Gut microbiota-dependent 24-hydroxycholesterol metabolism contributes to capsaicin-induced amelioration of Alzheimer’s disease-like pathology in mice

Y Yawen Li H Hui Wang D Dongyuan Zhang (National Engineering Research Center of Industrial Enzymes) S Shiqi Wang Z Zheng Li J Jingjie Li S Shentao Tai D Dandan Tong B Bifeng Wang D Dingbing Lu S Shulu Yuan W Weiqi Sun B Biyu Yang (State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica) C Chaobo Bai Q Qi Wang J Jiuyang Ding Z Zhihao Wang (Center for Low-Carbon Conversion Science and Engineering; State Key Laboratory of Low Carbon Catalysis and Carbon Dioxide Utilization, Shanghai Advanced Research Institute) Y Yang Gao H Haitao Yu K Kun Cui C Chang Liu J Jian Mao Y Yun Yao F Fengyu Liu (Key Laboratory of Biomimetic Robots and Systems, Ministry of Education, State Key Laboratory of Intelligent Control and Decision of Complex System, and School of Mechatronics Engineering, Beijing Institute of Technology) Y You Wan J Junliang Yuan X Xuemei Liu J Jie Zheng (Key Laboratory of Radiation Physics and Technology, Ministry of Education, Institute of Nuclear Science and Technology)

Article Details

Volume / Issue Vol. 17, Issue 1
Published February 03, 2026
ISSN 2041-1723
Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (28)

Y

Yawen Li

H

Hui Wang

D

Dongyuan Zhang

National Engineering Research Center of Industrial Enzymes

S

Shiqi Wang

Z

Zheng Li

J

Jingjie Li

S

Shentao Tai

D

Dandan Tong

B

Bifeng Wang

D

Dingbing Lu

S

Shulu Yuan

W

Weiqi Sun

B

Biyu Yang

State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica

C

Chaobo Bai

Q

Qi Wang

J

Jiuyang Ding

Z

Zhihao Wang

Center for Low-Carbon Conversion Science and Engineering; State Key Laboratory of Low Carbon Catalysis and Carbon Dioxide Utilization, Shanghai Advanced Research Institute

Y

Yang Gao

H

Haitao Yu

K

Kun Cui

C

Chang Liu

J

Jian Mao

Y

Yun Yao

F

Fengyu Liu

Key Laboratory of Biomimetic Robots and Systems, Ministry of Education, State Key Laboratory of Intelligent Control and Decision of Complex System, and School of Mechatronics Engineering, Beijing Institute of Technology

Y

You Wan

J

Junliang Yuan

X

Xuemei Liu

J

Jie Zheng

Key Laboratory of Radiation Physics and Technology, Ministry of Education, Institute of Nuclear Science and Technology