Browse Articles
Discover research articles across all indexed journals
Time in therapeutic range of tacrolimus in allogeneic hematopoietic stem cell transplant recipients is associated with acute graft-versus-host disease prophylaxis
Typhoon localization detection algorithm based on TGE-YOLO
Privacy-preserving approach for IoT networks using statistical learning with optimization algorithm on high-dimensional big data environment
Unsupervised data imputation with multiple importance sampling variational autoencoders
Cardiovascular disease attenuates the protective effect of folate on global cognitive function in an elderly population: a cross-sectional study
Preserved ratio impaired spirometry, airflow obstruction, and their trajectories in relationship to chronic kidney disease: a prospective cohort study
UHRF1 promotes epithelial-mesenchymal transition mediating renal fibrosis by activating the TGF-β/SMAD signaling pathway
Identification of ubiquitination-related key biomarkers and immune infiltration in Crohn’s disease by bioinformatics analysis and machine learning
Laser-based 3D printing and optical characterization of optical micro-nanostructures inspired by nocturnal insects compound eyes
A machine learning technique for optimizing load demand prediction within air conditioning systems utilizing GRU/IASO model
A retrospective analysis on maternal and neonatal outcomes in pSS/AITD pregnancies
Modelling of P-wave velocity changes in coal seams with increased depth: a case study
Abstract Seismic profiling in a coal seam enables the determination of anomalous changes in the P-wave velocity compared to reference velocity at a specific mining depth, indicating potential stress changes. This information can improve the coal exploitation processes in advance at greater depths, especially in seismic hazard areas. This study aims to update the empirical mathematical formula for calculating reference P-wave velocities in coal seams by including new data measured at greater depths. The research was performed at the Zofiówka Coal Mine in the geological and mining conditions of the Upper Silesian Coal Basin in Poland. The analysis involved the study of 276 velocity values including 24 new velocity values measured at depths ranging from 704 to 1073 metres in the period 2009–2024. Through regression analysis, the standard model was modified. The new model provides more reliable velocity anomaly calculations and accurately reflects the geomechanical conditions at greater depths in the Zofiówka Coal Mine. The calculation procedure can be utilised to develop velocity models for various geological and geomechanical conditions in underground mines that exploit coal seams at continuously increasing depths.
Tailoring and characterization of bioactive graft material for alveolar bone preservation and regeneration in fresh extraction sockets of dog model
Abstract The objective of this study was to tailor an osteoinductive scaffold for alveolar bone regeneration and around immediately placed implants in extraction sockets of dogs. Tailored amorphous multiporous bioactive glass (TAMP -BG) was prepared and characterized for bioactivity and response of human alveolar bone marrow mesenchymal stem cells (hABMSCs). Extraction sockets of twenty-two male mongrel dogs received TAMP-BG in the right side around implant in the distal socket of the mandibular fourth premolar (P4), while the adjacent empty mesial socket of the same tooth was filled with the same graft. Autologous bone chips were used in the left side. Animals were euthanized at 1, 2, 4, 8 &12 weeks for histological and SEM analyses. SEM/EDX, FTIR and XRD analyses displayed formation of a bioactive hydroxycarbonated apatite layer. TAMP-BG significantly increased proliferation and migration of hABMSCs. Histologically, at the 1st week, advanced bone healing was shown in TAMP-BG group. At four weeks bone density was significantly higher forTAMP-BG (92.71% ± 1.71) versus control (62.92% ± 2.02) (P = 0.0001).At eight weeks, significant increase in width of buccal plate and height of lingual bony plate was observedfor TAMP-BG grafted implant.The socket orifice width significantly decreased for autologous bone from 1 to 12 weeks (P < 0.001), while it significantly increased for TAMP-BG (P = 0.03). We conclude that TAMP-BG can provide a preservative dynamic microenvironment following extraction up to three months which can be attributed to its unique physico-chemical characteristics.
A novel uORF regulates folliculin to promote cell growth and lysosomal biogenesis during cardiac stress
Abstract Pathological cardiac remodeling is a maladaptive response that leads to changes in the size, structure, and function of the heart. These changes occur due to an acute or chronic stress on the heart and involve a complex interplay of hemodynamic, neurohormonal and molecular factors. As a critical regulator of cell growth, protein synthesis and autophagy mechanistic target of rapamycin complex 1 (mTORC1) is an important mediator of pathological cardiac remodeling. The tumor suppressor folliculin (FLCN) is part of the network regulating non-canonical mTORC1 activity. FLCN activates mTORC1 by functioning as a guanosine triphosphatase activating protein (GAP). Our work has identified a regulatory upstream open reading frame (uORF) localized in the 5′UTR of the FLCN mRNA. These small genetic elements are important regulators of protein expression. They are particularly important for the regulation of stress-responsive protein synthesis. We have studied the relevance of the FLCN uORF in the regulation of FLCN translation. We show that FLCN downregulation through the uORF is linked to cardiomyocyte growth and increased lysosomal activity. In summary, we have identified uORF-mediated control of RNA translation as another layer of regulation in the complex molecular network controlling cardiomyocyte hypertrophy.