Browse Articles

Amblyopic binocular imbalance quantified by the dichoptic contrast ordering test and dichoptic letters test

Mutational signature analysis predicts bacterial hypermutation and multidrug resistance

Influence of rock heterogeneity on the correlation between uniaxial compressive strength and Brazilian tensile strength

Non-targeted LC-MS metabolomics reveals serum metabolites for high-altitude adaptation in Tibetan donkeys

Synergistic enhancement of electrochemical alcohol oxidation by combining NiV-layered double hydroxide with an aminoxyl radical

High temperature QDs organization and re-crystallization in glass supported MgO QDs doped PMMA film

Hydrological dynamics of the Yangtze river-Dongting lake system after the construction of the three Gorges dam

Drug inhibition and substrate transport mechanisms of human VMAT2

Factors associated with vaccine default in Southern Ghana based on data from the RTSS malaria vaccine trial in Cape Coast

Integrative pan-cancer analysis and experiment validation identified GLS as a biomarker in tumor progression, prognosis, immune microenvironment, and immunotherapy

Supramolecular modification of sustainable high-molar-mass polymers for improved processing and performance

Molecular and biological characterization of infectious full-length cDNA clones of two viruses in Paris yunnanensis, including a novel potyvirus

Biological functions of extracellular vesicle double C2-like domain beta in cervical cancer

Abstract Double C-2 Like Domain Beta (DOC2B) located at 17q13.3 prevents metastasis by senescence induction and epithelial to mesenchymal transition inhibition in cervical cancer (CC). The extracellular vesicle (EV) mediated trafficking of DOC2B and its impact on tumor suppressive activity are not investigated in CC. Using a retroviral method, we first ectopically expressed DOC2B in SiHa, which do not normally express DOC2B. DOC2B-SiHa and vector-SiHa EVs were co-incubated separately with recipient cell and subjected to various cellular and biochemical experiments. For the first time, we demonstrated that DOC2B localizes to EVs, and its transfer to EV may require intracellular calcium. Co-culture of SiHa and HeLa cells with DOC2B-SiHa derived EVs induced morphological changes and suppressed their growth and migration, possibly by induction of G0/G1 to S phase arrest and anoikis. DOC2B-SiHa EVs elevated intracellular reactive oxygen species (ROS) and calcium levels and promoted lipid droplet accumulation and lipid peroxidation rate in recipient cells. DOC2B-SiHa EVs reduced active AKT1 and ERK1/2 levels and EMT marker expression and enhanced cellular senescence and cytotoxic effects of cisplatin. Re-expression of DOC2B significantly altered the global metabolite profile of EVs.  Finally, we demonstrated that intracellular calcium chelation significantly reduces DOC2B localization to EVs and impacts its tumor-suppressive properties. Altogether, EV-mediated DOC2B transfer may reduce the aggressive behavior of CC cells.

Short-term warming supports mineral-associated carbon accrual in abandoned croplands

A radiological study on the relationship between the novel acromial angle and rotator cuff tears

Sounds like gambling: detection of gambling venue visitation from sounds in gamblers’ environments using a transformer

A deep multiple instance learning framework improves microsatellite instability detection from tumor next generation sequencing

Prevalence and risk factors of long COVID-19 persisting for 2 years in Hainan Province: a population-based prospective study

Effect of health literacy-based teach-back training on quality of life and treatment adherence in type 2 diabetes: an experimental study

A flexible catheter-based sensor array for upper airway soft tissues pressure monitoring

AbstractObstructive sleep apnea is a globally prevalent concern with significant health impacts, especially when coupled with comorbidities. Accurate detection and localization of airway obstructions are crucial for effective diagnosis and treatment, which remains a challenge for traditional sleep monitoring methods. Here, we report a catheter-based flexible pressure sensor array that continuously monitors soft tissue pressure in the upper airway and facilitates at the millimeter level. The sensor’s design and versatile 3D femtosecond laser fabrication process enable adaptation to diverse materials and applications. In vitro testing demonstrates high sensitivity (38.1 Ω/mmHg) and excellent stability. The sensor array effectively monitors distributed airway pressure and accurately identifies obstructions in an obstructive sleep apnea animal model. In this work, we highlight the potential of this catheter-based sensor array for long-term, continuous upper airway pressure monitoring and its prospective applications in other medical devices for pressure measurement in human body cavities.