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Happy and angry human pictures differentially affect dogs’ postural stability
Abstract In humans, visual stimuli are known to elicit biomechanical balance responses, thereby influencing postural stability. These responses offer valuable insights into the relationship between visual perception and physical balance. This is the first study to examine the effect of human pictures on postural stability in dogs. Seventeen healthy pet dogs were evaluated standing on a pressure plate under three conditions: viewing happy human pictures, angry human pictures, and no-picture. Five conventional Center of Pressure (COP) parameters were analyzed; mediolateral displacement, craniocaudal displacement, support surface, average speed (AS) and statokinesiogram length. Although no significant differences in balance were found across the three conditions overall, a cluster analysis of relative COP changes (ΔCOP_%, increase/decrease relative to the no-picture condition) revealed two distinct reaction patterns within both picture conditions. For happy pictures, 35% of dogs exhibited increases across all ΔCOP_% parameters (cluster H2), while 65% showed decreases (cluster H1). Angry pictures led to increases across all ΔCOP_% parameters in 47% of dogs (cluster A2), while 53% showed decreases (cluster A1). Comparisons within clusters H1/H2 and A1/A2 revealed significant differences in ΔCOP_% parameters (ANOVA, all ΔCOP_% parameters, p < 0.05, except AS within happy condition). No significant differences in ΔCOP_% parameters were found between clusters H1/A1 (decrease in all ΔCOP values) and between clusters H2/A2 (increase in all ΔCOP values). This exploratory study is the first to suggest that emotional human pictures evoke varied postural responses in dogs, influenced by the type of stimulus (happy or angry) and individual differences in emotional reactivity and sensory processing. Both emotions (happy, angry) resulted in increases in all ΔCOP_% parameters, interpreted as a destabilizing effect on balance, and decreases in ΔCOP_% parameters, interpreted as stabilizing effect on balance.
A wavelet-based frequency-domain approach for accurate multi-crop disease detection
Panoramic image restoration and visual quality enhancement methods for digital art creation
Effect of simultaneous application of low-level diode laser and leukocyte platelet-rich fibrin on gingival tissue healing: an in vitro investigation
Risk sources quantitative identification of heavy metals in coal mining hinterland river sediments, Northern China
Obinutuzumab induces lysosomal destabilization via sphingomyelin-dependent inhibition of TRPML2
Functional brain mapping of body size estimation using a 3D avatar
Abstract Body size estimation—the ability to judge the size and shape of one’s own body—is a key perceptual component of body image. However, its neural basis, and the basis for inter-individual differences in accuracy, remain poorly understood, partly due to limitations in existing assessment tools. We used an adapted, fMRI-compatible version of Somatomap 3D, an interactive task in which participants manipulate a rotatable 3D avatar by adjusting the size and shape of 26 individual body parts to match their perceived body. Twenty-eight healthy male and female adults completed the task during fMRI. Brain activity in a priori regions of interest from previous studies of body processing was modeled using a general linear model incorporating event-specific parameters and parametric modulators related to task performance. Inter-individual differences in body size estimation accuracy were calculated using multidimensional scaling of body part estimation errors, and scores were correlated with BOLD signal eigenvariates from regions of interest. Task engagement was associated with significant activation in hypothesized body-selective and multisensory regions, including bilateral extrastriate body area, right fusiform body area, right superior parietal lobule, and bilateral premotor cortex. Multidimensional scaling identified a primary subdimension reflecting distortions in body part girths, which was significantly associated with neural responses in bilateral superior parietal lobule. No other brain regions showed significant associations with inter-individual differences in estimation accuracy. These results suggest that body size estimation engages a distributed network of visual, motor, and parietal regions. Among these, only the superior parietal lobule showed a significant association with inter-individual variation in body size estimation accuracy for body part girths, supporting its role as a candidate neural substrate for altered body representation in psychiatric conditions such as eating disorders and body dysmorphic disorder.
A multi-scale end-to-end visible and infrared image enhancement fusion method
Research on infrastructure network protection strategy based on bayesian stackelberg game under asymmetric conditions
Expression patterns of bone morphogenetic protein 7 (BMP7) and its prognostic roles in neuroblastoma: An integrated bioinformatics analysis
Background Bone morphogenetic proteins (BMPs) are associated with the prognosis of various types of adult cancers. However, the expressions and prognosis of BMPs in pediatric neuroblastoma remain unclear. Methods Six publicly available neuroblastoma cohorts were downloaded for bioinformatics analysis. The prognosis of BMPs in neuroblastoma was determined using cox regression analysis and Kaplan-Meier survival analysis. Results Our study revealed that, compared to other BMP family members, BMP1, BMP7 and BMP8B were highly expressed in neuroblastoma. However, only BMP7 was associated with the prognosis of neuroblastoma in all six neuroblastoma cohorts. Higher BMP7 expression was associated with the shorted event free survival and overall survival of neuroblastoma. The prognosis of BMP7 in neuroblastoma was independent of age and MYCN amplification. The expressions of BMP7 were higher in neuroblastoma patients with MYCN amplification or age ≥ 18months or in stage 4 neuroblastoma. Moreover, higher BMP7 was associated with the shorted event free survival and overall survival of MYCN amplified or stage 4 neuroblastoma. At last, we found that breast cancer metastasis suppressor 1 (BRMS1) was correlated with BMP7 expression. However, in contrast with the suppressor role of BRMS1 in adult cancers, BRMS1 was significantly associated with the unfavorable clinical outcomes of neuroblastoma. Overall, our analysis the demonstrated correlations between BMPs and clinical features of neuroblastoma and provided unique therapeutic targets for neuroblastoma treatments. Conclusions BMP7 was a prognostic maker of neuroblastoma.
Activated T cells induce apoptosis in A549 lung adenocarcinoma cells via TRPV4-mediated calcium influx
Effects of fermented Rosa roxburghii Tratt pomace on growth performance, lipid metabolism, antioxidant activity, and amino and fatty acid profile in goats
Rosa roxburghii Tratt pomace, is a juice extraction rich in polyphenols with strong antioxidant activity. The objective of this study was to evaluate the effect of fermented Rosa roxburghii Tratt pomace (FRRT) on growth performance, plasma biochemistry and antioxidant status, and longissimus dorsi muscle amino- and fatty-acid profiles in meat goats. Twenty-four goats with similar body weights (30.7 ± 4.71 kg) were allotted in a completely randomized design to either basal diet (CON) or the same diet containing 7% (LF) or14% (HF) of FRRT on a total mixed ration (TMR) dry matter (DM) basis for 60 d following 14 d adaptation. FRRT did not alter dry matter intake or average daily weight gain, but reduced ( P < 0.05) the feed conversion ratio (FCR) compared to CON. Plasma creatinine and total cholesterol increased ( P < 0.05) with FRRT, while low-density lipoprotein cholesterol (LDL-C) was numerically higher in the HF group (overall P = 0.069). FRRT increased ( P < 0.05) the plasma total antioxidant capacity and catalase; malondialdehyde tended to be lower ( P = 0.067) HF group than CON. In muscle, the 14% FRRT diet increased essential, non-essential, flavor and total amino acids ( P < 0.05), with higher concentrations of several individual amino acids (e.g., threonine, serine, glycine, tyrosine, lysine, arginine). Among fatty acids, C15:0 decreased in 7% FRRT ( P < 0.05) and arachidonic acid (C20:4n-6) increased ( P < 0.05), whereas sums of SFA, MUFA and PUFA did not differ. In conclusion, 7–14% FRRT (DM basis) improved feed efficiency and antioxidant status and favorably modified selected muscle amino- and fatty-acid traits, but elevated circulating cholesterol; the lipid responses warrant further study.
Correction: GRB2 promotes brain metastasis in HER2-positive breast cancer by regulating the Ras/MAPK pathway
Effects of digital game-based learning as a tool for laparoscopy training in surgical nursing
Background The present study aimed to (1) develop a digital game focusing on the roles of surgical nurses (scrub and circulator nurses) in laparoscopic surgeries, (2) conduct a randomized controlled trial (RCT) comparing this digital game-based learning (GBL) approach with a conventional teaching method, and (3) assess students’ reasoning and user satisfaction. Method This randomized controlled trial (RCT) was conducted at Shahid Sadoughi University of Medical Sciences. The study comprised three phases: development of the digital game titled ‘Co-Surgeon,’ implementation of the educational interventions, and evaluation of outcomes. The digital game aimed to enhance students’ understanding of laparoscopic surgeries and the specific roles of surgical nurses (circulator and scrub), focusing on tasks such as task recognition, laparoscopic instrument identification and utilization, procedural steps, and the development of clinical reasoning for selecting appropriate tools during common laparoscopic procedures. Fifty-seven surgical nursing students were randomly assigned to either an intervention group, which utilized digital game-based learning, or a control group, which received conventional lecture-based education. The digital GBL application included 40 distinct laparoscopic tools and equipment organized into 8 categories, 8 puzzles related to surgical nurse roles in abdominal laparoscopic surgeries, 15 Mayo stand setups, and 60 instrument identification puzzles. User satisfaction was measured via the Questionnaire for User Interface Satisfaction (QUIS), and students’ reasoning was assessed through the Key Feature (KF) examination. Data were summarized using descriptive statistics (mean, standard deviation, and percentage). Pearson correlation coefficient, independent t-test, and paired t-test were used for data analysis. Results The mean (SD) scores of students’ reasoning in the intervention group (19.51 ± 3.36) were significantly higher than those in the control group (13.92 ± 4.15). (p < 0.001), with a large educational effect size reported (Partial eta squared = 0.35). Student perception scores indicated a good level of satisfaction (184.85 ± 6.79). Conclusion The diverse and complex responsibilities of surgical nurses make it essential to enhance the learning outcomes for surgical nursing students. Implementing digital game-based learning can positively impact these outcomes. Therefore, it is recommended to incorporate digital games as a supplement in clinical education and workplace-based training.
Bronchial artery infusion of PD-1 inhibitors plus chemotherapy improves progression-free survival in advanced NSCLC: a prospective cohort study
Correction: Delayed hepatic response and impaired cytokine dynamics in aged mice following burn injury: Implications for elderly patient care
LC-MS/MS characterization, biological activity, and carbonic anhydrase inhibitory potential of five medicinal plant extracts from Romania and Türkiye
Spatial analysis of mortality due to congenital syphilis in Brazil from 2008 to 2022
The objective of this study is to analyze spatial distribution of mortality due to congenital syphilis in Brazil from 2008 to 2022. This is an ecological study that considered congenital syphilis deaths reported in all Brazilian municipalities, from 2008 to 2022, available in the Brazilian government’s information systems. We built a thematic map to describe the distribution of congenital syphilis mortality in the country and, subsequently, applied the Local Index Spatial Analysis to identify possible spatial clusters. Finally, we used the Ordinary Least Squares and Geographically Weighted Regression models to identify mortality predictors in the territory. The mortality rate from congenital syphilis was 0.64 deaths per 1,000 live births. The distribution of deaths occurred heterogeneously, with the highest rates in the states of Pará, Acre, Rondônia, Rio de Janeiro and part of Amazonas. We identified statistically significant spatial clusters across the country, with the formation of clusters with a high-high pattern in Pará, Rio de Janeiro, and Mato Grosso (p < 0.05). We observed that the Gini index (p = 0.008; 95% Confidence Interval: 0.02–0.11), the number of nurses in primary care (p = 0.027; 95% Confidence Interval: 0.0005–0.00003) and the proportion of non-treponemal tests by pregnant women (p = 0.016; 95% Confidence Interval: 0.005–0.001) are variables that influence the occurrence of deaths. Congenital syphilis deaths in Brazil occur heterogeneously, with different rates between regions, which are geographically influenced by social and healthcare characteristics of the location.