

Nature Reviews Drug Discovery Domhnall McHugh, Imanol Durán, Jesús Gil Jan 01, 2025 DOI: 10.1038/s41573-024-01074-4

Apoptotic signaling by TNFR1 is inhibited by the α2-6 sialylation, but not α2-3 sialylation, of the TNFR1 N-glycans

Journal of Biological Chemistry Jihye Hwang, Tejeshwar C. Rao, Jiahui Tao et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108043

DNA damage response inhibitors in cancer therapy: lessons from the past, current status and future implications

Nature Reviews Drug Discovery Yvette Drew, Frank T Zenke, Nicola J Curtin Jan 01, 2025 DOI: 10.1038/s41573-024-01060-w

Aberrant Wnt/β-catenin signaling in the mesenchymal stem cells of LZTFL1-depleted mice leads to increased adipogenesis, with implications for obesity

Journal of Biological Chemistry Yunden Badralmaa, Ven Natarajan Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108057

The state-of-the-art of N-of-1 therapies and the IRDiRC N-of-1 development roadmap

Nature Reviews Drug Discovery Anneliene H. Jonker, Elena-Alexandra Tataru, Holm Graessner et al. Jan 01, 2025 DOI: 10.1038/s41573-024-01059-3

The mode of subunit addition regulates the processive elongation of actin filaments by formin

Journal of Biological Chemistry Biswaprakash Mahanta, Naomi Courtemanche Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108071

Two decades of new drug approvals in Japan

Nature Reviews Drug Discovery Ryosuke Kuribayashi, Aya Hariu, Yasuhiro Kishioka et al. Jan 01, 2025 DOI: 10.1038/d41573-024-00153-w

Small molecule-based regulation of gene expression in human astrocytes switching on and off the G-quadruplex control systems

Journal of Biological Chemistry Vijay Kumar M. J, Jérémie Mitteaux, Zi Wang et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108040