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Exploration of the shared diagnostic genes and molecular mechanism between obesity and atherosclerosis via bioinformatic analysis
Choroidal thickness under pilocarpine versus cyclopentolate
Intermittent enteral nutrition shortens the time to achieve nutritional goals in critically ill patients
p-Type BiVO<sub>4</sub> for Solar O<sub>2</sub> Reduction to H<sub>2</sub>O<sub>2</sub>
Multi-faceted examination of a deepwater seamount reveals ecological patterns among coral and sponge communities in the equatorial Pacific
Abstract Spatial changes in benthic community structure have been observed across natural gradients in deep-sea ecosystems, but these patterns remain under-sampled on seamounts. Here, we identify the spatial composition and distribution of coral and sponge taxa on four sides of a single central Pacific equatorial “model” seamount within the US EEZ surrounding the Howland and Baker unit of the Pacific Islands Heritage Marine National Monument. This seamount rises from 5,000 + m to mesophotic depths of 196 m, and is influenced by the Equatorial Undercurrent. Four remotely operated vehicle (ROV) transects were completed, one on each flank of the seamount. Shallower than ~ 250 m, the mesophotic seafloor was composed of scoured carbonate pavement with sediment accumulation only found in rocky depressions. Waters below 500 m hosted communities predominantly composed of octocorals, however, several coral taxa showed seamount flank preference (higher abundance on one or more flanks than the others) even though strong vertical (depth) zonation of corals and sponges was observed on all flanks. Euplectellidae, Plexauridae and Chrysogorgia spp. corals each showed a distinct preference for flank. To help visualize the influence of current flow, oxygen, depth, and substrate type on the zonation of seamounts, we created an Alexander Von Humboldt-style infographic to illustrate the observed biodiversity patterns. Given the importance of seamounts to ocean biodiversity and productivity, this study is an early attempt at a holistic visualization of seamount biology that can advance new hypotheses about seamount ecology.
A comparative study of polydopamine vs. glass ionomer cement for adhesion mechanisms on enamel and dentin using SEM and shear bond strength evaluation
Toward Sustainable Polydienes
Automatic detection and prediction of COVID-19 in cough audio signals using coronavirus herd immunity optimizer algorithm
Molecular Strain Accelerates Electron Transfer for Enhanced Oxygen Reduction
Research on the impact of mutual elderly care on the physical and mental health of rural elderly in China
Error mitigation in brainbox quantum autoencoders
Abstract Quantum hardware faces noise challenges that disrupt multiqubit entangled states. Quantum autoencoder circuits with a single qubit bottleneck have demonstrated the capability to correct errors in noisy entangled states. By introducing slightly more complex structures in the bottleneck, referred to as brainboxes, the denoising process can occure more quickly and efficiently in the presence of stronger noise channels. Selecting the most suitable brainbox for the bottleneck involves a trade-off between the intensity of noise on the hardware and training complexity. Finally, by analysing the Rényi entropy flow throughout the networks, we demonstrate that the localization of entanglement plays a central role in denoising through learning.
Researching on insulator defect recognition based on context cluster CenterNet++
Time delay effects on collective resonant behaviors in two coupled fractional oscillators with mass fluctuations
MicroRNA-32-5p promotes the proliferation and metastasis of gastric cancer cells
Biochemical failure-free survival of 18F-rhPSMA-7 and 18F-flotufolastat PET-guided salvage radiotherapy for patients with recurrent prostate cancer
Abstract Prostate-specific membrane antigen (PSMA)-targeted positron emission tomography (PET) has improved localization of prostate cancer (PC) lesions in biochemical recurrence (BCR) for salvage radiotherapy (SRT). We conducted a retrospective review of patients undergoing 18F-rhPSMA-7 or 18F-flotufolastat (18F-rhPSMA-7.3)-PET-guided SRT compared with conventional-SRT (C-SRT) without PET. We evaluated biochemical failure-free survival (bFS) and overall rates of bFS in 110 evaluable patients with recurrent PC after radical prostatectomy who received SRT. 82 patients received 18F-rhPSMA-7/18F-flotufolastat-PET-guided SRT and 28 received C-SRT. Median bFS for patients with 18F-rhPSMA-7/18F-flotufolastat-PET-guided SRT was not reached while median bFS was 45.6 months for patients with C-SRT (p = 0.101). %bFS were 95% (52/55) vs 87% (20/23), 90% (27/30) vs 75% (15/20), 89% (16/18) vs 68% (13/19) and 100% (3/3) vs 57% (8/14) for PET-guided vs C-SRT at 12, 24, 36, and 48 months, respectively. Among patients treated in the prostate bed only, median bFS was not reached for PSMA-PET-guided SRT (n = 52) vs 55.1 months in the C-SRT group (n = 25; p = 0.063). %bFS was greater for PSMA-PET-guided SRT than C-SRT at all evaluated timepoints. 18F-rhPSMA-7/18F-flotufolastat-guided SRT yielded favorable disease outcomes. Although statistical significance was not reached, likely due to the limited sample size in this preliminary analysis, our data illustrate potential for 18F-flotufolastat-PET-guided SRT.
Acoustic features of instrumental movie soundtracks elicit distinct and mostly non-overlapping extra-musical meanings in the mind of the listener
Tattooed human in vitro skin model for testing the biocompatibility of tattoo inks and healing progression after tattooing
Abstract Tattoos are widespread in the population. Tattoo inks, which contain a variety of ingredients among them hazardous compounds such as polyaromatic hydrocarbons, heavy metals and nanoparticles and that are made for injection into the skin, are not dermatologically tested. New testing systems for evaluation of biocompatibility of tattoo inks as composite products and the tattooing process itself are needed. This paper describes an in vitro 3D human skin model that was tattooed with black and red ink. Biocompatibility including analysis of cytotoxicity, cytokine release, and gene expression patterns of proinflammatory cytokines, proliferation markers, growth factors and structural components was investigated over a period of 7 days. Tattooing of the 3D skin model resulted in a strong inflammatory reaction comparable to in vivo observations that subsided 4 days after treatment. The subsequent healing phase was detectable in the gene expression patterns. Tattooing with two different tattoo inks resulted in distinguishable inflammatory reactions. The described 3D skin model is a useful tool for evaluation of the biocompatibility of tattoo inks and the tattooing process itself and for characterizing the healing process after tattooing.