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Microplastic contamination in tadpoles (Anura) in the Brazilian Amazon
Phytochemical Characterisation, antioxidant, anti-inflammatory, antibacterial, antibiofilm, anticancer properties and therapeutic potentials of Eucalyptus globulus essential oil
Hair and wool of ruminants and canines as environmental vectors of Bacillus anthracis and potential human exposure in anthrax-endemic regions
E-selectin-targeted microbubbles combined with ultrasound improves renoprotective effects of methylprednisolone on cisplatin-induced acute kidney injury in rats
Predicting intracranial hypertension as a secondary insult using the pathological peptidome of brain injured patients
Dynamical analysis and soliton solutions to (3+1)-dimensional extended quantum nonlinear Zakharov–Kuznetsov equation
Associations between smartphone addiction, anxiety, depression, and academic performance among university students
Comparative analysis towards the identification of genome wide characteristics of a beneficial fungal endophyte
Target trial emulation of early acetaminophen use and mortality in critically ill stroke patients
Frost damage segmentation in grapevine organs using YOLOv11s with ASPP and dynamic confidence thresholding
Study on the evolution law of overlying strata movement inducing surface subsidence under different mining sequences of multiple coal seams: a case study
Failure mechanisms and stability control of roadways in thermally damaged rock under asymmetric stress: a case study
Abstract Stability maintenance of deep roadways in thermally damaged rock masses presents complex challenges under asymmetric stress conditions. This study investigates the failure mechanisms and proposes a control strategy using an integrated methodology of laboratory testing, theoretical analysis, and field validation. Triaxial compression tests with Acoustic Emission monitoring indicated that the mechanical degradation of thermally damaged rock is primarily influenced by the propagation of pre-existing microcracks. An analytical model based on the complex variable method quantified the stress field around a rectangular opening, incorporating the effect of principal stress rotation. The analysis revealed a coupled failure mechanism where stress asymmetry governs the inclined X-shaped plastic failure geometry while degraded rock properties determine the extent of the plastic zone. To address this mechanism, a Reinforcement-Anchorage-Confinement (RAC) collaborative support system was developed. Numerical simulations and a field application demonstrated that the RAC system controls fracture propagation and maintains roadway deformation within acceptable operational limits. This research provides a mechanistic framework for roadway stability control in similar geomechanical environments.
Photodynamic larvicidal activity of magnesium chlorophyllin and magnesium chlorophyllin zinc oxide nanocomposite against Spodoptera frugiperda with non-target safety assessment
Abstract Chemical pesticides have been used as a reliable method of controlling pests on crops. However, their applications have led to the development of resistance, environmental problems, and risks to human health. Therefore, new chemicals in nanoform such as chlorophyll derivatives could be a good choice for pest control through the induction of reactive oxygen species, liberating singlet oxygen when they are excited by photo exposure. The present work evaluated the toxicity of magnesium chlorophyllin (Mg-Chl) and magnesium chlorophyllin zinc oxide (Mg-Chl–ZnO NC) nanocomposite on Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae) . Additionally, the biochemical changes of detoxifying enzymes, such as carboxylesterases (CXEs) and glutathione- S -transferases (GSTs), were investigated. In silico, molecular docking analysis was also performed to assess the binding affinities of the tested compounds to CXE22 and SfGSTe9 . Thus, the evaluation of potential photosensitizers against the second instar larvae of Chrysoperla carnea Stephens, as non-target insect and active predator of aphids, was conducted. The results showed that both Mg-Chl and Mg-Chl–ZnO NC have a high potency against S. frugiperda with LC 50 = 0.59 and 0.49 mg L −1 , respectively, after 12-h dark incubation and 5-h light exposure, while after 24 h, LC 50 values after dark incubation were 0.51 and 0.31 mg L −1 , respectively. Both tested compounds exhibited a strong binding affinity to CXE22 and SfGSTe9 , leading to significant alterations in CXEs activity and GSTs activity in correspondence with the oxidative stress and contributing to larval mortality. In parallel, both compounds exhibited very low toxicity on C. carnea . Overall, these findings support that Mg-Chl and Mg-Chl–ZnO NC could be used as alternative approaches to synthetic pesticides for the management of S. frugiperda .
Resolving fluorescently labeled species using highly multiplexed spectral FLIM
Genetic diversity, population structure and haplotype analysis of Babesia gibsoni based on the thrombospondin-related adhesive protein (TRAP) gene
Microstructural characterization and creep response of Gleeble-simulated heat-affected zone of electron beam welded Grade 91 steel
Acteoside attenuates myocardial ischemia reperfusion injury by inhibiting the NLRP3 inflammasome activity via the PI3K/Akt signaling pathway
Short-term dietary deoxynivalenol exposure negatively affects performance, intestinal and reproductive functions in laying hens
Abstract The detrimental effects of deoxynivalenol (DON) on broiler chickens are well documented; however, studies on laying hens fed diets naturally contaminated with this mycotoxin remain limited. To evaluate the impact of short-term DON exposure, 600 56-week-old Dekalb White laying hens were fed either a marginally contaminated control diet (CON) or a diet containing 2.45 mg/kg DON for 16 weeks. Production performance was impaired by DON as early as 8 weeks of exposure. Although no changes were observed in the physical characteristics of the eggshells, mRNA expression analyses revealed disruptions in calcium and phosphorus metabolism. Despite similar egg production between treatments, DON exposure led to degeneration of primordial, primary, and large white follicles. Metabolomic analysis of the excreta indicated altered lipid metabolism, suggestive of intestinal inflammation, along with increased hydrogen sulphide (H 2 S) levels. In conclusion, short-term exposure to DON negatively affects intestinal function, reproductive health, and feed efficiency in laying hens.