Browse Articles

Reducing the road freight emissions through integrated strategy in the port cities

Real-time multi-class threat detection and adaptive deception in Kubernetes environments

Abstract Kubernetes has emerged as the backbone of modern cloud-native environments, enabling efficient orchestration of containerized applications. However, its dynamic nature exposes it to sophisticated cyber threats, including privilege escalation, reconnaissance, and denial-of-service attacks. This paper presents a novel framework that combines real-time multi-class threat detection with adaptive deception to enhance Kubernetes security. The framework integrates KServe for scalable machine learning-based threat classification, CICFlowMeter for feature extraction, and KubeDeceive for dynamic deployment of decoys, all governed by the MAPE-K loop for continuous adaptation. Evaluations demonstrate high detection accuracy (up to 91%), efficient resource utilization, and effective attacker engagement, with decoy success rates reaching 93%. The results underscore the framework’s ability to proactively mitigate threats, maintain system resilience, and provide actionable intelligence. This unified approach represents a scalable and adaptable defense mechanism for Kubernetes environments, catering to the needs of dynamic and resource-intensive cloud infrastructures.

Single-cell and chromatin accessibility profiling reveals regulatory programs of pathogenic Th2 cells in allergic asthma

Abstract Lung pathogenic T helper type 2 (pTh2) cells are important in mediating allergic asthma, but fundamental questions remain regarding their heterogeneity and epigenetic regulation. Here we investigate immune regulation in allergic asthma by single-cell RNA sequencing in mice challenged with house dust mite, in the presence and absence of histone deacetylase 1 (HDAC1) function. Our analyses indicate two distinct highly proinflammatory subsets of lung pTh2 cells and pinpoint thymic stromal lymphopoietin (TSLP) and Tumour Necrosis Factor Receptor Superfamily (TNFRSF) members as important drivers to generate pTh2 cells in vitro. Using our in vitro model, we uncover how signalling via TSLP and a TNFRSF member shapes chromatin accessibility at the type 2 cytokine gene loci by modulating HDAC1 repressive function. In summary, we have generated insights into pTh2 cell biology and establish an in vitro model for investigating pTh2 cells that proves useful for discovering molecular mechanisms involved in pTh2-mediated allergic asthma.

Theoretical model and experimental verification of seepage-transition-spontaneous imbibition in water migration of water-injected coal

Optically tunable catalytic cancer therapy using enzyme-like chiral plasmonic nanoparticles

Simulating online and offline tasks using hybrid cheetah optimization algorithm for patients affected by neurodegenerative diseases

Abstract Brain-Computer Interface (BCI) is a versatile technique to offer better communication system for people affected by the locked-in syndrome (LIS).In the current decade, there has been a growing demand for improved care and services for individuals with neurodegenerative diseases. To address this barrier, the current work is designed with four states of BCI for paralyzed persons using Welch Power Spectral Density (W-PSD). The features extracted from the signals were trained with a hybrid Feed Forward Neural Network Cheetah Optimization Algorithm (FFNNCOA) in both offline and online modes. Totally, eighteen subjects were involved in this study. The study proved that the offline analysis phase outperformed than the online phase in the real-time. The experiment was achieved the accuracies of 95.56% and 93.88% for men and female respectively. Furthermore, the study confirms that the subject’s performance in the offline can manage the task more easily than in online mode.

Milestone in predicting core plasma turbulence: successful multi-channel validation of the gyrokinetic code GENE

Abstract On the basis of several recent breakthroughs in fusion research, many activities have been launched around the world to develop fusion power plants on the fastest possible time scale. In this context, high-fidelity simulations of the plasma behavior on large supercomputers provide one of the main pathways to accelerating progress by guiding crucial design decisions. When it comes to determining the energy confinement time of a magnetic confinement fusion device, which is a key quantity of interest, gyrokinetic turbulence simulations are considered the approach of choice – but the question, whether they are really able to reliably predict the plasma behavior is still open. The present study addresses this important issue by means of careful comparisons between state-of-the-art gyrokinetic turbulence simulations with the GENE code and experimental observations in the ASDEX Upgrade tokamak for an unprecedented number of simultaneous plasma observables.

An epidemiological investigation of oral and maxillofacial anomalies in newborns and their relation to parental health in the Ha’il Region, Saudi Arabia

An innovative approach based on health surveillance for the prevention and early detection of cardiovascular diseases in a large cohort of healthcare workers

A large language model for advanced power dispatch

Pilot study results from the assertive community treatment transitional intervention program in Switzerland

Abstract Often, after an inpatient stay, early readmission occurs, which is detrimental to the patient. University Psychiatric Clinics Basel developed a 3-month transitional intervention program to bridge inpatient and community treatment by supporting people after their discharge from the psychiatric hospital. In line with international guidelines, this transitional intervention was delivered as assertive community treatment in the homes of people who wished to participate. Data from the 3-year pilot project starting in 2019 have been collected to analyze the success of its implementation and treatment effectiveness in reducing follow-up inpatient treatment days when comparing people choosing to participate in the transitional program and receiving treatment (n cases  = 456) versus people declining participation (n cases  = 104). Results indicate that within 3 years, a multidisciplinary team could be assembled that was able to work with a caseload of up to 66 persons per month. Receipt of treatment was descriptively associated with lower numbers of inpatient treatment days, stays, and involuntary admissions 6 months after discharge; however, this difference did not reach statistical significance. Program participants further reported very high levels of satisfaction. These findings provide an outlook on the program’s feasibility and potential benefits.

Study on the compressive performance and numerical simulation of fiber-reinforced geopolymer stabilized aeolian sand subgrade materials

Development of moringa seed powder-modified slag geopolymers for enhanced mechanical properties and effective dye removal

Abstract Crystal violet (CV), a widely used dye in paints and textiles, poses a significant environmental threat due to its non-biodegradable nature. A modified slag-based geopolymer has been developed to address this issue by incorporating raw moringa seed powder (MSP), an agricultural waste. The geopolymers (SM1, SM2, and SM3) were created by adding different percentages of MSP (0.2%, 0.6%, and 1% by weight) to ground granulated blast furnace slag (GGBFS), using sodium silicate and 10 M sodium hydroxide as alkali activators. This combination enhances the geopolymer’s mechanical and adsorbent properties, making it more effective for CV removal. The geopolymer composites were analyzed using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). Their mechanical properties were evaluated by conducting compressive strength and total porosity tests. Pore structure analysis was performed using nitrogen adsorption and desorption techniques, and the point of zero charges was determined. Additionally, batch experiments were carried out to investigate the adsorption of CV dye, employing two isotherm models and kinetic models for analysis. The SM1 mix, which is a modified slag-based geopolymer containing 0.2% MSP, exhibited the highest compressive strength at 73 MPa after 180 days, representing a 25.8% improvement compared to the control mix (100% slag). Furthermore, modified geopolymer mixes showed greater adsorption activity toward crystal violet compared to the control mix, with the SM3 mix achieving an adsorption capacity of up to 322.58 mg/g. The study demonstrates that adding MSP to slag-based geopolymer enhances mechanical strength and adsorption capacity. This indicates a positive impact on the composite’s surface properties and highlights the environmental benefits of utilizing industrial and agricultural waste in wastewater treatment.

The comparative efficacy of L-glutamine, celecoxib, and glucosamine sulfate in osteoarthritis management

LncRNA TERRA in hybrid with DNA is a relevant biomarker for monitoring patients with meningioma

Genetic instability in HSPC subpopulations of umbilical cord blood from patients with childhood acute lymphoblastic leukemia

Abstract Preleukemic stem cells (PSC) containing preleukemic fusion genes (PFG) arise prenatally and represent the initial stage of acute lymphoblastic leukemia (ALL) development. Despite widespread efforts, the cell of origin of PFG is still unclear. For the first time, in order to identify the immunophenotype of the PSCs, different subpopulations of hematopoietic stem and progenitor cells (HSPC) of umbilical cord blood (UCB) from ALL pediatric patients and control healthy children were sorted and analyzed for the presence of diagnostically-relevant PFGs by fluorescent in situ hybridization (FISH). Representative FISH results were confirmed by RT-qPCR and validated by sequencing of the products. Not only did we identify likely subpopulations of TEL/AML1+ PSC to be CD34+ CD38+ and CD34+ CD38− cells, but we also found markedly increased instability of often associated with ALL genes in UCB HSPC subpopulations of ALL pediatric patients. Our data show that CD34+ CD38+ as well as CD34+ CD38− cells are prone to genetic instability and most likely represent the target for malignant transformation in the development of ALL. Overall, together with confirming the prenatal origin of PFGs, this study provides further insight into the preleukemic stage of ALL and shows that ALL is a potentially screen able disease.

Association between percent body fat and the risk of prediabetes among Chinese adults: a 5-years longitudinal cohort study

Pacing in ultra-marathon running: the Western States 100-mile endurance run 2006–2023

Empagliflozin demonstrates neuroprotective and cardioprotective effects by reducing ischemia/reperfusion damage in rat models of ischemic stroke and myocardial infarction

Timing of human rhythmic jumping with vertical floor vibrations tends towards mechanically efficient solutions

Abstract Jumping on vibrating platforms is described not only by the frequency of jumping (FoJ) but also by the timing of key events in a cycle of jumping relative to vibrations. This study aimed to capture timing and efficiency-related adaptations during jumping on vertically vibrating platforms. Whole body kinematic and kinetic data were collected as ten participants jumped on a sinusoidally vibrating platform of 2.0, 2.4 and 2.8 Hz at 2 m/s2. FoJ matched platform frequency, and audio cues were provided to time the jump landing at four positions relative to the platform position: reference position on its way down, lowest position, reference position on its way up, and highest position. FoJ, jump timing, impact factor, contact ratio, mechanical work and leg stiffness were calculated for each jump cycle. Results confirmed that the impact factor, contact ratio, mechanical work, and leg stiffness are timing-dependent. Results also showed that despite being cued, participants adjusted their timing to take off from a higher platform position during its downward motion and land at a lower position during the upward motion while maintaining FoJ. Importantly, participants tended towards efficiency by employing jump timings related to lower energy input, appropriate contact ratio and lower forces. This study provides evidence of jump timing behaviour relative to platform motion being dominated by the efficiency of jumping. Practically, it may be crucial to consider this aspect when estimating human-induced loads on lively assembly structures.