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Magnetic Hysteresis in a Dysprosium Bis(amide) Complex
Transition State Analysis of SAMHD1 from Primary <sup>18</sup>O, <sup>33</sup>P, and Solvent Kinetic Isotope Effects
Structural Influence of the Chemical Fueling System on a Catalysis-Driven Rotary Molecular Motor
Industrialization of Covalent Organic Frameworks
Photothermal Cavitation-Driven Micromotor to Penetrate Cell Membrane
Probing the Dynamics of Yersinia Adhesin A (YadA) in Outer Membranes Hints at Requirements for β-Barrel Membrane Insertion
Rational Construction of Layered Two-Dimensional Conjugated Metal–Organic Frameworks with Room-Temperature Quantum Coherence
Ion transport in helical-helical polypeptide polymerized ionic liquid block copolymers
Functional Design of Peptide Materials Based on Supramolecular Cohesion
Structure and function relationships of mucociliary clearance in human and rat airways
Electric Field-Driven Long-Range Order and Enhanced Polarization Switching in High-Dipole Ionic Liquids
β-catenin-driven endomesoderm specification is a Bilateria-specific novelty
Abstract Endomesoderm specification by a maternal β-catenin signal and body axis patterning by interpreting a gradient of zygotic Wnt/β-catenin signalling was suggested to predate the split between Bilateria and their sister clade Cnidaria. However, in Cnidaria, the roles of β-catenin signalling in these processes have not been demonstrated directly. Here, by tagging the endogenous β-catenin in the cnidarian Nematostella vectensis, we confirm that its oral-aboral axis is indeed patterned by a gradient of β-catenin signalling. Strikingly, we show that, in contrast to bilaterians, Nematostella endomesoderm specification is repressed by β-catenin and takes place in the maternal nuclear β-catenin-negative part of the embryo. This completely changes the accepted paradigm and suggests that β-catenin-dependent endomesoderm specification was a bilaterian innovation linking endomesoderm specification to the subsequent posterior-anterior patterning.
Photodriven Ammonia Synthesis from N<sub>2</sub> and H<sub>2</sub>: Recycling of a Molecular Molybdenum Nitride
Upcycling waste commodity polymers into high-performance polyarylate materials with direct utilization of capping agent impurities
Favoring the Originally Unfavored Oxygen for Enhancing Nitrogen-to-Nitrate Electroconversion
A globular protein exhibits rare phase behavior and forms chemically regulated orthogonal condensates in cells
An mRNA Display Approach for Covalent Targeting of a <i>Staphylococcus aureus</i> Virulence Factor
Photo-induced ring-maintaining hydrosilylation of unactivated alkenes with hydrosilacyclobutanes
Abstract Increasing attention has been paid to silacyclobutanes because of their wide application in ring opening and ring extension reactions. However, the synthesis of functionalized silacyclobutanes remains an unmet challenge because of the limited functional group tolerance of the reactions with organometallic reagents and chlorosilacyclobutanes. Herein, we report a conceptually different solution to this end through a visible-light-induced metal-free hydrosilylation of unactivated alkenes with hydrosilacyclobutanes. A wide range of unactivated alkenes with diverse functional groups including the base-sensitive acid, alcohol and ketones participated in this reaction smoothly. In particular, the first hydrosilylation reaction of alkenes with dihydrosilacyclobutane provides a facile access to various functionalized alkyl monohydrosilacyclobutanes. Unsymmetrical dialkyl silacyclobutanes have also been synthesized through consecutive hydrosilylation with dihydrosilacyclobutane in one pot. The mechanism study reveals that the Lewis basic solvent could promote the generation of strained silyl radicals by direct light irradiation without a redox-active photocatalyst and the thiol catalyst plays an important role in accelerating the reaction.