Browse Articles

The long non-coding RNA MALAT1 encodes a micropeptide that promotes influenza A virus replication by suppressing innate immune responses

Nonopioid analgesic alleviates neuropathic pain

FBXW7 E3 ligase prevents centriole overduplication by degrading the Plk4 phosphorylated STIL-SAS6 cartwheel assembly

Histone methyltransferase inhibition hampers prostate cancer

AGEs promote the metastasis of colorectal cancer cells via centrosome amplification by KLF5–CEP57L1 axis

Methyl-CpG-binding protein 2 reads histone methylation via an aromatic cage to regulate gene expression and chromatin association

Repurposing nuclear receptors for ligand-responsive liquid condensate formation and gene regulation

Bioinspired charge reservoir enables efficient CO2 photoreduction with H2O via tungsten valence oscillation

Saturation of space weathering in shaping lunar regolith particle morphology

Aeromonas in South Asia: genomic insights into an environmental pathogen and reservoir of antimicrobial resistance

Abstract Aeromonads are an ecologically versatile group of bacteria that cause infections in aquatic animals and are recognised as emerging human pathogens. Despite this, our understanding of Aeromonas diversity, especially the relationship between clinical and environmental strains, remains limited. Here, we present a genomic analysis of the Aeromonas genus, comprising 1853 genomes, and a detailed comparison of clinical and environmental strains from South Asia, including 996 newly sequenced genomes from Bangladesh and India. Phylogenetic analyses revealed that Aeromonas is a highly diverse genus, with no distinct clade separating clinical and environmental isolates. We identified 28 Aeromonas species and 905 novel sequence types, comprising 72.5% of the genomes. Notably, we show a high incidence of antimicrobial resistance (AMR) genes across all isolates, including against front and last-line antibiotics. Finally, we highlight frequent misidentification of Aeromonas as Vibrio cholerae , which is relevant to cholera-endemic regions where both genera co-exist and are associated with diarrhoeal disease. Our study underscores Aeromonas as an important environmental AMR reservoir and emerging multi-species pathogen capable of spilling over into human populations.

Developments and challenges in hit progression within fragment-based drug discovery

Tunable chiral and nematic states in the triple-Q antiferromagnet Co1/3TaS2

Abstract Complex spin configurations in magnetic materials, ranging from collinear single- Q to non-coplanar multi- Q states, exhibit rich symmetry and chiral properties. However, their detailed characterization is often hindered by the limited spatial resolution of neutron diffraction techniques. Here we employ magnetic circular dichroism and magnetic linear dichroism to investigate the triangular lattice antiferromagnet Co 1/3 TaS 2 , revealing three-state ( Z 3 ) nematicity and also spin chirality across its multi- Q magnetic phases. At intermediate temperatures, the presence of linear dichroism identifies nematicity arising from a single- Q stripe phase, while at high magnetic fields and low temperatures, a phase characterized solely by circular dichroism emerges, signifying a purely chiral non-coplanar triple- Q state. Notably, at low temperatures and small fields, we discover a unique phase where both chirality and nematicity coexist. A theoretical analysis based on a continuous multi- Q manifold captures the emergence of these distinct magnetic phases, as a result of the interplay between four-spin interactions and weak magnetic anisotropy. Additionally, both circular and linear dichroism microscopy spatially resolves the chiral and nematic domains. Our findings establish Co 1/3 TaS 2 as a rare platform hosting diverse multi- Q states with distinct combinations of spin chirality and nematicity while demonstrating the effectiveness of polarized optical techniques in characterizing complex magnetic textures.

Experimental realization of dice-lattice flat band at the Fermi level in layered electride YCl

Microbiota-induced EI24 improves homeostasis but impedes function of alveolar macrophages via metabolic regulation

Vertical chiral emission from an intrinsically achiral metasurface enabled with anisotropic continuum

Strain-invariant omnidirectional stretchable MXetronics

Insights into the structure and modulation of human TWIK-2

Modulating thermo-diffusion/galvanic coupling via ion speciation engineering enables high-performance ionic thermoelectric cells

Recurrent connections facilitate occluded object recognition by explaining-away

Abstract Despite the ubiquity of recurrent connections in the brain, their role in visual processing is less understood than that of feedforward connections. Occluded object recognition, an important cognitive capacity, is thought to rely on recurrent processing of visual information, but it remains unclear whether and how recurrent processing improves recognition of occluded objects. Using convolutional models of the visual system, we demonstrate how a distinct form of computation arises in recurrent–but not feedforward–networks that leverages information about the occluder to “explain-away” the occlusion—i.e., recognition of the occluder provides an account for missing or altered features, potentially rescuing recognition of occluded objects. This occurs without any constraint placed on the computation and is observed both across a systematic architecture sweep of convolutional models and in a model explicitly constructed to approximate the primate visual system. In line with these results, we find evidence consistent with explaining-away in a human psychophysics experiment. Finally, we developed an experimentally inspired recurrent model that recovers fine-grained features of occluded stimuli by explaining-away. Recurrent connections’ capability to explain-away may extend to more general cases where undoing context-dependent changes in representations benefits perception.

Plasma proteome mediates the associations between air pollution exposure and disease risk