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Discover research articles across all indexed journals
Reconstitution of Ras-PI3Kγ membrane communication and feedback using light-induced signaling inputs
Balancing the Scales — Extended DAPT in Coronary Artery Disease
Moderate volcanic eruptions and extreme wildfires humidify the stratosphere
NSF bans almost all research collaborations with China
Agency drops attempt to mitigate risk in favor of outright prohibition on working with most Chinese research institutions
High-voltage and high-safety lithium-ion batteries enabled by nonflammable electrolyte with enhanced Li+ desolvation behavior
The Exam Room as Sanctuary — Caring for Undocumented Patients
Production and spectroscopy of cold radioactive molecules
Molecules with heavy, radioactive nuclei promise extreme sensitivity to fundamental nuclear and particle physics. However, these nuclei are available in limited quantities, which challenges their use in precision measurements. Here we demonstrate the gas-phase synthesis, cryogenic cooling, and high-resolution laser spectroscopy of radium monohydroxide, monodeuteroxide, and monofluoride molecules ( 226 RaOH, 226 RaOD, and 226 RaF) in a tabletop apparatus by combining trace radioactive target production protocols, optically driven chemistry in a cryogenic buffer gas, and low-background spectroscopic detection methods. The molecules are cooled in the lab frame, creating conditions that are the same starting points as those for many current molecular precision measurement and quantum information experiments. This approach can be readily applied to a wide range of species and establishes key capabilities for molecular quantum sensing of exotic nuclei.
Continuous or Fixed-Duration Maintenance Therapy in Multiple Myeloma
Social calibration of sycophantic AI
Case 20-2026: A 38-Year-Old Man with Abdominal Pain
A prognostic human brain network for diffuse midline glioma
Abstract Diffuse midline gliomas (DMGs) are near-universally lethal tumours of the childhood central nervous system 1,2 . In animal models, DMGs form brain-wide integrated networks through neuron-to-glioma synapses 3–6 and glioma-to-glioma gap junctional coupling 3 . This extensive connectivity robustly promotes the growth and invasion of DMG 3–9 and other glial malignancies 10–12 through paracrine mechanisms and direct neuron-to-glioma synapses. However, the organization and clinical implications of these connections in the living human brain remain to be elucidated. Here, we develop tumour network mapping to compute the brain-wide connectivity profile of DMG, defining a conserved brain network across pontine and thalamic DMG associated with patient short-term survival (DMG network). Tumour functional connectivity with the DMG network was independently predictive of patient overall survival across two external validation cohorts. Tumour growth mapped to DMG network-specific trajectories and peak in-network neurometabolic changes across development spatiotemporally aligned with the peak age incidence of DMG. Analyses of single-nucleus RNA sequencing data confirmed diverse synaptic gene enrichment in high-connectivity DMG. Strikingly, incidental surgical resection of high-connectivity thalamic DMG tissue conferred a significant survival advantage. Collectively, these data define a conserved and prognostically important brain network in children with DMG, consistent with the hypothesis that DMGs exploit otherwise healthy brain circuits to promote tumour growth.
Dendritic cells control tertiary lymphoid structure development and maintenance in cancer
Tertiary lymphoid structures (TLSs) are associated with immunotherapy response, yet the mechanisms controlling their formation and maintenance remain unclear. Using spatial transcriptomics and multiplex imaging across human tumors, we found that CCR7 + mature dendritic cells (DCs) accumulate in TLSs. In a mouse non–small cell lung cancer model that forms mature TLSs, we show that early TLS development requires interferon-γ (IFN-γ)–driven type 1 conventional dendritic cell (cDC1) maturation, migration to tumor-draining lymph nodes (tdLNs), and T cell recruitment. As tumors progress, TLSs persist independently of tdLN T cell egress, coinciding with cDC1 accumulation within intratumoral CCL19 stromal hubs. There, cDC1–major histocompatibility complex class 1 (MHC-I) and –MHC-II concomitant antigen presentation, along with CD40 signaling, sustain TLS, T follicular helper (T FH ) cell pool, germinal centers, and tumor-specific immunoglobulin G (IgG). These findings highlight local mature cDC1s as key TLS orchestrators and potential targets to enhance antitumor TLS function.
Extended Dual Antiplatelet Therapy for Multivessel Coronary Artery Disease
Paper mill cancer studies get double the number of citations as genuine papers
The Therabot will see you now
Generative artificial intelligence can scale precision evidence-based psychotherapy
Supporting Access to Reliable Health Information with Public–Private Collaboration
De novo design of orthogonal far-red, orange, and green fluorophore-binding proteins for multiplexed imaging
Fluorescent proteins and small-molecule dyes offer complementary advantages for biological imaging: proteins are amenable to genetic tagging, whereas dyes provide superior brightness and photostability. To combine these strengths, we used de novo protein design to generate small, nanomolar-affinity, high-selectivity binders (NovoTags) for three cell-permeable dyes spanning the visible spectrum. We show that the NovoTag fluorescent lifetimes can be tuned and demonstrate their application in lifetime and wavelength-based multiplexed fluorescence imaging. We further design a two-chain NovoTag that functions as a chemically induced dimerization system with fluorescent readout in living cells, or as a minimally perturbing proximity probe in fixed cells. Our approach combines the advantages of fluorescent proteins and small-molecule dyes, expanding the toolkit for cellular imaging.
The Symptom Tracker
Bringing radioactive molecules to the table
A compact source of radioactive molecules could enable new tests of fundamental physics