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An enhanced denoising system for mammogram images using deep transformer model with fusion of local and global features
Superior electron transport in the single-crystalline TiCoSb-based half-Heuslers
Cognitive performance classification of older patients using machine learning and electronic medical records
Individual bioenergetic capacity as a potential source of resilience to Alzheimer’s disease
Robust differential microphone array with constant mainlobe width and frequency-invariant directivity factor
Insights from a methylome-wide association study of antidepressant exposure
Abstract This study tests the association of whole-blood DNA methylation and antidepressant exposure in 16,531 individuals from Generation Scotland (GS), using self-report and prescription-derived measures. We identify 8 associations and a high concordance of results between self-report and prescription-derived measures. Sex-stratified analyses observe nominally significant increased effect estimates in females for four CpGs. There is observed enrichment for genes expressed in the Amygdala and annotated to synaptic vesicle membrane ontology. Two CpGs (cg15071067; DGUOK-AS1 and cg26277237; KANK1) show correlation between DNA methylation with the time in treatment. There is a significant overlap in the top 1% of CpGs with another independent methylome-wide association study of antidepressant exposure. Finally, a methylation profile score trained on this sample shows a significant association with antidepressant exposure in a meta-analysis of eight independent external datasets. In this large investigation of antidepressant exposure and DNA methylation, we demonstrate robust associations which warrant further investigation to inform on the design of more effective and tolerated treatments for depression.
Ixazomib or Lenalidomide combined with cyclophosphamide and dexamethasone in the treatment of elderly transplant-ineligible newly diagnosed multiple myeloma
Optimizing selectivity via steering dominant reaction mechanisms in steam reforming of methanol for hydrogen production
Sturnus vulgaris escape algorithm and its application to mechanical design
Author Correction: Targeting pleuro-alveolar junctions reverses lung fibrosis in mice
Effects of substrates on the efficiency of a monocrystalline solar panel
Maternal PRDM10 activates essential genes for oocyte-to-embryo transition
Ventral Midline Hysterectomy, Ovariectomy, and Ovariohysterectomy in Mus Musculus: A Surgical Protocol
Plasma exchange therapy for the post COVID-19 condition: a phase II, double-blind, placebo-controlled, randomized trial
Longevity of neonicotinoid seed treatments in cotton seedlings under various deficit irrigation levels
Ultra-low extracorporeal volume microfluidic leukapheresis is safe and effective in a rat model
Abstract Leukapheresis is a potentially life-saving therapy for children with symptomatic hyperleukocytosis. However, the standard centrifugation-based approach exposes pediatric patients to significant complications due to its large extracorporeal volume, high flow rates, and considerable platelet loss. Here, we tested whether performing cell separation with a high-throughput microfluidic technology could alleviate these limitations. In vitro, our microfluidic devices removed ~85% of large leukocytes and ~90% of spiked leukemic blasts from undiluted human whole blood, while minimizing platelet losses. Multiplexed devices connected in parallel allowed for faster, clinically relevant flow rates in vitro with no difference in leukocyte collection efficiency. When connected to Sprague-Dawley rats, the devices removed large leukocytes with ~80% collection efficiency, reducing the leukocyte count in recirculating blood by nearly half after a 3-hour procedure. Evaluation of plasma biomarkers and end-organ histology revealed no adverse effects compared to sham control. Overall, our study suggests that microfluidics-based leukapheresis is safe and effective at selectively removing leukocytes from circulation, with separation performance sufficiently high to ultimately enable low extracorporeal volume leukapheresis in children.
Vibration response analysis of simply supported girder bridges using millimeter-wave radar measurements
Additively-manufactured monocrystalline YBCO superconductor
Abstract Single-crystal microstructures enable high-performance YBa2Cu3O7-x superconductors which are however limited to simple shapes due to their brittleness. Additive manufacturing can fabricate YBa2Cu3O7-x superconductor with complex shapes, albeit with a polycrystalline microstructure. Here, we demonstrate a route to grow single-crystals from 3D-ink-printed, polycrystalline, sintered superconducting YBa2Cu3O7-x (YBCO or Y123) + Y2BaCuO5 (Y211), manufacturing objects with complex architectures displaying both high critical current density (Jc=2.1 × 104 A.cm–2, 77 K) and high critical temperature (Tc= 88-89.5 K). An ink containing precursor powders (Y2O3, BaCO3, and CuO) is 3D-extruded into complex geometries and then reaction-sintered to obtain polycrystalline Y123 + Y211. A seed is then utilized to transform these 3D-printed parts from polycrystal to monocrystal via the melt growth method. The geometric details of 3D-printed parts survive the process without slumping, sagging or collapse, despite the long-term presence of liquid above the peritectic temperature. Origami structures can be created by sheet folding after 3D-printing. This additive approach enables the facile fabrication of superconducting devices with complex shapes and architectures, such as advanced undulator magnets to generate synchrotron radiation and microwave cavities for dark-matter axion search. This work highlights the potential of additive manufacturing for producing monocrystalline cuprate superconductors and opens the door to additive manufacturing of other monocrystalline functional ceramic or semiconductor materials.