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Multimodal magnetic resonance imaging of the vastus medialis for quantitative diagnosis and grading in early-stage knee osteoarthritis and its correlation with severity
Automated weed segmentation with knowledge based labeling for machine learning applications
Whole-transcriptome identification of deleterious variants in candidate genes linked to bovine paratuberculosis
Fecal carriage and molecular characterization of ESBL-producing Enterobacteriaceae among farmers in Mid-Western Uganda
An improved black-winged kite algorithm for solving non-lethal kinetic strike parameters for moving targets
Multimodal fault detection model for photovoltaic modules
Prospective pilot randomized controlled study of mini-scleral lenses versus rigid gas permeable lenses in irregular cornea with dry eye
An integrative clinical and bioinformatic analysis identifies MicroRNAs as biomarkers of ischemic stroke severity
Screening oral health in older adults: accuracy of the Oral Health Screener for use within the interRAI
Intelligent generation of product bionic image forms via multimodal emotion-weighted quantification
Elite elimination osprey optimization algorithm optimized kernel extreme learning machine for bankruptcy prediction problems
Nutritional and phytochemical properties of Pakhoi a traditional fermented beverage from Uttarakhand, India
Unveiling advanced green assessment of simple and cost effective spectrophotometric determination of domperidone and pantoprazole for gastrointestinal disorders
Abstract In the pursuit of sustainable pharmaceutical analysis, Green Analytical Chemistry emerges as a vital approach to protect both human health and the environment. This study focuses on a green analytical approach for the simultaneous evaluation of Domperidone (DP) and Pantoprazole (PP), two widely used gastrointestinal drugs with distinct mechanisms and therapeutic roles. A suite of advanced spectrophotometric techniques, including the Deconvoluted Fourier method (DF), the Dual Wavelength method (DW), and both First-Order Derivative (D 1 ) and Second-Order Derivative (D 2 ) methods, was developed for the simultaneous determination of DP and PP. The linearity ranges were found to be (1.0– 9.0) µg/mL for both drugs; this range applies to all the proposed methods. Accuracy and reliability were confirmed via the standard addition technique. Furthermore, the performance of the suggested approaches was statistically compared with that of previously reported HPLC methods, showing their efficiency, eco-friendliness, and practical applicability. The methods were applied to laboratory-prepared combinations with varying concentrations of the two drugs to evaluate selectivity, as well as to their commercially available dosage forms. These methods were rigorously assessed for their environmental sustainability using green analytical chemistry metrics: The Analytical Eco-Scale, the Modified Green Analytical Procedure Index (MoGAPI), the Analytical Green Star Area (AGSA), Carbon footprint (CaFRI), Blueness evaluation using BAGI tools, Click Analytical Chemistry Index (CACI) and the Multi-Color Assessment (MA) Tool.