Scientific Reports
Articles in this Issue
Identifying RAGE inhibitors as potential therapeutics for Alzheimer’s disease via integrated in-silico approaches
Efficacy and safety of trastuzumab deruxtecan in HER2-positive breast cancer patients with brain metastases after failure of pyrotinib-based therapy
Training in normobaric hypoxia induces hematological changes that affect iron metabolism and immunity
Abstract Altitude training is a method among endurance athletes to enhance performance via hypoxia-induced adaptations. However, individual responses vary signif...
Identification of non-charged 7.44 analogs interacting with the NHR2 domain of RUNX1-ETO with improved antiproliferative effect in RUNX-ETO positive cells
Abstract The RUNX1/ETO fusion protein is a chimeric transcription factor in acute myeloid leukemia (AML) created by chromosomal translocation t(8;21)(q22;q22). t(8;21) abnormality is associa...
Suitability analysis to determine optimal locations of local community radio transmitters using GIS and remote sensing: a case study of Chipinge district, Zimbabwe
Adjusting vector surveillance for human behaviors reveals Anopheles funestus drove a resurgence in malaria despite IRS with clothianidin in Uganda
Abstract After remarkable success following the implementation of indoor residual spraying (IRS) and repeated rounds of universal distribution of insecticidal treated nets in Tororo District...
Unstable laboratory Wolbachia strain w-Anga is negatively correlated with Plasmodium falciparum in wild malaria vectors
Innovative vibriosis control in open aquaculture: Paratapes undulata as a sustainable growth and resistance enhancer in red tilapia
Abstract This study demonstrates the novel therapeutic potential of Paratapes undulata for mitigating Vibrio alginolyticus infection in red tilapia. In vivo, P. undulata significantly improv...
Exosomes derived from M2 macrophage promote HUVECs proliferation, migration and tube formation in vitro
Abstract Angiogenesis is one of the hallmarks of solid tumors. Exosomes are extracellular vesicles, which are involved in multiple stages of tumor progression. The role of macrophage-derived...
Mechanical properties and durability of slag granite geopolymer cement incorporated zirconium aluminum layered double hydroxide
Abstract This research developed an alkali-activated geopolymer (GP) cement using powdered granite waste (GW), blast furnace slag (BFS), and Zirconium aluminum Layered double hydroxide (Zr–A...
Predicting the insulating paper state of the power transformer based on XGBoost/LightGBM models
First-in-human dosimetry and safety evaluation of 68Ga-αMSH derivative for PET imaging of melanoma
Memory function in patients with opioid dependence treated with buprenorphine and methadone in comparison with healthy persons
Arch support insoles reduce fatigue of the lower extremity muscles in people with flatfoot during a walking task
Photobiomodulation promotes osteogenic differentiation of mesenchymal stem cells and increases P-Akt levels in vitro
Generative adversarial DacFormer network for MRI brain tumor segmentation
Design of machine learning-based controllers for speed control of PMSM drive
Abstract This study presents machine learning (ML)-based controllers for a surface permanent magnet synchronous motor (PMSM) drive system. The ML-based regression techniques like linear regr...
Knowledge, attitudes, and factors associated with vertical transmission of hepatitis B among pregnant women in Gurage Zone, Ethiopia
Retrospective analysis and IMRT replanning of a 3D-CRT murine dose painting study for preclinical oxygen-guided radiotherapy
Huaxian formula alleviates nickel oxide nanoparticle-induced pulmonary fibrosis via PI3K/AKT signaling
Abstract As a progressive fibrotic lung disorder with high mortality, pulmonary fibrosis (PF) suffers from inadequate treatment options. While the traditional Chinese medicine (TCM) formulat...
Polyoxyethylene and polypropylene emulsification enhances retinol palmitate efficacy in corneal wound healing
LZTS2 methylation as a potential diagnostic and prognostic marker in LIHC and STAD: Evidence from bioinformatics and in vitro analyses
Micromagnetic simulations with periodic strayfield calculation of soft magnetic composite-materials
Abstract This work provides a complete numeric framework, with which soft magnetic composite materials can be numerically analyzed through a combination of two distinct numerical met...
Improved CKD classification based on explainable artificial intelligence with extra trees and BBFS
Abstract Chronic kidney disease is a persistent ailment marked by the gradual decline of kidney function. Its classification primarily relies on the estimated glomerular filtration rate and...
Preserved circadian variation in cortisol and androgens during a ski traverse of Antarctica in summer
Abstract Antarctic expeditions present extreme physiological challenges due to cold temperatures, high physical exertion, and 24-hour daylight. This observational study evaluated endocrine a...