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Spatio-temporal analysis of violence notifications among the transgender population in Brazil (2015–2023)
Meningococcal B Vaccine to Prevent <i>Neisseria gonorrhoeae</i> Infection
Mechanical performance of basalt fiber reinforced cementitious mortars incorporating calcined red mud
Koebner Phenomenon from Wet Cupping
Trends and characteristics of major salivary gland carcinoma incidence in the United States, 2000–2022
Mitochondrial l-2-hydroxyglutarate is a physiological signalling metabolite
Fluorination of White Phosphorus with Fluoride Salts and Quinone Oxidants
Case 21-2026: A 28-Year-Old Man with Headache and Vision Loss in the Right Eye
Discovery of novel 2H-pyrrol-2-one herbicides through multicomponent synthesis and photosystem II evaluation
Potential-Gated Transient Zn Single Adatoms on the Inverse Zn <sub>1</sub> O <i> <sub>x</sub> </i> /Cu Catalyst Steer Efficient Electroreduction of CO <sub>2</sub>
More on Digital Twin–Guided Ablation for Ventricular Tachycardia
Prevalence, antimicrobial resistance, and virulence factors of Enterococcus spp. infecting broiler chickens in Egypt
Abstract Enterococcus spp. are potential pathogens in broiler chickens, causing economic losses in addition to their extensive capacity to acquire and disseminate antimicrobial resistance genes among various bacterial species. This study was conducted to investigate the occurrence of enterococcal infections among broiler chickens in Qena and Sohag Governorates, Egypt, to determine antimicrobial resistance and virulence factors of enterococci isolates, and to screen them for the presence of class 1 and 2 integrons by PCR. Therefore, 120 samples were collected from the diseased broiler chickens aged 1 to 35 days from 30 different commercial farms. The birds were clinically and bacteriologically examined for enterococci, and then antimicrobial susceptibility and virulence factors of enterococci isolates were determined, in addition to their investigation for the presence of some genes by PCR. Enterococci were isolated from 22.5% of the examined birds and were identified as E. faecalis , E. faecium , and E. gallinarum with prevalence of 11.7%, 7.5%, and 3.3%, respectively. The infected birds showed lameness, body weight loss, arthritis, omphalitis, and yolk sac infection in chicks, as well as septicemia and endocarditis in some birds. All enterococci isolates were gelatinase producers, while 18.5% and 81.5% of them were β-haemolytic and biofilm formers with varying grades, respectively. Respective to isolatesʼ antimicrobial susceptibility, 63% of them were multidrug-resistant enterococci with higher occurrence (70.6%) among the class 1 integrons-positive isolates. PCR revealed that 100%, 81.5%, 74.1%, 74.1%, 48.1%, 37.0%, 7.4%, and 3.7% of the isolates carried gelE , aac(6’)/aph(2’’) , ermB , tetM , int1 , cylA , vanA , and int2 genes, respectively. This study demonstrated a high prevalence of pathogenic MDR-enterococci among broiler chickens, posing a hazard for poultry health and a potential public health concern. Furthermore, it reported for the first time, to the best of our knowledge, the presence of a high prevalence of class 1 integrons among enterococci in Egypt. Therefore, strict biosecurity protocols and prudent antimicrobial stewardship strategies should be implemented urgently.
Reprogramming Glutathione-Binding Proteins into Artificial Photoenzymes by Engineered Glutathione-Type Cofactors
A hybrid explainable deep learning framework for blood cancer classification using CNN-based feature embeddings and random forest decision models
Heat-triggered phospholipid flipping stabilizes plasma membrane fluidity
Enzyme-Inspired Design of Well-Defined Dual-Metal-Site Pairs Confined within Metal–Organic Frameworks for Tailoring Photocatalytic Microenvironments
Multi-modal fusion of acoustic and microwave signals for early detection of Red Palm Weevil infestation
Genetic analysis of circulating metabolic traits in 619,372 individuals
Abstract Interpreting the association of genetic variants with complex traits can be improved by gaining a greater understanding of the molecular consequences of these variants. Although genome-wide association studies (GWAS) for complex diseases routinely profile over one million individuals 1–5 , studies of molecular traits have lagged behind. Here we performed a GWAS meta-analysis for 249 circulating metabolic traits in the Estonian Biobank and the UK Biobank in up to 619,372 individuals. We identified 88,127 common and low-frequency locus–trait associations from 8,398 loci that converged on shared genes and pathways. Using statistical fine mapping, systematic phenome-wide colocalization and cis -Mendelian randomization, we explored putative causal links between metabolic traits and disease outcomes. We predict that although plasma branched-chain amino acids (BCAAs) have been associated with type 2 diabetes in observational studies 6,7 , lowering BCAA levels by targeting the BCAA catabolism pathway is unlikely to reduce type 2 diabetes risk. Leveraging our large sample size and high-quality genotype imputation, we found that 19.4% of the confidently fine-mapped variants had minor allele frequencies between 0.1 and 1%, and these variants were twofold enriched for predicted missense and splice-altering variants. Our results highlight the value of integrating low-frequency variants into genetic association studies.