Browse Articles

AI and human expertise in cancer care — striving for synergy

Nature Reviews Clinical Oncology Milit S. Patel, Edward Christopher Dee, Nancy Y. Lee Feb 01, 2026 DOI: 10.1038/s41571-025-01108-9

Unique bifunctional α-sialidase/β-N-acetylgalactosaminidase from Bifidobacterium bifidum acting on the Sda antigen

Journal of Biological Chemistry Toshihiko Katoh, Rina Suzuki, Shogo Kataoka et al. Feb 01, 2026 DOI: 10.1016/j.jbc.2025.111121

Could a COVID-19 vaccine improve the effectiveness of cancer immunotherapy?

Nature Reviews Clinical Oncology Sacha Gnjatic Feb 01, 2026 DOI: 10.1038/s41571-025-01105-y

Structural and functional consequences of aspartate/asparagine-β-hydroxylase variants causing Traboulsi syndrome

Journal of Biological Chemistry Cynthia X. Hou, Amelia Brasnett, Patrick Rabe et al. Feb 01, 2026 DOI: 10.1016/j.jbc.2025.111008

T-DXd plus pertuzumab effective as first-line therapy

Nature Reviews Clinical Oncology Peter Sidaway Feb 01, 2026 DOI: 10.1038/s41571-025-01106-x

Structural and functional insights into calmodulin-mediated lipid binding and proteolytic cleavage of the M-PMV matrix protein

Journal of Biological Chemistry Karolina Buresova, Tereza Nesporova, Jan Prchal et al. Feb 01, 2026 DOI: 10.1016/j.jbc.2025.111102

Sentinel lymph node biopsy improves surgical management of cervical cancer

Nature Reviews Clinical Oncology Diana Romero Feb 01, 2026 DOI: 10.1038/s41571-025-01107-w

Regulating the orientation of homobivalent small binders through 3D domain-swapping design

Journal of Biological Chemistry Shota Shiga, Hideki Watanabe, Koki Makabe et al. Feb 01, 2026 DOI: 10.1016/j.jbc.2025.111053

ANP32A-mediated histone 3 K27 acetylation is essential for sotorasib activity in KRAS-mutant non–small cell lung cancer

Journal of Biological Chemistry Kailing Pan, Mingjing Dang, Bo Xu et al. Feb 01, 2026 DOI: 10.1016/j.jbc.2025.111110

Hyaluronic acid regulates cellular UDP-GlcNAc levels through CD44 to affect glycosylation and cell biological functions

Journal of Biological Chemistry Yue Wang, Tomoya Isaji, Tiangui Wu et al. Feb 01, 2026 DOI: 10.1016/j.jbc.2025.111111

T-DXd shows promise in neoadjuvant therapy for HER2+ breast cancer

Nature Reviews Clinical Oncology David Killock Feb 01, 2026 DOI: 10.1038/s41571-025-01103-0

Allosteric zinc inhibition and interdomain regulation govern the catalytic mechanism of the E3-independent ubiquitin-conjugating enzyme hUBE2O

Journal of Biological Chemistry Dan Xiang, Xiaoxiao Tang, Ruona Shi et al. Feb 01, 2026 DOI: 10.1016/j.jbc.2025.111122

Enhanced lysosomal activity prevents infection with PrPSc and the seeding activity of α-synuclein & tau prions

Journal of Biological Chemistry Robert C.C. Mercer, Nhat T.T. Le, Nadia A. Mirza-Romero et al. Feb 01, 2026 DOI: 10.1016/j.jbc.2025.111050

Nanobodies against Clostridioides difficile CDTb provide a toolkit for potent toxin neutralization and highly sensitive quantitation

Journal of Biological Chemistry Kateryna Nabukhotna, Heather K. Kroh, David M. Anderson et al. Feb 01, 2026 DOI: 10.1016/j.jbc.2025.111082

Neurofascin stabilization by contactin-associated protein-like 2 and CTCF alleviates mitochondrial dysfunction in Schwann cells during facial nerve injury

Journal of Biological Chemistry Jin Zhu, Xin Ouyang, Lifu Yu et al. Feb 01, 2026 DOI: 10.1016/j.jbc.2025.111090

A reversible feedback mechanism regulating mitochondrial heme synthesis

Journal of Biological Chemistry Iva Chitrakar, Alexis B. Roberson, Pedro H. Ayres-Galhardo et al. Feb 01, 2026 DOI: 10.1016/j.jbc.2025.111089

Ser500 phosphorylation acts as a conformational switch to prime eEF-2K for activation

Journal of Biological Chemistry Amanda L. Bohanon, Luke S. Browning, Andrea Piserchio et al. Feb 01, 2026 DOI: 10.1016/j.jbc.2025.111087

A neural glycan HNK-1 is transferred to recipient cells via small extracellular vesicles

Journal of Biological Chemistry Yuko Tokoro, Yasuhiko Kizuka Feb 01, 2026 DOI: 10.1016/j.jbc.2026.111144

Threonyl-tRNA synthetase activates STAT3 by a nontranslational mechanism

Journal of Biological Chemistry Pallob Barai, Reean Abdullah, Shruti V. Bendre et al. Feb 01, 2026 DOI: 10.1016/j.jbc.2025.111032

Small molecule intervention of actin-binding protein profilin1 reduces tumor angiogenesis in renal cell carcinoma

Journal of Biological Chemistry David Gau, Pooja Chawla, Kexin Xu et al. Feb 01, 2026 DOI: 10.1016/j.jbc.2025.111033