Browse Articles

Olezarsen for Managing Severe Hypertriglyceridemia and Pancreatitis Risk

Correction: Slower respiration rate is associated with higher self-reported well-being after wellness training

A 12,000-Year-Old Case of <i>NPR2</i> -Related Acromesomelic Dysplasia

The proprioception illusion can simulate limb movement in persons with limb difference

CORE Principles in the Management of Severe Hypertriglyceridemia

The interplay of grit, resilience, and burnout among medical students during exams: a cross-sectional study in Mansoura university, Egypt

Abstract Medical students experience significant burnout during exams, underscoring the need for factors that can buffer its impact. Thus, this cross-sectional study examined the relationship between grit, resilience, and burnout among Mansoura University medical students during the January 2025 exam period. Following a pilot study, an online survey distributed via the faculty’s official student platforms using convenience sampling collected responses from 653 students. Participants completed the Burnout Assessment Tool (BAT-23), Short Grit Scale (Grit-S), and Brief Resilience Scale (BRS). Pearson correlations assessed bivariate relationships, and multivariable linear regression identified independent predictors of burnout. Mean total burnout was 3.62 (range 1–5), and subdomain means were highest for exhaustion (3.96) and cognitive impairment (3.66). Burnout correlated negatively with grit ( r  = − 0.595, p  &lt; 0.001) and resilience ( r  = − 0.519, p  &lt; 0.001); grit and resilience were positively correlated ( r  = 0.426, p  &lt; 0.001). In multivariable regression analysis, both grit (Unstandardized Beta (B) = -0.46, 95% Confidence Interval (CI) [-0.52, -0.39]) and resilience (B = -0.32, 95% CI [-0.38, -0.25]) were independently associated with lower burnout. These findings highlight grit and resilience as significant protective factors against burnout among medical students during exams.

Inheritance

Psychological and cognitive-emotional moderators of suicidal ideation and self-harm in young adults

Abstract The risk for suicide has been conceptualized as a continuum from dysfunctional psychological and cognitive states to suicidal thoughts and behaviour. Little is known about risk and protective factors along the continuum. In the current study, we assessed ninety-four university students (36 individuals indicated suicidal ideation and 33 reported self-harm) for suicidality, depression, entrapment, defeat, hopelessness, mindfulness, self-compassion, and implicit associations with death/suicide. We used regression models and moderation analyses to test if mindfulness, self-compassion, and implicit association with death/suicide related to suicidal ideation, self-harm, entrapment, or moderated the hypothesized continuum from entrapment to suicidal ideation and from entrapment to self-harm. Analyses were corrected for the severity of depressive symptomatology. Results indicated that lower self-compassion and weaker implicit associations with death/suicide were statistically associated with self-harm, but not suicidal ideation. Mindfulness is trend-wise associated with entrapment and moderated the relation between entrapment and suicidal ideation. Self-compassion nor implicit associations with death/suicide moderated the relation between entrapment and suicidal ideation. Hence, lower self-compassion and weaker implicit associations with death/suicide seem directly related to suicide risk behaviour, whereas mindfulness appears to negatively (i.e., suggestive of a protective role) relate to psychological risk-states earlier in the continuum. Therefore, self-compassion and mindfulness seem promising prevention targets for suicide risk in young adults.

Aggressive Lymphoma after CD19 CAR T-Cell Therapy

Multidimensional strategy enables scalable metabolome diversity in microbial fermentations

Abstract Natural products (NPs) are critical sources of new drug leads, but their biosynthesis is highly sensitive to bioprocess parameters and environmental conditions, making NP discovery especially susceptible to challenges in achieving robust scalability and reproducibility of the metabolome across various cultivation systems. Here, we identified key factors that improved the metabolic footprint overlap of Streptomyces griseochromogenes across three cultivation systems, i.e. baffled shake flasks (BSF), 48 flower plates (48 FP), and a stirred tank bioreactor (STR), by 50 %. Using the classical scale-up criterion of constant oxygen availability, the metabolic footprints were found to differ considerably, with only an 18 % overlap in mass feature (MF) number. Efforts to improve overlap by varying ethanol concentration in culture medium and oxygen availability resulted in an 18 % increase. Factor analysis of 80 cultivations including variations in bioprocess conditions, growth, and MF detection identified morphology and total MF number, mainly influenced by the cultivation systems, as key factors in metabolic footprint reproducibility. Molecular network analysis revealed that 48 FP and STR share the highest number of molecular clusters. Our findings reveal that only multidimensional optimization unlocks robust metabolome scalability and reproducibility across cultivation systems, paving the way for the discovery of novel NPs.

Baker’s Cyst

Cause of vision loss discovered in overlooked genes

Synergistic tribo-mechanical enhancement of heat-cured poly(methyl methacrylate) denture base via hybrid in-situ synthesized organic and inorganic nanoparticles

Abstract Poly(methyl methacrylate) (PMMA) is the primary material for dental applications, but it suffers from limitations such as poor wear resistance and long-term durability. To address these shortcomings, this work presents a new and cost-effective hybrid nanofiller system comprising hydroxyapatite (inorganic nanoparticles) and date seed (organic nanoparticles) for reinforcing PMMA denture bases. This study specifically investigates the reinforcement of heat-polymerized PMMA with this new hybrid nanofiller. Comprehensive material characterization was performed using XRD, DSC, SEM, TEM, and EDX. The findings demonstrate that PMMA composites with 0.2-1 wt% hybrid nanoparticles, particularly at 0.6 wt%, showed enhanced mechanical and tribological performance compared to the pure polymer. Specific improvements included a 30.99% decrease in the coefficient of friction, a 37.39% reduction in wear rate, a 31.92% increase in compressive strength, and a 9.87% improvement in surface hardness.

Mental Health Outcomes in Children after Parental Firearm Injury

Patient-level CAD-RADS scoring from coronary radiomic features

Canny cattle: at least one cow knows how to use tools

Porphyrin-nitrogen carbon dot composites for high-performance organic light-emitting diodes

Abstract Fluorescent organic light-emitting diodes (OLEDs) still face major obstacles to combining high efficiency with solution processability and energy-sustainable operation. In this work, a tetra-carboxyphenyl porphyrin–nitrogen carbon dots (TCPP-NCDots) derivative is introduced as a solution-processable electron transport layer (ETL) in OLEDs based on a green–yellow emissive polymer. The structural, optical, and electronic properties of the TCPP-NCDots ETL are comprehensively characterised by ultraviolet–visible absorption spectroscopy, steady-state photoluminescence, Fourier-transform infrared spectroscopy, atomic force microscopy, and cyclic voltammetry. These studies reveal a synergistic effect of porphyrin functionalisation on the carbon dots, which improves electron injection and transport toward the emissive layer. At an optimum concentration of 1 mg mL −1 , the TCPP-NCDots ETL yields a 21.6% enhancement in external quantum efficiency compared with the reference device without an ETL, while simultaneously suppressing efficiency roll-off. The optimised devices also maintain stable operation under ambient conditions, highlighting TCPP-NCDots as a promising, sustainable ETL platform for next-generation fluorescent OLEDs.

A recyclable dendrimeric Ni nanocatalyst anchored on magnetic nanoparticles for the green reduction of nitroarene pollutants and one-pot synthesis of imines

Fast-powerformer achieves accurate and memory-efficient mid-term wind power forecasting

Body condition among Svalbard Polar bears Ursus maritimus during a period of rapid loss of sea ice

Abstract Polar bears are only found in Arctic areas with sufficient access to sea ice and seals on which they prey. Studies have highlighted negative effects on condition and demographics in areas where sea ice cover is declining due to warmer climate, but condition of the Barents Sea polar bear population have not been examined yet. Loss of sea ice rate has been considerably higher here than in other areas with polar bears. We investigated variation in body condition index (BCI) among 770 adult bears, 1188 captures, in March-May 1995–2019, in Svalbard, Norway (western part of the Barents Sea). We assessed how intrinsic (female reproductive state, age) and both males and females, BCI declined until 2000, but increased afterwards, during a period with rapid loss of sea ice. In models including sea ice metrics and climate (Arctic Oscillation), there was no support for the predicted negative effect of warmer weather and habitat loss. This indicates a complex relationship between habitat, ecosystem structure, energy intake, and energy expenditure. Increases in some prey species, including harbour seals, reindeer, and walrus, may partly offset reduced access to seals. Our findings underline the importance not to extrapolate findings across populations.