Zarifi, N., Asthana, P., Doustmohammadi, H., Klaus, C., Sanchez, J., Hunt, S. E., Rakotoharisoa, R. V., Osuna, S., Fraser, J. S., Chica, R. A. (2025). Distal mutations enhance catalysis in designed enzymes by facilitating substrate binding and product release. Nature Communications. https://doi.org/10.1038/s41467-025-63802-7