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Development and characterization of in vitro inducible immortalization of a murine microglia cell line for high throughput studies
Atmospheric air plasma pre-activation and customizable covalent functionalization of PVDF-membranes of microtiter filter plates
Abstract Microtiter-plate-based systems are unified platforms of high-throughput experimentation (HTE). These polymeric devices are used worldwide on a daily basis—mainly in the pharmaceutical industry—for parallel syntheses, reaction optimization, various preclinical studies and high-throughput screening methods. Accordingly, laboratory automation today aims to handle these commercially available multiwell plates, making developments focused on their modifications a priority area of modern applied research. We performed the covalent functionalization of the porous PVDF-membrane of microtiter filter plates as the essence of conventional and common sandwich plate systems by introducing a generalizable method. After surface-activation of the indifferent membrane polymer, customizable functionalization becomes feasible by covalently attached monofunctional molecular linkers. The study was designed with future adaptability, and thus, industrially widespread atmospheric plasma and two different chemical treatments were investigated and compared in terms of practical implementation, polarization effects, extent of labeling, effects on morphology and porosity as well as on permeability. For critical comparison, contact angle measurements, surface ATR-FTIR, 1H-NMR, 19F-NMR, UV–Vis spectroscopy, scanning electron microscopy and permeability tests were used.
3D nanocomposites of β-TCP-H3BO3-Cu with improved mechanical and biological performances for bone regeneration applications
Access to HIV testing and factors associated among sexual minority women in a metropolitan region of the Brazilian Amazon
Evidence of genetic determination of annual movement strategies in medium-sized raptors
Effects of a 16-week dance intervention on loneliness and self-esteem in left behind children: a randomised controlled trial
A vision model for automated frozen tuna processing
Optimization of metal polymer friction pair composition for hydrogen wear reduction through thermal stabilization analysis
Abstract The composition of the metal-polymer friction pair is carefully considered for interacting with water and hydrogen, ensuring the metals electrode process potential remains below waters in a neutral medium. Simultaneously, adherence to defined chemical composition ratios for the metal-polymer materials is crucial. This analysis is conducted under conditions of thermal stabilization, characterized by a minimal temperature gradient across the rim thickness within an equivalent thermal field. Using the quasi-chemical approximation, the paper derives a concentration-dependent diffusion coefficient of hydrogen (H) in iron (Fe) across a broad spectrum. This derivation includes electronic and vibrational contributions to the chemical potential. The research establishes a correlation between the equivalent diffusion coefficient and the concentration of diffusing hydrogen atoms from the metal, such as the pulley or drum rim. These findings offer novel insights into optimizing hydrogen wear behaviour in brake friction couples, contributing to advancements in materials and design considerations in the automotive field.