Browse Articles

Abstract P1092: Preclinical Heart Failure Risk of Metabolically Healthy Overweight/Obese Adults in Hispanic/Latino Adults.

Intro: People with obesity who are metabolically healthy (MHO) have lower CVD and HF incidence compared to those with obesity and unhealthy metabolic risk factors (MOU), but higher risk than those with normal weight and metabolic healthy profiles (MHNW). However, it is unclear whether there are differences in left ventricle (LV) cardiovascular functioning/structure associated with early-stage HF (i.e., preclinical HF) risk among various metabolic health-body mass phenotypes within the Hispanic/Latino population. Therefore, the current study assessed preclinical HF risk in persons classified as Metabolically Healthy Overweight/Obese (MH-OW/OB) compared with MUO and MHNW, who were enrolled in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) and ancillary Echocardiographic Study of Latinos (ECHO-SOL). Methods: Data were derived from the HCHS/SOL&ECHO-SOL visit 2 ( n = 2082, M age = 54.5 years old, 51.2% women). Metabolic health was defined as having none of the following: elevated fasting glucose, triglycerides, blood pressure, insulin resistance, low HDL cholesterol and or use of medication for any of the elevated criteria (e.g., hypertension medication). Body Mass was assessed via BMI categories. Preclinical HF was defined as evidence of LV diastolic/systolic dysfunction and or LV hypertrophy measured via echocardiography. Weighted logistic regression assessed preclinical HF risk between MH-OW/OB vs MUO, and MH-OW/OB vs MHNW while controlling age, sex, field center, heritage, years living in US, and time since last visit (years between visit 1 and visit 2). Study design features were incorporated in planned logistic regression analyses. Results: Of the population, 329.1 were MH-OW/OB, 1088.1 were MUO, and 154.1 were MHNW (weighted counts). Weighted logistic regression analyses indicated that MH-OW/OB had lower risk of preclinical HF compared with MUO persons [Odds Ratio (OR): 0.25, 95% CI: 0.12-0.54]. Notably, MH-OW/OB persons were not significantly different in preclinical HF risk compared with MHNW persons [OR: 1.90, 95% CI: 0.58-6.22]. Conclusion: Results suggest that the MH-OW/OB classification may not confer added risk of preclinical HF compared to MHNW. However, findings indicate that MH-OW/OB has lower preclinical HF risk compared with MUO. Additional research is needed to determine if changes in cardiac structure/function are linked with adipocyte physiology that may underlie HF pathophysiology within the Hispanic/Latino population.

Correction for Manik et al., Structural basis for TIR domain–mediated innate immune signaling by Toll-like receptor adaptors TRIF and TRAM

Magnetic and mechanical hardening of nano-lamellar magnets using thermo-magnetic fields

Abstract High-performance magnetic materials based on rare-earth intermetallic compounds are critical for energy conversion technologies. However, the high cost and supply risks of rare-earth elements necessitate the development of affordable alternatives. Another challenge lies in the inherent brittleness of current magnets, which limits their applications for high dynamic mechanical loading conditions during service and complex shape design during manufacturing towards high efficiency and sustainability. Here, we propose a strategy to simultaneously enhance the magnetic and mechanical performance of a rare-earth-free multicomponent magnet. We achieve this by introducing nano-lamellar structures with high shape anisotropy into a cobalt–iron–nickel–aluminum material system through eutectoid decomposition under externally applied thermo-magnetic fields. Compared to the conventional thermally activated processing, the thermo-magnetic field accelerates phase decomposition kinetics, producing finer lamellae spacings and smaller eutectoid colonies. The well-tailored size, density, interface, and chemistry of the nano-lamellae enhance their pinning effect against the motion of both magnetic domain walls and dislocations, resulting in concurrent gains in coercivity and mechanical strength. Our work demonstrates a rational pathway to designing multifunctional rare-earth-free magnets for energy conversion devices such as high-speed motors and generators operating under harsh service conditions.

Abstract P1148: Coping with stressors: Does it predict health behaviors over more than a decade?

Objective: Emerging research suggests the use of certain strategies to cope with stressors relate to disease and mortality risk, and lifestyle habits may be underlying mechanisms. Studies show psychological symptoms (e.g., anxiety) and states (e.g., happiness) predict the likelihood of adopting an integrated lifestyle that encompasses key health-related behaviors, like smoking. Yet, whether psychological processes , including stress-related coping, influence the adoption of a healthy lifestyle is unknown. We investigated whether coping strategies typically deemed adaptive (e.g., seeking emotional support) and maladaptive (e.g., denial) relate to sustaining a healthy lifestyle over a 16-year follow-up. We also explored whether variability in use of these strategies, reflecting attempts to find the best strategy for a given stressor, subsequently relates to lifestyle. Methods: Women (N=46,067) from the Nurses’ Health Study II reported their use of eight coping strategies in 2001, from which we also derived coping variability levels (lower, moderate, greater). Health behaviors (e.g., physical activity, smoking, sleep) self-reported every four years from baseline until 2017, were combined into a lifestyle score. Generalized estimating equations, controlling for baseline demographics and health status, were performed. Results: Most adaptive strategies and greater variability levels were associated with higher likelihood of sustaining a healthy lifestyle (e.g., Active Coping, Relative Risk [RR]=1.09, 95% Confidence Interval [CI]=1.08-1.10), with the reverse evident with maladaptive strategies (e.g., Behavioral Disengagement, RR=0.93, CI=0.92-0.94), but some unexpected results also emerged. Conclusions: Findings highlight the importance of going beyond the usual (mal)adaptive categorization of coping strategies when investigating their predictive value with behavioral outcomes.

Abstract P1124: Investments in Programming by Depts. of Recreation and Parks is Associated with Reductions in Cardiovascular Disease and Other Health Outcomes

Introduction: Parks and park programming have been associated with more physical activity (PA), yet investments in parks are low. For the largest 100 US cities, the average spending for parks and recreation in 2022 was $126 per capita, with an average of $30 per capita devoted to programming. In contrast, the spending for health care in 2022 was $13,493 per capita. Physical inactivity accounts 11% of health care costs, and PA is strongly associated with better health and lower rates of cardiovascular disease. The goal of this study was to assess whether greater investments in parks and recreation will have a positive health benefit. Hypothesis: Spending on parks, programming and maintenance may be associated with better health outcomes, including lower cardiovascular disease (CV), hypertension (HTN) and Type 2 diabetes (T2DM). Methods: We tested the association between per capita spending by Depts. of Parks and Recreation and health outcomes among local residents who receive healthcare from Kaiser Permanente, which serves >20% of the Southern California (SoCal) population. Data consisted of 2022 per capita spending on park maintenance and programming collected by Trust for Public Land and 2022-2023 electronic health records from 732,504 adults in 10 SoCal cities. We calculated the risk ratio for CV, HTN and T2DM using Poisson model with robust variance estimator controlling for body mass index (BMI), population density, neighborhood deprivation index (NDI), age, gender, and race/ethnicity. Results: Of the 732,504 adults in 10 SoCal cities, 48,042 had CV conditions, 205,462 had HTN, 115,758 had Type2 DM. We found that for every $30 per capita per city spent on programming there were 8.9% fewer CV diagnoses (e.g. MI, CHF, atherosclerosis, cardiomyopathy, angina, etc.), 3.9% fewer diagnoses of HTN and 3.8% fewer T2DM cases (p<.0001 for all). Investments in park maintenance were not associated with CV outcomes but were associated with 1.3% lower T2DM and 1.8% lower HTN rates (p <.0001 for both). Conclusions. Programming has a stronger relationship than park maintenance with health outcomes, probably because it is the programming (sports, exercise classes, 5K walks and runs) that more strongly attracts park visitors and supports PA. While this is a cross-sectional study verifying the relationships between investments in park programming, park maintenance and health, a longitudinal study is needed to prove the health benefits of park programming and events.

Abstract 070: The Risk of Arrhythmias and Sudden Cardiac Arrest Associated with Methamphetamine, Cocaine, Opiate, and Cannabis Use: An Analysis of a Large Healthcare Claims Database

Introduction: Arrhythmogenic risks associated with substance use are poorly understood; existing studies are limited in scope or conducted in select populations. We conducted a longitudinal analysis to quantify the association of substance use with incident arrhythmias and sudden cardiac arrest (SCA) in a commercially insured population in the US. Methods: Using data from the MarketScan databases (2016-2022), we used ICD-10 codes to identify substances, outcomes, and covariates at each medical encounter. Substance users were matched with up to five non-substance users by age, sex, insurance enrollment date, and encounter date. Outcomes included atrial fibrillation (AF), ventricular tachycardia (VT), and a combined SCA/ventricular fibrillation (SCA/VF) outcome. We used Cox proportional hazards models to assess the association of each substance with each incident outcome, adjusting for demographics and comorbidities. Results: We matched 154,208 substance users to 697,869 non-users (mean age = 43 years; 46% female). Opiate and cannabis use were the most common (Table). During a mean follow-up of 2.1 years, there were 25,357 AF events, 6,351 VT events, and 2,095 SCA/VA events. After adjusting for potential confounders, the use of methamphetamines, cocaine, cannabis, and opiates was each associated with an increased risk of AF, with cannabis use having the highest risk of AF [HR: 1.84 (95% CI: 1.71, 1.98)] compared to matched non-users. All substances were associated with an increased risk of VT and SCA/VF, with cocaine use having the highest risk of SCA/VF [HR: 3.45 (95% CI: 2.77, 4.28)] compared to non-users. Conclusion: In this representative sample of commercially insured people, methamphetamine, cocaine, cannabis, and opiate use was each associated with a 1.5-3.5 times increased risk of developing arrhythmias. Given the ongoing drug crisis and increasing cannabis use in the US, understanding the association of substance use with arrhythmia risk will help better target arrhythmia prevention in these populations.

Major depressive disorder on a neuromorphic continuum

Abstract P2037: Impact of Extended Opportunistic Hypertension Screening on Cardiovascular Disease Outcomes: A Simulation Study

Background: Hypertension (HTN) is a major risk factor for cardiovascular diseases (CVD). The World Health Organization recommends opportunistic screening, defined as measuring blood pressure (BP) during routine healthcare visits even for unrelated reasons. However, implementation of this approach remains suboptimal, and the impact of extending such screening is unknown. Objective: To estimate the impact of extending opportunistic HTN screening in public healthcare facilities in Bangladesh from 20% to 80% of eligible adults on CVD outcomes. Methods: Using a two-stage modelling framework, we estimated the impact of extending opportunistic screening from 20% (current) to 80%(goal) among adults (age > 25) without HTN treatment. First, we simulated the intervention effect on systolic BP (SBP), using a microsimulation model. Next, we incorporated the SBP effect in a state-transition model to estimate the 10-year impact on incident CVD events and deaths, assuming SBP effects were maintained over 10 years. Key model inputs were derived from clinical trials, the 2018 WHO STEPS survey, and the 2019 Global Burden of Disease Study. Results: Extended screening was estimated to increase HTN treatment coverage and prevent incident CVD events in the model population ( Figure ). Extending opportunistic screening from 20% to 80% could increase the number of people screened from 149,925 to 599,685/million (Panel A), and an additional 15,417/million more persons will be diagnosed and started on treatment (an increase from 16,857 to 32,274/million). Over 10 years, the extended screening could avert ~1,900 incident CVD events and ~340 averted CVD deaths, per 1 million eligible population (Panel B). Conclusions: Extending opportunistic HTN screening with subsequent treatment could substantially reduce CVD burden among adults with untreated HTN in Bangladesh. Understanding the costs related to screening and treatment requires further investigation.

Abstract P3124: Risk Factors of Atrial Fibrillation, Heart Failure and Their Co-occurrence in Postmenopausal Women: A Womens’s Health Initiative Study

Introduction: Heart failure (HF) and atrial fibrillation/flutter (AF) often cooccur in older adults, the risk factors for which are understudied and was the objective herein. Method: This prospective cohort study included 31,171 post-menopausal women from the Women’s Health Initiative (WHI) with adjudicated HF merged with Medicare database for AF ascertainment during median follow-up of 17 years. Participants were categorized into 4 groups: no incident AF or HF (n=22,578), with incident AF (n=1,123), with incident HF (n=1,004), and with both incident AF-HF (n=6,466). Baseline exposures evaluated were age, race, obesity, alcohol consumption, smoking, education, income, companionship, physical activity, hypertension, hyperlipidemia, diabetes, and coronary artery disease (CAD). Exposures were compared using multinomial logistic regression model to assess odds ratios (OR) and 95% confidence intervals (CI) for each factor adjusting for the others. The jointly defined referent group was absence of the exposure and no HF or AF. Result: AF had an incidence proportion of 24.3%, HF 24%, and both AFHF was 20.7%, which is 3.55 times the expected co-incidence. Participants had a mean age of 63.2 (6.9) years at baseline. The odd of incident AF, incident HF and both incident AFHF was higher with older age [OR, 95% CI AF: 1.06 (1.06, 1.07); HF: 1.07 (1.07, 1.09); both AFHF: 1.12 (1.11, 1.13)], obesity [OR, 95% CI AF: 1.26 (1.18, 1.34); HF: 1.55 (1.34, 1.79); both AFHF: 1.72 (1.50, 1.97)], past/ current smoker [OR, 95% CI AF: 1.25 (1.12, 1.39); HF: 2.26 (1.81, 2.81); both AFHF: 1.77 (1.41, 2.24)], higher alcohol std drink/week [OR, 95% CI AF: 1.01 (1.01, 1.02); HF 1.01 (0.99, 1.02); both AFHF: 1.02 (1.01, 1.03)], CAD [OR, 95% CI AF: 1.23 (1.03, 1.47); HF: 2.25 (1.69, 2.99); both AFHF: 2.16 (1.63, 2.86)] and hypertension [OR, 95% CI AF: 1.19 (1.12, 1.27); HF: 1.44 (1.24, 1.67); both AFHF: 1.640 (1.42, 1.88)]. Diabetes was associated with incident HF [OR, 95% CI 2.53 (2.08, 3.08)] and both incident AF-HF [OR, 95% CI 2.03 (1.65, 2.50)] but not with AF alone. Conclusion: Incident AF, HF are common in older women with their co-incidence 3.55 times higher than expected suggesting a common underlying pathophysiology. Obesity, alcohol consumption, past/ current smoker, hypertension and CAD are major risk factors for AF, HF and their co-occurrence. These findings underscore the importance of targeted interventions to manage these modifiable risk factors to prevent both conditions.

Abstract P1170: Lifestyle interventions for prevention of cardiovascular disease among mothers of young children: a scoping review

Background: The prevalence of cardiovascular disease (CVD) risk factors is high and rising among younger women. Mothers of young children often exhibit poorer diets and lower physical activity levels than mothers of older children and women without children. CVD risk remains elevated well past the 1-year postpartum period for those with adverse pregnancy outcomes. Yet, little is known about interventions for CVD prevention among this group. Objective: To review and synthesize the available literature on lifestyle interventions for CVD prevention among mothers of young children (≤5 years) and highlight gaps to inform future research. Methods: We searched PubMed, Scopus, Web of Science, CINAHL, and EMBASE for peer-reviewed English-language articles published 2009-2023 on lifestyle interventions for CVD prevention in mothers with children 1-5 years. The rationale for this age range was because the care needs for this age group are distinct from those of infants but require a higher degree of hands-on caregiving compared to older children. The review was conducted following PRISMA-ScR guidelines, with articles screened by two independent reviewers, with a third reviewer available to resolve conflicts. Results: Of 1,405 studies, none exclusively recruited mothers with children 1-5 years. Six studies were eligible because reported mean child age was ≤5 years (Figure 1). Total sample size across studies was 1,614. Five were randomized controlled trials testing in-person (n=3) or digital (n=2) lifestyle interventions. Interventions included workshops with physical activity sessions (n=1), in-person physical/mental health education (n=3), video-based physical/mental health education with peer support groups (n=1), and a smartphone app (n=1). No interventions focused on sleep or tobacco use (Life’s Essential 8 components), or addressed social determinants, which are major drivers of health. Study follow-up ranged from 6-18 months. Outcome measures included self-reported diet, physical activity, perceived stress, and quality of life, and objective assessments of blood pressure, glucose, lipid levels, and weight. Five of 6 studies reported positive results at their primary time points. Conclusions: Effective strategies to improve CVD risk in mothers of young children have the potential to prevent CV events in later life. Our results highlight a significant gap in the literature on such interventions, underscoring the need for targeted research for this population.

Enantioselective synthesis of chiroplasmonic helicoidal nanoparticles by nanoconfinement in chiral dielectric shells

Abstract MP36: Food and Nutrition Insecurity Impacts Cardiovascular Risk Factors Among Latina Women

Introduction: Nutrition security is an emerging concept that expands upon the definition of food security – consistent access to sufficient quantity and quality of food – to include prevention, management, and treatment of disease. There is limited evidence on how nutrition security is related to heart health, specifically in populations disproportionately impacted by cardiovascular disease risk, such as Latina women. Hypothesis: Latina women experiencing food and/or nutrition insecurity will have poorer indicators of Life’s Essential 8 compared to those with food and/or nutrition security. Methods: Vida Sana y Completa is randomized controlled trial of a multi-component Food is Medicine (FIM) intervention for Latina women with obesity (BMI>30kg/m 2 ). This analysis uses survey data from baseline assessment (n=165). Food security status was assessed using the USDA 6-item screener and nutrition security status was assessed using the 4-item Nutrition Security Scale. Outcomes included vegetable and fruit intake, BMI, blood pressure (BP), and mental health. Within group differences by food and nutrition security status were performed using ANOVA with Fischer’s least significant difference and independent two-sample t-tests. Results: The majority (82%) reported food insecurity and approximately half (47%) reported nutrition insecurity. Women with very low or low food security consumed fewer vegetables compared to those with food security (1.7 vs. 2.1 vs. 3.0, respectively; p=0.02). Women with nutrition insecurity also consumed fewer servings of vegetables compared to participants with nutrition security (1.7 vs. 2.5; p=0.01). Systolic BP was higher among women with low food security, compared to participants with very low food security or participants with food security (p=0.01). Diastolic BP was higher for participants with low and very low food security compared to participants with food security (p=0.03). There was no difference in BP by nutrition security status. Participants with food and nutrition insecurity had more symptoms of depression and anxiety compared to participants with food and nutrition security(p<0.05). There were no differences in daily servings of fruit or BMI by food and/or nutrition security status. Conclusion: Latina women with food and/or nutrition insecurity are at increased risk for cardiovascular disease. FIM interventions may effectively address food and/or nutrition insecurity, as well as Life’s Essential 8, to improve heart health.

Abstract P3143: The Association of Psychosocial Factors with Diet Quality in a Puerto Rican Adults

Healthy dietary patterns are important for cardiometabolic health. Psychosocial factors are also associated with health outcomes, with studies suggesting that poor psychosocial health is associated with low diet quality. Few studies have examined these associations in adults living in Puerto Rico. This study examines the cross-sectional association of psychosocial factors (depression, loneliness, stress, and social support) with diet quality. This is a secondary analysis of a randomized pilot trial, the Puerto Rican Optimized Mediterranean-like Diet (PROMED), that examined the effect of a culturally appropriate Mediterranean-like diet on cardiometabolic health in a sample of adults with at least two cardiometabolic conditions living in Puerto Rico. Participants were randomized to an intervention or control group and completed 3 visits. Interviewer-administered questionnaires assessed perceived stress, depression, loneliness, and social support as well as a brief diet quality index. Responses were summarized into scores and examined as continuous variables. Diet quality score was log-transformed to aid interpretation of model coefficients. Mixed effects models were used to estimate the association of each psychosocial factor with diet quality. A backwards stepwise method was applied to assess the contribution of each psychosocial factor within a single model; likelihood ratio tests evaluated model fit. Multivariable models controlled for age, gender, education, marital status, and study group. Among 44 participants (94 observations, average 2 visits each), the mean age was 50.6 years (SD=9.5) and 80% were female (Table 1). Distribution of diet quality and psychosocial variables is shown in Figure 1. For every 1-unit increase in social support, diet quality increased by 0.35% (95% CI 0.02, 0.67), while every 1-unit increase in stress was associated with a 0.31% decrease in diet quality (95% CI -0.05, -0.56). Depression (-0.17%; 95% CI -0.35, 0.01) and loneliness (-1.34; 95% CI -2.78, 2.31) were also associated with decreases in diet quality, but these associations were not statistically significant (p>0.05). Backwards stepwise analysis identified stress as the main contributor to diet quality. Stress and social support are key factors affecting diet quality among adults living in Puerto Rico. Interventions aimed at improving diet and cardiometabolic health should consider how psychosocial factors impact dietary behaviors and overall health outcomes.

Abstract P1140: PREVENT 30-Year CVD Risk Associated With Greater Odds of Adverse Pregnancy Outcomes

Introduction: Poor pre-pregnancy cardiovascular health is associated with adverse pregnancy outcomes (APOs). We sought to investigate whether estimated 30-year CVD risk from the PREVENT equation similarly predicts APOs. Hypothesis: We hypothesized that higher 30-year CVD risk mid-pregnancy would be associated with greater risk of APOs, including preterm delivery and preeclampsia. Methods: Participants are from the Stress, Pregnancy, and Health (SPAH) study, conducted in Evanston, IL between 2018-2023. During the 2 nd trimester study visit, blood pressure was measured and participants provided a blood sample. Nuclear magnetic resonance was used to measure serum cholesterol and creatinine (used to estimate eGFR). Medication use, pre-gestational diabetes diagnosis, and APOs, including preterm delivery (<37 weeks gestation), early preterm delivery (<34 weeks) and preeclampsia, were abstracted from medical records. The PREVENT equation was used to estimate 30-year CVD risk based on 2 nd trimester measures. Logistic models were used to test associations between CVD risk in pregnancy and APOs, adjusted for race/ethnicity, as a marker of structural factors, socioeconomic position, based on household educational attainment and occupational prestige, and gestational age at the study visit. Results: SPAH included 605 participants, 524 of whom had complete data to estimate 30-year CVD risk from the 2 nd trimester study visit (mean gestational age at visit: 23.7 weeks, SD: 1.7). The mean age of participants was 33.3 years (SD: 5.5) and 18% identified as Black, 21% as Hispanic, 49% as White, and 12% as another group. The mean 30-year CVD risk during pregnancy was 7.6% (SD: 6.6), 11% delivered preterm, and 10% developed preeclampsia. In the adjusted model, a 1 SD increase in CVD risk was associated with 41% greater odds of preterm delivery (95% CI: 1.14, 1.74), 67% greater odds of early preterm delivery (95% CI: 1.27, 2.19), and 71% greater odds of developing preeclampsia (95% CI: 1.36, 2.14; Figure 1). Conclusions: Results suggest that a higher PREVENT 30-year estimated CVD risk in mid-pregnancy is associated with greater odds of delivering preterm and developing preeclampsia. These APOs are associated with long-term offspring CVD risk, also highlighting the intergenerational implications of PREVENT CVD risk estimates.

Galvanic leaching recycling of spent lithium-ion batteries via low entropy-increasing strategy

Abstract P1032: De novo lipogenesis is related to multiple cardiometabolic diseases in post-myocardial infarction patients of the Alpha Omega Cohort

Introduction: Hepatic de novo lipogenesis (DNL) is the biological process of fatty acids synthesis from non-lipid precursors of glycolysis. Elevated DNL has been implicated in metabolic dysregulation, potentially contributing to fatty liver disease (FLD), cardiovascular disease (CVD), and impaired kidney function. Little is known about DNL and cardiometabolic endpoints in patients with a history of a myocardial infarction (MI). Methods: We included 4305 patients from the Alpha Omega Cohort, aged 60-80 y, with an MI <10 y prior to enrollment. DNL was assessed at baseline (2002-2006) using the lipogenic index, for which we calculated the ratio of palmitic acid (C16:0) and linoleic acid (C18:2n-6) in plasma cholesterol esters. Prevalent FLD was defined as the upper sex-specific tertile of the Fatty Liver Index (FLI), based on BMI, waist circumference, serum triglycerides and gamma-glutamyl transferase. The estimated glomerular filtration rate (eGFR; CKD-EPI equation) was monitored from baseline through 2009 (median follow-up: 3.4 y). CVD mortality risk was monitored through 2022 (median follow-up: 14.5 y). Prevalence ratios (PR) for FLD and hazard ratios (HR) with 95% confidence intervals (CI) for CVD mortality in quintiles of the lipogenic index (Q1, reference) were obtained from Cox models. Betas (95%CI) for annual eGFR change were obtained from linear regression models. Multivariable models included demographics, anthropometrics, lifestyle, and cardiovascular risk factors. Results: Patients (79% male) had a mean (SD) age of 69 (6) y and a BMI of 27.7 (3.8) kg/m 2 . Of the cohort, 24% were obese, 17% were smokers, and 86% were on lipid lowering medication. Baseline FLI was 65 (23) and eGFR was 81 (21) mL/min/1.73m 2 , with 15% having eGFR <60. The annual eGFR change was -1.7 (3.8) during short-term follow-up. The number of deaths was 305 (138 from CVD) during short-term follow-up and 2827 (1096 from CVD) during long-term follow-up. The lipogenic index (Q5 vs Q1) was associated with a higher FLD prevalence (PR: 1.67; 95%CI: 1.40 to 2.00), more annual kidney function decline (beta: -0.76; -1.32 to -0.20), and an increased CVD mortality risk (short-term HR: 1.83; 1.06 to 3.15; long-term HR: 1.38; 1.14 to 1.68). Conclusion: Elevated DNL in post-MI patients is associated with FLD, kidney function decline, and CVD mortality risk. An abnormal hepatic fatty acid synthesis may represent a common pathophysiological pathway in cardiometabolic diseases.

Abstract P3177: Longitudinal Recovery after Intracerebral Hemorrhage: Insights from BASIC Study

Background: Intracerebral hemorrhage (ICH) is a severe stroke type with high mortality, significantly affecting survivors' quality of life (QOL) through functional, cognitive, and psychosocial impairments. Objective: To investigate longitudinal trajectories of functional, neurological, cognitive, and QOL outcomes following ICH, utilizing data from the Brain Attack Surveillance in Corpus Christi (BASIC) project (2014-2019). Methods: Baseline demographic and clinical characteristics were collected. Neurological, functional, cognitive, and QOL outcomes were measured using the National Institutes of Health Stroke Scale (NIHSS), Activities of Daily Living (ADL/IADL), Modified Mini-Mental State Exam (3-MSE), and Stroke-Specific QOL (SS-QOL) scale at 3-, 6-, and 12-months post-stroke. Linear regression models with generalized estimating equations assessed changes over time, adjusting for covariates including age, sex, race/ethnicity, education, pre-stroke status, and comorbidities. Inverse probability weighting and multiple imputation were applied. Results: Analysis included 328 first-ever ICH patients, with 117 completing at least one follow-up. Baseline demographics: 63.1% Mexican American, 55.5% male, mean age 68.9 years. One-year mortality was 43.3%. Among the 117, functional outcomes improved significantly: from 2.48 (SD=1.00) at 3 months to 2.14 (SD=0.93) at 12 months (adjusted difference: -0.33; 95% CI: -0.49 to -0.18; p<0.001). NIHSS scores reduced from 3.45 (SD=4.38) to 2.6 (SD=5.14) (adjusted change: -20%; 95% CI: -30% to -9%; p<0.001). Cognitive scores increased from 79.2 (SD=15.2) to 82.3 (SD=13.0) (adjusted difference: 5.13; 95% CI: 1.56 to 8.71; p=0.005). QOL improved from 3.16 (SD=1.09) to 3.45 (SD=1.01) (adjusted difference: 0.30; 95% CI: 0.16 to 0.44; p<0.001). Conclusion: Despite a high mortality rate of ICH, survivors demonstrated significant improvements in all outcomes over the first year. For most outcomes, the most notable gains occurred in the initial 3 to 6 months, though functional outcomes and quality of life showed continued improvement from 6 to 12 months. These findings emphasize the potential for recovery and the importance of early and intensive rehabilitation efforts to optimize long-term outcomes for ICH patients.

Abstract P3115: Summary Measure of Social Determinants of Health/Health Equity and Obesity among Mississippi Adults

Background: In 2022, about 752,180 Mississippi adults were classified as obese. Social determinants of health (SDOH) contribute to obesity and associated disparities. We examined the association between a summary measure of SDOH and obesity among Mississippi adults. Methods: Using the SDOH and Health Equity (SDOH/HE) Module data from 3,994 respondents in the 2022 Mississippi Behavioral Risk Factor Surveillance System survey, we conducted multivariable logistic regression models to examine the association between a SDOH/HE summary measure and obesity. Results: Mississippians experiencing two (AOR, 1.68, 95% CI 1.19-2.36) of SDOH/HE risk factors had higher odds of being obese compared to those experiencing no SDOH/HE risk factors. Conclusions: Mississippi adults with two SDOH/HE risk factors had significantly higher odds of obesity than those with no SDOH/HE risk factors. Findings highlight the importance of addressing multiple SDOH/HE factors in obesity prevalence among Mississippi adults experiencing two SDOH/HE risk factors.

Improved radicchio seedling growth under CsPbI3 perovskite rooftop in a laboratory-scale greenhouse for Agrivoltaics application

Abstract P2145: Low Physical Activity is Associated with Hypertensive Disorders of Pregnancy in Californian Women with Overweight or Obesity

Introduction: Hypertensive disorders of pregnancy (HDPs) are rising in the United States, leading to increased maternal mortality, future pregnancy complications, and cardiovascular disease (CVD) risk factors like hypertension and diabetes. Studies suggest that HDPs have different etiologies than non-pregnancy hypertensive disorders, and it is unclear whether behavioral and lifestyle risk factors for CVD in general are similar for HDPs. Hypothesis: We hypothesized that women with lower levels of physical activity early in pregnancy would have a higher risk for HDPs. Methods: We analyzed data from pregnant women in California with overweight or obesity enrolled in the Goals for Reaching Optimal Wellness (GROWell) trial. A logistic regression model was used to assess the association between physical activity in early pregnancy (10-16 weeks) and later HDPs (gestational or chronic hypertension, or preeclampsia) while controlling for diet, depression, anxiety, sleep, and factors such as age, parity, BMI, maternal education, and race. Physical activity was measured in metabolic equivalents using the pregnancy physical activity (PPAQ) survey. Results: Among 453 participants, 38 (~8.4%) experienced HDPs. Average age for participants was 33.6 ± 4.1 years, 59% identified as a member of a historically minoritized group. Lower physical activity levels were associated with an increased risk of developing HDPs later in pregnancy (OR = 0.98, p = 0.003), after controlling for diet quality, sleep, mood, and demographics. The association between lower PPAQ scores and HDPs was significant for light-intensity (OR = 0.98, p = 0.04), moderate-intensity (OR = 0.97, p = 0.008), and household/caregiving activities (OR = 0.98, p = 0.006). Conclusion: Low physical activity levels in early pregnancy may contribute to the risk of developing HDPs. Importantly, general activity and light to moderate intensity physical activity demonstrated benefit, suggesting that even small increases in activity may be protective. Future research with larger samples should explore the role of different kinds of activity in the prevention of HDPs, especially for women with overweight or obesity, where physical inactivity may compound the risk for adverse pregnancy outcomes.