Browse Articles

Enantioselective Total Synthesis of Fortalpinoid Q via a TEMPO⁺BF₄^–-Mediated Dehydrative Nazarov Cyclization

Intrinsic Ion Concentration Difference Induced Antipolyelectrolyte Effect for Promoting Stability of Zn Anodes

Deciphering the Competitive Charge Storage Chemistry of Metal Cations and Protons in Aqueous MnO₂-Based Supercapacitors

Correction to “Revolutionizing CO₂ Electrolysis: Fluent Gas Transportation within Hydrophobic Porous Cu₂O”

Daily briefing: About 1% of children have genetic paternity other than that recorded by history

Electrochemical N–N Oxidatively Coupled Dehydrogenation of 3,5-Diamino-1<i>H</i>-1,2,4-triazole for Value-Added Chemicals and Bipolar Hydrogen Production

Rigidity Reinforcement of 3D Covalent Organic Frameworks by Controlling Interpenetration

Comparative structural insights and functional analysis for the distinct unbound states of Human AGO proteins

Abstract The four human Argonaute (AGO) proteins, critical in RNA interference and gene regulation, exhibit high sequence and structural similarity but differ functionally. We investigated the underexplored structural relationships of these paralogs through microsecond-scale molecular dynamics simulations. Our findings reveal that AGO proteins adopt similar, yet unsynchronized, open-close states. We observed similar and unique local conformations, interdomain distances and intramolecular interactions. Conformational differences at GW182/ZSWIM8 interaction sites and in catalytic/pseudo-catalytic tetrads were minimal. Tetrads display conserved movements, interacting with distant miRNA binding residues. We pinpointed long common protein subsequences with consistent molecular movement but varying solvent accessibility per AGO. We observed diverse conformational patterns at the post-transcriptional sites of the AGOs, except for AGO4. By combining simulation data with large datasets of experimental structures and AlphaFold’s predictions, we identified proteins with genomic and proteomic similarities. Some of the identified proteins operate in the mitosis pathway, sharing mitosis-related interactors and miRNA targets. Additionally, we suggest that AGOs interact with a mitosis initiator, zinc ion, by predicting potential binding sites and detecting structurally similar proteins with the same function. These findings further advance our understanding for the human AGO protein family and their role in central cellular processes.

Extreme pH Tolerance in Peptide Coacervates Mediated by Multivalent Hydrogen Bonds for Enzyme-Triggered Oral Drug Delivery

Predictive efficacy of different diagnostic criteria for sarcopenia in osteoporosis and fractures

Why humans have puzzle-shaped cells

Solid-State NMR Spectroscopy Investigation of Structural Changes of Mechanically Strained Mouse Tail Tendons

Peptidomics characteristics of pediatric sepsis

Postoperative longer leg on surgical side and high riding greater trochanter worsen forgotten joint score after unilateral total hip arthroplasty

Could libraries band together to ensure open access for all?

Observation of Dynamic Aggregation Behavior in Thermoresponsive Micro- and Nanoparticles via Diffusion-Ordered NMR Spectroscopy

Insights into the terminal pleistocene climate of Australia from high resolution climate modelling

Unraveling Dynamic Structural Evolution of Single Atom Catalyst <i>via In Situ</i> Surface-Enhanced Infrared Absorption Spectroscopy

Novelty of harnessing electromagnetic fields to boost graphene oxide nano particles antibacterial potency

Abstract The urge need for innovative integration between Electromagnetic Waves (EMWs) and nanotechnology offers exciting possibilities for improving antimicrobial treatments to combat antibacterial resistant bacterial infections. This study explores how EMWs at range below 300 Hz can enhance the antibacterial efficacy of Graphene Oxide Nanoparticles (GONPs) against Pseudomonas aeruginosa, a significant pathogen in antibiotic resistance. EMWs at range below 300 Hz, interact with bacterial cell membranes to affect ion channels, permeability, and cellular signaling, offering a non-invasive method to amplify antimicrobial effects. GONPs synthesized through glucose pyrolysis and characterized by X-ray diffraction, UV-visible spectroscopy, high-resolution transmission electron microscopy, and Fourier-transform infrared spectroscopy, exhibit potent antibacterial properties due to their sharp edges, large surface area, and ability to generate Reactive Oxygen Species (ROS). These nanoparticles disrupt bacterial membranes, form biofilms, and damage cellular components through oxidative stress. The study examines how those EMWs can enhance GONP penetration into bacterial cells, increase ROS production, and disrupt biofilms. By optimizing EMWs parameters such as frequency, intensity, and duration this research aims to develop new, non-invasive antibacterial therapies. The results could lead to advanced antimicrobial strategies, integrating nanotechnology with electromagnetic field exposure, offering innovative solutions to address antibiotic-resistant infections and improve treatment efficacy. This approach represents a significant step toward more effective, targeted antibacterial therapies.

Photochemical Pathways and Light-Enhanced Radical Scavenging Activity of 1,8-Dihydroxynaphthalene Allomelanin