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Very low prevalence of Plasmodium falciparum histidine-rich protein 2 (pfhrp2) gene deletion in the Brazil, Venezuela, and Guyana tri-border
Abstract Rapid Diagnostic Tests (RDTs) have been an important diagnostic tool for detecting P. falciparum malaria in resource-limited settings. Most tests are designed to detect the Histidine-rich Protein 2 (HRP2). Parasites lacking pfhrp2 and its homologous pfhrp3 have been reported in several regions, with prevalence reaching 100% in certain areas. To better characterize P. falciparum isolates circulating in the Brazil-Venezuela-Guyana tri-border region, we performed a comprehensive analysis of 365 samples collected between 2016 and 2018. Molecular and immunological methods were employed to detect HRP2 and confirm pfhrp2/3 deletions. Our findings point to a low prevalence (1%) of pfhrp2 -deleted parasites confirmed by the lack of HRP2 detection. Among false-negative HRP2-RDT tests (6%), most were attributed to low parasite densities. A merozoite surface protein 2 ( msp2 )-based intra-host diversity analysis suggested overall low genetic diversity. The pattern of HRP2 sequences resembled that has been previously described in areas along the Brazil and French Guiana border. In conclusion, we have found a low prevalence of pfhrp2 -deleted parasites in the north-central Guiana Shield, which contrasts with the findings reported at the Peru border. Continued surveys are necessary to monitor the prevalence of pfhrp2 deletion in this area characterized by a high number of cross-border malaria cases.
Reductive sulfinylation by nucleophilic chain isomerization of sulfonylpyridinium
Correction: Music listening evokes story-like visual imagery with both idiosyncratic and shared content
Cinnamic acid conjugated with triazole acetamides as anti-Alzheimer and anti-melanogenesis candidates: an in vitro and in silico study
regionalpcs improve discovery of DNA methylation associations with complex traits
Spatiotemporal patterns in active four-state Potts models
Lignin alkali regulated interfacial polymerization towards ultra-selective and highly permeable nanofiltration membrane
Study on the foam production characteristics of air self-suction foam generator by jet
Entropy engineering activation of UiO-66 for boosting catalytic transfer hydrogenation
Biparametric MRI-based radiomics for noninvastive discrimination of benign prostatic hyperplasia nodules (BPH) and prostate cancer nodules: a bio-centric retrospective cohort study
Cryo-EM structure and oligomerization of the human planar cell polarity core protein Vangl1
Faces of different socio-cultural identities impact emotional meaning learning for L2 words
Mechanistic evaluation of enhanced graphene toxicity to Bacillus induced by humic acid adsorption
Optimizing solar performance of CFTSe-based solar cells using MoSe2 as an innovative buffer layers
AbstractIn this study, we explore the photovoltaic performance of an innovative high efficiency heterostructure utilizing the quaternary semiconductor Cu2FeSnSe4 (CFTSe). This material features a kesterite symmetrical structure and is distinguished by its non-toxic nature and abundant presence in the earth’s crust. Utilizing the SCAPS simulator, we explore various electrical specifications such as short circuit current (Jsc), open circuit voltage (Voc), the fill factor (FF), and power conversion efficiency (PCE) were explored at a large range of thicknesses, and the acceptor carrier concentration doping (NA). Our results demonstrate that optimized parameters yield a remarkable PCE of 26.47%, accompanied by a Voc of 1.194 V, Jsc of 35.37 mA/cm2, and FF of 62.65% at a CFTSe absorber thickness of 0.5 μm. Furthermore, the performance of the photovoltaic cell is assessed for the defect levels in the CFTSe absorber and MoSe2 buffer layers. Results indicate that deep defect levels above 1 × 1017 cm− 3 lead to a decrease in Jsc. The study also investigates the effect of operating temperature on cell performance within the 300–500 K range. A notable decline in Voc is observed, likely due to an increase in saturation current, suggesting an interaction between temperature and cell behavior. In this work, we propose a practical CFTSe-based structure that replaces conventional buffer layers, such as CdS, with MoSe2 TMDC as a promising alternative buffer layer, paving the way for more sustainable solar technology.