Browse Articles
Discover research articles across all indexed journals
Aging macaques bridge the translational gap in perivascular space biology
Efferocytosis of apoptotic bodies drives SARS-CoV-2 infection and macrophage inflammation
Molecular interactions, solubility, and cytotoxic activity of 4‑hydroxycoumarin in choline chloride‑based acidic deep eutectic solvents
Abstract This study systematically investigated the solubility enhancement of 4-hydroxycoumarin (4HC), a poorly water-soluble pharmaceutical compound, in three novel acidic deep eutectic solvents (ADESs) prepared from choline chloride (ChCl) and acidic hydrogen bond donors encompassing propionic acid (Pro), acetic acid (Ace) and lactic acid (Lac). The solubility measurements were conducted Appling the shake-flask method at 298.15–313.15 K. The ChCl/Pro system exhibited unprecedented more than 500-fold solubility improvement over the pure water, with solubility Increasing in the order: ChCl/Pro > ChCl/Ace > ChCl/Lac. Hansen Solubility Parameters (HSPs) analysis confirmed hydrogen bonding and acidity as dominant dissolution factors. In addition, advanced thermodynamic models (Wilson, e-NRTL, UNIQUAC) accurately correlated experimental solubility data, with the Wilson model achieving ARD percentage values as low as 0.10%. Thermodynamic analysis revealed the dissolution process is endothermic and enthalpy-driven. MTT cytotoxicity assays on HT29 colon cancer cells demonstrated IC₅₀ values in the 20–100 µg/mL range, with differential cytotoxicity correlated to solvent composition. These findings identify ChCl/Pro as the optimal ADES candidate (500-fold solubility enhancement, IC 50 20–100 µg/mL range) for preformulation development of 4HC, establishing a data-driven foundation for green solvent-based pharmaceutical applications.
Iodine-mediated proton-coupled electron transfer enables selective polymerization of organic pollutants in an oxidant-free electrocatalytic system
Precise estimation of rice leaf macro and micro nutrients from multi-spectral images using neural architecture search with polynomial approximation functions
Speech as a biomarker for supported diagnosis of major depressive disorder using self-supervised representations
Simulation based learning as a strategy for patient education training in medical students
Liposomal mitoxantrone plus tislelizumab in patients with relapsed or refractory extranodal natural killer/T-cell lymphoma: a phase 1b/2 trial
Human papillomavirus vaccination: knowledge, acceptance, and barriers among medical students. An Egyptian multicenter cross sectional study
Abstract Human papillomavirus (HPV) infection is a major public health concern and a leading cause of cervical cancer worldwide. Despite the availability of effective vaccines, awareness and vaccine acceptance remain limited in many developing countries. This study aimed to assess awareness, acceptance, barriers, and determinants of HPV vaccination among medical students in Egypt. A web-based multicentre cross-sectional study was conducted among undergraduate medical students from governmental, national, and private medical faculties across Egypt using a non-probability sampling approach (convenience and snowball sampling). Data were collected using a validated structured questionnaire. A total of 601 students participated in the study. 31.4% were unaware that HPV is available for both males and females, and half of them expressed negative attitudes and concerns regarding the novelty (44%), safety (56%), efficacy (59%), and cost of the vaccine (51.7%). Nearly half (48.3%) of them were unaware that the “HPV vaccine” is available in Egypt. Seventy-three students (12.1%) received the vaccine, and among vaccinated participants, 39 were males. In addition, 44.3% of students reported hesitancy toward HPV vaccination, while 58.9% indicated willingness to receive the vaccine if it was provided free of charge. Family history of cervical cancer, total knowledge, and attitude scores were significant predictors of participants’ HPV vaccine uptake ( p < 0.05). Nearly half of the participants had not taken the vaccine because they were not sexually active or they lacked knowledge. Unfortunately, about one-third of the participants didn’t take the vaccine because of cultural and parental objections. Male participants were less likely to recommend the vaccine to others. In spite of being medical students, their knowledge and attitudes were less than expected, giving an idea about the public situation. Findings underscore the importance of educational campaigns to raise knowledge and change faulty beliefs, focusing on the target groups and their parents. Also, the national health authorities should allocate resources to make the HPV vaccine available, accessible, and affordable.
Lipid trapping slows ball-and-chain inactivation in a calcium-activated potassium channel
Buried-interface stabilization for efficient and bright blue perovskite LEDs
Distinguishing intrinsic and interfacial pyroelectric effects by polarization reversal measurements
Biomass-based thermally tunable dual afterglow with room temperature daylight visibility
Observation of tunable chiral spin textures with nonlinear optics
Abstract Chiral spin textures, such as spin spirals and skyrmions, are key to advancing spintronics by enabling ultrathin, energy-efficient memory, and high-density data storage and processing. However, their realization remains hindered by the scarcity of suitable host materials and the formidable experimental challenges associated with the characterization of these intricate chiral magnetic states. Here, we report the observation of tunable chiral magnetic textures in van der Waals magnet CrPS 4 with nonlinear optics. These tunable textures exhibit strong chiral third-order nonlinear optical responses, driven by interlayer and intralayer spin couplings under varying magnetic fields and temperatures. These pronounced chiral nonlinear optical responses highlight the potency and high sensitivity of the nonlinear optical readout for probing non-collinear magnetic orders. Moreover, our findings position van der Waals magnets and their heterostructures as an exceptional platform for reconfigurable spin-photonics and spintronics, unifying optical, electrical, and magnetic properties through unique intralayer and interlayer spin coupling properties and effective spin interaction between photons and electrons.