Browse Articles

DNA-Targeted Sonodynamic Activation Enhances Antibacterial Efficacy in Deep and Hypoxic Infections

GEmFakeABSA: graph-embedded fake review detection using aspect-based sentiment analysis

How stakeholder requirements constrain drone-based medical delivery: probabilistic sizing of eVTOL aircraft at high altitude

Abstract Drone-based medical delivery can overcome geographic barriers to healthcare in highland regions, but designing aircraft for this mission requires navigating uncertainty that originates outside engineering: physicians define cold-chain requirements, regulators mandate safety systems, and health planners set delivery speed targets, each imposing design penalties whose magnitudes are uncertain. No existing aircraft sizing framework propagates this requirement-origin uncertainty alongside classical technological uncertainty. Here we introduce Requirement Impact Kits (RIKs)—composable modules with uncertain engineering coefficients—within a three-level probabilistic framework that distinguishes requirement-scenario, engineering-translation, and parameter-level uncertainty. Applied to eVTOL medical delivery at 2,800 m altitude in the Quito Metropolitan District, comparing Lift+Cruise, Tilt-Rotor, and Multirotor architectures, the framework reveals that stakeholder decisions dominate the design space: demanding urgent delivery reduces aircraft feasibility by 24 percentage points—four times the impact of adding cold-chain thermal management. Sobol sensitivity decomposition shows that 98% of parameter-level variance is epistemic and reducible through rotor testing, while battery energy density contributes less than 2%. The Lift+Cruise architecture achieves the highest robustness, and an altitude–cruise speed feasibility map provides health system planners with a quantitative tool for negotiating delivery time requirements against operational reliability.

Morphologically tunable mycelium chips for physical reservoir computing

Patient experiences and perceptions of occupational therapy services in Chinese rehabilitation: a qualitative study

Spatiotemporal trends of foot and mouth disease (FMD) in Bangladesh from 2017 to 2023 and their associations with climatic factors and machine learning (ML) based prediction

Study on the crack propagation mechanism of single cracks in red sandstone based on stress field evolution characteristics

Variety-seeking in joint decisions: the role of reciprocity

Organic-Solvent-Free Weakly Solvating Electrolytes Enable Durable Ah-Scale Zn–Iodine Batteries under Diverse Harsh Operating Conditions

NOP2-mediated m5C methylation impairs mitophagy and aggravates acute lung injury by targeting PINK1

Strong Dipole–Dipole Interaction Promotes Electrocatalytic Acetylene Semihydrogenation over Symmetric Organo-Electrocatalysts

An active learning workflow for predicting misfit volume in body-centered cubic refractory high-entropy alloys

Graded surgical stress reveals postoperative behavioral changes associated with systemic oxidative stress

Sarcopenia modifies the survival benefit of triple therapy versus TACE alone in elderly patients with unresectable hepatocellular carcinoma: A multicenter retrospective cohort study

Physics-informed neural networks with caputo-fabrizio derivatives for nonlinear fractal-fractional delay equations and chaotic systems

Integrated slope stability assessment of earthen canals under seismic loading using pseudostatic analysis and vetiver grass reinforcement

IMSI does not improve pregnancy outcomes and live birth rate in severe teratozoospermia patients: a double-blind randomized controlled trial

Dynamic evaluation of global sustainability: longitudinal ranking and spatial profiling across countries

Excess copper causes repression of global translation in Saccharomyces cerevisiae

Abstract Copper is an essential cofactor for numerous metabolic pathways; however, excess intracellular copper is cytotoxic. In this study, we investigated the consequences of deregulated Cu + uptake mediated by the high-affinity copper transporter Ctr1 in the model yeast Saccharomyces cerevisiae . Constitutive expression of a carboxy-terminally truncated Ctr1 variant, CTR1(300) , resulted in elevated intracellular copper levels, increased oxidative stress, and reduced oxygen consumption, likely due to impairment of iron-sulfur cluster-containing proteins. Notably, CTR1(300) -expressing cells exhibited a pronounced repression of global protein synthesis at very low copper concentrations, a phenotype that was recapitulated in wild-type cells when exposed to higher copper levels. These findings reveal that excessive Cu + accumulation negatively impacts cellular respiration and translation, identifying protein synthesis as a sensitive target of copper toxicity.

Authors’ academic but not personal expertise or gender affect message credibility in science communication

Abstract Evaluating message credibility is critical for understanding scientific information and informed decision making. People’s ability to assess the credibility of science communication texts is influenced by several factors. In three experiments, we examined the impact of authors’ gender as well as different types of expertise on readers’ credibility perceptions. In Experiment 1 (n = 203), we varied authors’ alleged gender and expertise. We found that a text allegedly written by a high-expertise author was rated as more credible than the same text by a low-expertise author. There was no effect of authors’ gender. Experiment 2 (n = 182) was a replication of the first study with a different sample. We did not find any effects of gender or expertise on perceived message credibility. In Experiment 3 (n = 206), we differentiated between academic and personal expertise and manipulated these types of expertise independently. The data indicated that academic expertise was a significant positive predictor of perceived message credibility, while personal expertise was not. We discuss these findings in terms of their significance for the trustworthiness of science communication and examine the relevance of differentiating the concept of expertise in this context.