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Author Correction: Dual quantum cascade lasers for noninvasive glucose detection using photoacoustic spectroscopy
Activation of endogenous full-length utrophin by MyoAAV-UA as a therapeutic approach for Duchenne muscular dystrophy
Exploring resistive switching in flexible, forming-free Ti/NiO/AZO/PET memory device for future wearable electronics
Systematic analysis of cotranscriptional RNA folding using transcription elongation complex display
Cloning and expression analysis of RhHsf24 gene in Rose (Rosa hybrida)
Berberine-inspired ionizable lipid for self-structure stabilization and brain targeting delivery of nucleic acid therapeutics
Use of the vessel sealer in paraaortic lymphadenectomy in the robotic assisted approach in endometrial cancer
How to stop being surprised by unprecedented weather
Abstract We see unprecedented weather causing widespread impacts across the world. In this perspective, we provide an overview of methods that help anticipate unprecedented weather hazards that can contribute to stop being surprised. We then discuss disaster management and climate adaptation practices, their gaps, and how the methods to anticipate unprecedented weather may help build resilience. We stimulate thinking about transformative adaptation as a foundation for long-term resilience to unprecedented weather, supported by incremental adaptation through upgrading existing infrastructure, and reactive adaptation through short-term early action and disaster response. Because in the end, we should take responsibility to build resilience rather than being surprised by unprecedented weather.
An improved transformer based traffic flow prediction model
Tebentafusp, a T cell engager, promotes macrophage reprogramming and in combination with IL-2 overcomes macrophage immunosuppression in cancer
Egg intake in relation to metabolic health status, serum brain derived neurotrophic factor, and adropin levels in Iranian adults
Enzyme-activating B-cell receptors boost antigen presentation to pathogenic T cells in gluten-sensitive autoimmunity
Abstract Autoantibodies against the enzyme transglutaminase 3 (TG3) are characteristic to the gluten-sensitive skin disorder dermatitis herpetiformis (DH), which is an extraintestinal manifestation of celiac disease. We here demonstrate that TG3-specific B cells can activate gluten-specific CD4+ T cells through B-cell receptor (BCR)-mediated internalization of TG3-gluten enzyme-substrate complexes. Stereotypic anti-TG3 antibodies using IGHV2-5/IGKV4-1 gene segments enhance the catalytic activity of TG3, and this effect translates into increased gluten presentation to T cells when such antibodies are expressed as BCRs. The crystal structure of TG3 bound to an IGHV2-5/IGKV4-1 Fab shows that antibody binding to a β-sheet in the catalytic core domain causes the enzyme to adopt the active conformation. This mechanism explains the production of stereotypic anti-TG3 autoantibodies in DH and highlights a role for TG3-specific B cells as antigen-presenting cells for gluten-specific T cells. Similar boosting effects of autoreactive BCRs could be relevant for other autoimmune diseases, including rheumatoid arthritis.
Molecular dynamics simulation of palmitic acid molecular passivation affecting the surface activity of aluminum nanoparticles
Edge-guided inverse design of digital metamaterial-based mode multiplexers for high-capacity multi-dimensional optical interconnect
A hybrid approach for lithium-ion battery remaining useful life prediction using signal decomposition and machine learning
Rare pathogenic structural variants show potential to enhance prostate cancer germline testing for African men
Abstract Prostate cancer (PCa) is highly heritable, with men of African ancestry at greatest risk and associated lethality. Lack of representation in genomic data means germline testing guidelines exclude for Africans. Established that structural variations (SVs) are major contributors to human disease and prostate tumourigenesis, their role is under-appreciated in familial and therapeutic testing. Utilising clinico-methodologically matched deep-sequenced whole-genome data for 113 African versus 57 European PCa patients, we interrogate 42,966 high-quality germline SVs using a best-fit pathogenicity prediction workflow. We identify 15 potentially pathogenic SVs representing 12.4% African and 7.0% European patients, of which 72% and 86% met germline testing standard-of-care recommendations, respectively. Notable African-specific loss-of-function gene candidates include DNA damage repair MLH1 and BARD1 and tumour suppressors FOXP1, WASF1 and RB1 . Representing only a fraction of the vast African diaspora, this study raises considerations with respect to the contribution of kilo-to-mega-base rare variants to PCa pathogenicity and African-associated disparity.
Spatial-temporal modeling of urban resilience and risk to earthquakes
Electrochemical cobalt-catalyzed semi-deuteration of alkynes to access deuterated Z-alkenes
Abstract Deuterium labeling has found extensive applications across various research fields, including organic synthesis, drug design, and molecular imaging. Electrocatalytic semi-hydrogenation of alkynes offers a viable route for the synthesis of Z-alkenes, yet it falls short in achieving the semi-deuteration of these compounds. In this study, we report an electrochemical cobalt-catalyzed transfer deuteration reaction that proficiently accomplishes the semi-deuteration of alkynes, yielding Z-configuration deuterated alkene products. This reaction utilizes cost-effective cobalt salts as catalysts and employs D2O and AcOD (acetic acid-d) as economical and efficient deuterium sources, underscoring its practicality and feasibility. The reaction demonstrates a broad alkyne substrate scope, high reaction efficiency, good functional group compatibility, excellent Z-selectivity, and a remarkable degree of deuteration rate.