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Directed Evolution of Nonheme Fe Enzymes for Enantioselective and Regiodivergent 1,3- and 1,4-Nitrogen Migration: Biocatalytic Asymmetric Synthesis of Noncanonical α- and β-Amino Acids
Integrative characterization of the HER2-TLS maturation axis reveals immune heterogeneity and prognostic subtypes in gastric cancer
Dynamic Coordination-Enabled Metal-Dependent Configurational Switching in a Covalent Organic Framework
Seasonality of acute kidney injury incidence in Japanese outpatients
Abstract Acute kidney injury (AKI) is a clinically important condition associated with adverse outcomes. While community-acquired AKI is common, its seasonal patterns remain poorly understood, particularly in outpatient settings. This study aimed to examine the seasonality and community-acquired AKI in Japan. Of 4,401,387 individuals with at least 1 month of data in the Japanese health insurance claims database between August 2016 and July 2018, 4,282,805 were included in the analysis as outpatients. The monthly incidence of community-acquired AKI was evaluated using the incidence rate ratio (IRR) calculated by generalized estimating equations. We constructed multivariable models adjusted for sex, age, comorbidities and medications. There were 20,634 new-onset community-acquired AKI cases. The frequency of new-onset community-acquired AKI gradually increased from June to July, with the highest adjusted IRR in July (1.19 [95% confidence intervals: 1.11–1.27]). Subgroup analyses showed that IRRs for community-acquired AKI were consistently higher in July than in February across all categories. Notably, a significant interaction was observed between seasonality and age ( P = 0.029), with the highest IRR observed in the youngest age group (< 20 years). These results suggest the potential relevance of seasonal and environmental factors in AKI prevention in outpatient settings.
Patchy Membrane-Directed Multiphase Complex Coacervation
Association of urinary diversion type and surgical approach with long-term renal function after radical cystectomy: a nationwide cohort study
Bigger Molecules Enter Smaller Channels of Zeolites via Inward-Coil-Alike Adaptation
A global–local hybrid transformer framework for automatic Navarasa facial expression recognition
Discovery of Noninhibitory Macrocyclic Ligands for Protein Tyrosine Phosphatase 1B Using a Function-Based, Iterative Screening Strategy
Prevalence and associated factors of pre-cancerous cervical lesions among HIV-positive women on ART in Northwest Ethiopia: a retrospective cross-sectional study
Abstract Cervical cancer is a major public health concern in Ethiopia with high mortality rates, especially in women living with HIV/AIDS. While its screening service has been available in Ethiopia since 2009, the updated prevalence of precancerous cervical lesions among HIV-positive women is not well understood. Therefore, this study aimed to determine the prevalence of precancerous cervical lesions and its associated factors among women living with HIV receiving ART in the Northwest Ethiopia. An institution-based retrospective cross-sectional study was conducted from February 28 to April 1, 2024 at the University of Gondar Comprehensive Specialized Hospital. A total of 419 eligible participants were selected by using simple random sampling technique. The data were collected through patient chart review using a pre-tested and structured checklist. The data were entered into Epi-info version 7, cleaned, and analyzed using SPSS version 20. Binary logistic regression model was used to identify factors associated with the outcome variable, and odds ratios with 95% confidence intervals and its corresponding p-values were computed to identify significant variables in the multivariable analysis. In this study, the prevalence of precancerous cervical lesions was found to be 11.5% (95% CI: 8.2–14.7). History of STI (AOR = 3.7, 95% CI: 1.79–7.62), age at first marriage less than 15 years (AOR = 3.02, 95% CI: (1.00-9.24), monthly income below 3000 Ethiopian Birr (AOR = 6.3, 95% CI: 1.20-32.82), and being widowed (AOR = 0.36, 95% CI: 0.13–0.95) were factors significantly associated with the occurrence of precancerous cervical lesions. The present study revealed 11.5% of precancerous cervical lesions among women living with HIV. History of sexually transmitted infections (STIs), early marriage, low income level, and being widowed were significantly associated with the outcome variable. Therefore, targeted interventions such as delaying early marriage and strengthening strategies that promote protection against sexually transmitted infections and poverty are recommended to reduce the burden of the disease in this highly vulnerable population.
Exciton Selectively Coupled to Magnon Dependent on Spin–Lattice Alignment
Dual-fluorescence reporter-based assay for rapid quantitative evaluation of antiviral activity against Venezuelan equine encephalitis virus
Anomalous Solubility-Inverted Behavior of LiPF <sub>6</sub> in Glyme Ether Solvents for High-Voltage Electrochemistry
Resilient fixed-order damping controller for low-frequency inter-area oscillations in power systems under communication failures
Abstract Low-frequency inter-area oscillations (LFOs) pose a critical challenge to small-signal stability, affecting the reliable operation of interconnected power systems. These oscillations can reduce tie-line power transfer capability and weaken overall system performance. This paper proposes, for the first time, a robust fixed low-order two-input single-output (TISO) damping controller based on dual wide-area signals to mitigate the effects of communication failures and time delays on system stability. Inter-area modes can be effectively observed from multiple locations and controlled from a single point, which motivates the use of a wide-area damping controller (WADC). Communication failures and time delays are important challenges in wide-area control, and delays are modeled using the Padé approximation. The controller is designed by optimizing key performance measures, such as the $$H_{\infty }$$ norm, spectral abscissa, and complex stability radius, to improve the robustness and stability of the system under uncertain conditions. The proposed controller improves system resilience by using the two most observable wide-area signals associated with critical inter-area modes. Kundur’s 11-bus system and the IEEE 39-bus test system are used to validate the proposed method. Simulation results show that the controller effectively improves the damping of inter-area oscillations under normal conditions and maintains stable performance even in the presence of communication failures and delays.