Distal mutations enhance catalysis in designed enzymes by facilitating substrate binding and product release
N
Niayesh Zarifi
(Department of Chemistry and Biomolecular Sciences)
P
Pooja Asthana
H
Hiva Doustmohammadi
C
Cindy Klaus
(Department of Chemistry and Biomolecular Sciences)
J
Janet Sanchez
S
Serena E. Hunt
(Department of Chemistry and Biomolecular Sciences)
R
Rojo V. Rakotoharisoa
S
Sílvia Osuna
J
James S. Fraser
R
Roberto A. Chica
(Department of Chemistry and Biomolecular Sciences)
Article Details
Journal
Nature Communications
Volume / Issue
Vol. 16, Issue 1
Published
September 30, 2025
ISSN
2041-1723
Publisher
Nature Portfolio
Authors (10)
N
Niayesh Zarifi
Department of Chemistry and Biomolecular Sciences
P
Pooja Asthana
H
Hiva Doustmohammadi
C
Cindy Klaus
Department of Chemistry and Biomolecular Sciences
J
Janet Sanchez
S
Serena E. Hunt
Department of Chemistry and Biomolecular Sciences
R
Rojo V. Rakotoharisoa
S
Sílvia Osuna
J
James S. Fraser
R
Roberto A. Chica
Department of Chemistry and Biomolecular Sciences
Related Articles from this Journal
Synthesis of adaptive 15N-nitrosyl-Co7 nanocluster for electrocatalytic C–H functionalization
Chao Wu, Xu Zhang et al.
Aug 2026
10.1038/s41467-026-76516-1
Pan-Ebolavirus nanoparticle vaccine provides protection in rodents from lethal infection by Zaire and Sudan viruses
Connor Weidle, Natalie Brunette et al.
Aug 2026
10.1038/s41467-026-76114-1
Multi-population GWAS meta-analysis identifies bladder cancer susceptibility loci and highlights genetic regulation of smoking-related risk
Ludmila Prokunina-Olsson, Oscar Florez-Vargas et al.
Aug 2026
10.1038/s41467-026-76157-4
Genome-wide annotation of human multi-nucleotide variants reveals widespread functional differences from single nucleotide variants
Weiwei Jin, Wen Cao et al.
Aug 2026
10.1038/s41467-026-76470-y
Allele-specific chromatin architecture shapes imprinted domains and coordinates a distal enhancer and antisense transcription at the mouse Mest-Copg2 domain
Bongmin Bae, Katherine Gu et al.
Aug 2026
10.1038/s41467-026-76506-3