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H. pylori-induced hsa_circ_0085465 promotes gastric cancer cell proliferation, migration, and invasion by sponging miR-33b-3p
Correction to: 2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines
EEG-based biomarker for the identification of mild cognitive impairment via coherency analysis and iterative dynamic time warping
The most efficient origami torus
A paper torus, also called an origami torus, is a torus in three-dimensional space that is made from finitely many triangles which fit together in such a way that the sum of the angles around each vertex is 2 π . This article announces the result that there does not exist an origami torus with 7 vertices and there does exist an origami torus with 8 vertices. These results settle the question about the most efficient way, in terms of the number of vertices, to construct an origami torus.
Physical Activity in Pediatric Cardiomyopathies: Moving for Health: A Scientific Statement From the American Heart Association
Physical activity (PA) is essential for the cardiovascular, emotional, and social health of all children and adolescents. However, for pediatric patients with cardiomyopathy, decades of risk-averse clinical guidance have resulted in widespread PA restriction due to fears of sudden cardiac death and disease progression. This has contributed to sedentary behavior, poor cardiorespiratory fitness, and increased risk of secondary cardiometabolic conditions in this population. However, emerging data challenge this restrictive paradigm, showing that the risk of sudden cardiac death may not be higher in some patients with cardiomyopathy who exercise than in those who are less active, and that participation in PA may also have a positive effect on reverse remodeling. This American Heart Association scientific statement provides an evidence-based framework for the promotion of PA in pediatric patients with hypertrophic cardiomyopathy, dilated cardiomyopathy, restrictive cardiomyopathy, or arrhythmogenic cardiomyopathy, as well as those with implantable cardioverter defibrillators; outlines the physical, social, and emotional benefits of PA for these children and adolescents; and provides updated risk stratification strategies, including the use of advanced imaging, exercise testing, and genotype-specific data. This scientific statement underscores the importance of shared decision-making tailored to developmental maturity and family goals and emphasizes the need for longitudinal surveillance as clinical phenotypes evolve. With individualized assessment and informed shared decision-making, most children and adolescents with cardiomyopathy can safely engage in PA, with important implications for long-term cardiometabolic and psychologic health.
Herbosomal nanocarriers using natural-origin surfactants: a quercetin-based strategy for Alzheimer’s disease and oxidative-stress–driven neurodegeneration
Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by oxidative stress, neuroinflammation, and cholinergic dysfunction. Quercetin (QUE) is a multifunctional flavonoid with potent antioxidant and anti-inflammatory effects and proven neuroprotective, anticancer, antimicrobial, and hepatoprotective potential. However, its therapeutic translation, particularly in the management of Alzheimer’s disease, is severely limited by low aqueous solubility, low bioavailability, and rapid metabolism. The current study aims to develop QUE-loaded herbosomes as an advanced phytophospholipid delivery system for AD treatment, with a focus on replacing the synthetic surfactant Tween 80 with natural-origin betaine surfactants to overcome the drawbacks of poor biocompatibility and chronic toxicity associated with conventional surfactants. QUE herbosomes were developed using the thin-film hydration method and evaluated for physicochemical characteristics, stability, and in vitro release behavior. Formulation variables were optimized to obtain herbosomal systems with favorable nanoscale properties and sustained drug release. DSC and FTIR analyses confirmed successful incorporation of quercetin within the vesicular structure. Compared with QUE suspension, the optimized QUE herbosomal formulations (F5 &F6) showed significantly higher effect in aluminum chloride-induced AD as evidenced by Behavioral testing, biochemical, and Histopathological analyses. These findings suggest that the developed QUE herbosomes with natural-origin surfactants offer a safe and biocompatible alternative to synthetic surfactant herbosomes, improving therapeutic outcomes in AD and holding promise for other oxidative stress-related neurodegenerative conditions.
Ultra-Processed Foods Harm Male Metabolic and Reproductive Health
Detection of maxillary sinusitis of endodontic origin in cone-beam CT images using deep learning algorithms
Abstract Cone-Beam Computed Tomography (CBCT) scans were retrospectively collected and examined to acquire a balanced dataset representative of Normal Maxillary Sinus (NMS), Maxillary Sinusitis of Endodontic origin (MSEO), and Maxillary Sinusitis of Non-Endodontic origin (MS-NEO) according to established criteria. Data were manually labeled, pre-processed and split into training, validation, and testing groups. A custom model workflow started by anatomic classification of input images as being coronal, sagittal, or axial, followed by segmentation of roots, lining, and sinus regions, followed by extraction of radiographic sinus features for final classification of NMS, MSEO, or MS-NEO. Model performance on testing and external datasets was performed evaluating Accuracy, Precision, Recall, F1, and DICE scores. Results showed that the anatomic classifier achieved overall Accuracy, Precision, Recall, and F1 scores of 0.99 and 0.98 on the testing and external datasets. The overall DICE scores for sagittal, coronal, and axial segmenters were 0.8, 1, and 0.9 on the testing, and 0.8, 0.9, and 0.9 on the external dataset. The features extractor achieved overall Accuracy and F1 scores of 0.9–1 for sagittal, coronal, and axial classifiers for testing and external datasets, while the Multi-View classifier exhibited excellent metrics for both datasets with potential to improve clinical diagnosis of MSEO.
Impact of Angina on Outcome After Percutaneous Coronary Intervention in Patients Undergoing Transcatheter Aortic Valve Implantation: Insights From the NOTION-3 Trial
Household air pollution and under-five mortality in Kyrgyzstan: a survival analysis using multiple indicator cluster survey 2023 data
Correction to: Abstract 4368321: A Rare Unusual Location Of A Papillary Fibroelastoma Originating From The Coumadin Ridge
Novel rewiring mechanism for restoration of the fragmented social networks after attacks
Anticoagulation Services as a Model for Cardiovascular Medication Stewardship
Cyber-resilient Intensive Care Unit: Ransomware is a Patient-safety Crisis—A Resource-stratified Approach for India
Proton‐Tautomerism Drives Redistribution of Electron Cloud Density in Covalent Organic Framework for Efficient Sodium‐Ion Storage
ABSTRACT Proton tautomerism, a ubiquitous phenomenon involving the dynamic interconversion of structural isomers through proton migration, has seldom been utilized in electrode design. One known example of this untapped potential is the imine‐enamine (─NH─/═N─) equilibrium in conjugated heterocycles. Herein, this reversible process is harnessed to regulate charge transport in covalent organic frameworks (COFs). Two π‐conjugated COFs, HATBQ and HATPT, were constructed via nucleophilic aromatic substitution (SNAr), which integrate dense C═N/C═O redox‐active sites into chemically stable skeletons. The conjugated imine bonds, formed via nucleophilic aromatic substitution, enable the formation of an extensive network of intramolecular hydrogen bonds. This network enhances the crystallinity of the COFs without compromising the reversible proton tautomerism. These combined characteristics endow the COFs, particularly HATPT, with exceptional long‐term cycling stability and rate performance. As a result, HATPT delivers outstanding durability in Sodium‐ ion batteries (SIBs), retaining 225 mAh g −1 after 5000 cycles at 10 A g −1 , and exhibits strong compatibility in full‐cell configurations with Na 3 V 2 (PO 4 ) 3 (NVP). This tautomerism‐driven electronic modulation significantly lowers the activation energy for redox reactions, thereby facilitating efficient Na + storage kinetics.
From Diagnostic Concordance to Implementation-grade Lung Ultrasound in Critical Care
A Cell‐Resolved Ultrastable Biosensor Enables One‐Step Detection of Gene‐Fusion Transcripts in Unprocessed Whole Blood
ABSTRACT Cell‐specific detection of aberrant mRNA in blood is essential for diagnosing and treating hematological malignancies. However, current sensors are unable to function in unprocessed whole blood due to limitations in chemical stability and cell‐targeting capability. Here, we engineer a cell‐resolved ultrastable sensor for hematology (CRUSH) via spherical‐nucleic‐acid (SNA) technology, which enables live‐cell detection of leukemia fusion transcripts in unprocessed whole blood. CRUSH employs stoichiometrically controlled thiol protector to achieve a defect‐free thiol monolayer on AuNPs. This design feature endows CRUSH with a record‐breaking stability, withstanding 0.1 M dithiothreitol, a 10,000‐fold improvement over conventional SNAs. We also demonstrate that the phagocytic bias of myeloid cells over lymphoid cells drives selective internalization of CRUSH in myeloid lineages in whole blood. Leveraging cellular selectivity and engineered stability, CRUSH offers a mixed‐and‐read diagnostic test, where lyophilized sensors are directly mixed with whole blood samples, followed by standard flow cytometry analysis. This one‐step test detects BCR‐ABL1 fusions in living myeloid cells with high specificity and robustness, enabling accurate discrimination of multilineage acute lymphoblastic leukemia within 1 h. Our study bridges biosensing innovation with urgent diagnostic needs, offering a rapid, specific, and robust tool for accurate diagnosis and treatment of hematologic malignancies.
Comparison of Effects of Postextubation Noninvasive Ventilation with Passive Humidification and High-flow Nasal Cannula in Patients with High Risk of Extubation Failure: A Randomized Comparative Study
Highly Selective Methane‐to‐Methanol Conversion Enabled by Bimetallic Nanoclusters Using Molecular Oxygen
ABSTRACT Methane, the most stable alkane, is significantly more stable than its partial oxidation products. This renders the highly selective conversion of CH 4 to CH 3 OH an extremely intractable challenge, especially when using molecular oxygen as the oxidant. In this work, we synthesized a bimetallic‐modified zeolite composite catalyst (PdCo bimetallic nanoclusters supported on H‐ZSM‐5 molecular sieve, denoted as PdCo@H‐ZSM‐5) via a simple impregnation method. PdCo@H‐ZSM‐5 can efficiently activate H 2 and O 2 to highly selectively oxidize CH 4 to CH 3 OH under mild conditions (70°C), achieving a remarkable CH 3 OH yield of 2349 µmol g cat −1 h −1 (249 mmol g Pd −1 h −1 ). Significantly, PdCo@H‐ZSM‐5 is the sole catalyst reported to date that can achieve over 99% CH 3 OH selectivity in the oxidation of CH 4 by molecular oxygen under mild conditions. This work is expected to inspire new technologies for industrial CH 4 to CH 3 OH conversion, promoting more sustainable chemistry and engineering. Furthermore, the low‐energy consumption, high‐efficiency activated oxygen catalyst eliminates the necessity for transporting and storing highly concentrated hydrogen peroxide, serving as a foundation for other green oxidation reactions.