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Where do proteins go in cells? Next-generation methods map the molecules’ hidden lives

Nature Ariana Remmel Apr 10, 2025 DOI: 10.1038/d41586-025-01045-8

Endovascular Treatment of Stroke Due to Medium-Vessel Occlusion

New England Journal of Medicine Mayank Goyal, Johanna M. Ospel, Aravind Ganesh et al. Apr 10, 2025 DOI: 10.1056/nejmoa2411668

A case–control study on vitamin D receptor gene polymorphisms in patients with Parkinson’s disease in Bangladesh

Scientific Reports Narayan Chandra Kundu, Anindya Kundu, Md. Ibrahim Khalil et al. Apr 10, 2025 DOI: 10.1038/s41598-025-96195-0

Plozasiran for Managing Persistent Chylomicronemia and Pancreatitis Risk

New England Journal of Medicine Apr 10, 2025 DOI: 10.1056/nejmc2412616

Advancing diagnosis of feline Leishmania infantum infection through experimental insights

Scientific Reports Akhtardanesh Baharak, Mostafavi Ali, Mostafavi Mahshid et al. Apr 10, 2025 DOI: 10.1038/s41598-025-96698-w

Humans in Africa’s wet tropical forests 150 thousand years ago

Nature Eslem Ben Arous, James A. Blinkhorn, Sarah Elliott et al. Apr 10, 2025 DOI: 10.1038/s41586-025-08613-y

Abstract Humans emerged across Africa shortly before 300 thousand years ago (ka)1–3. Although this pan-African evolutionary process implicates diverse environments in the human story, the role of tropical forests remains poorly understood. Here we report a clear association between late Middle Pleistocene material culture and a wet tropical forest in southern Côte d’Ivoire, a region of present-day rainforest. Twinned optically stimulated luminescence and electron spin resonance dating methods constrain the onset of human occupations at Bété I to around 150 ka, linking them with Homo sapiens. Plant wax biomarker, stable isotope, phytolith and pollen analyses of associated sediments all point to a wet forest environment. The results represent the oldest yet known clear association between humans and this habitat type. The secure attribution of stone tool assemblages with the wet forest environment demonstrates that Africa’s forests were not a major ecological barrier for H. sapiens as early as around 150 ka.

Cancer-Associated Venous Thromboembolism — Beyond 6 Months

New England Journal of Medicine Simon Noble Apr 10, 2025 DOI: 10.1056/nejme2503460

Landslide susceptibility assessment in Tongguan District Anhui China using information value and certainty factor models

Scientific Reports Dan Ding, Yuting Wu, Tianzhen Wu et al. Apr 10, 2025 DOI: 10.1038/s41598-025-93704-z

Extrachromosomal DNA — Amping Up Cancer

New England Journal of Medicine Lillian L. Siu, Trevor J. Pugh Apr 10, 2025 DOI: 10.1056/nejmcibr2415911

Leveraging blockchain and IoMT for secure and interoperable electronic health records

Scientific Reports Soufiane Ben Othman, Masresha Getahun Apr 10, 2025 DOI: 10.1038/s41598-025-95531-8

Revealed: where rare and giant starfish hide from an enigmatic killer

Nature Apr 10, 2025 DOI: 10.1038/d41586-025-00970-y

Extended Reduced-Dose Apixaban for Cancer-Associated Venous Thromboembolism

New England Journal of Medicine Isabelle Mahé, Marc Carrier, Didier Mayeur et al. Apr 10, 2025 DOI: 10.1056/nejmoa2416112

Bearing fault diagnosis based on efficient cross space multiscale CNN transformer parallelism

Scientific Reports Qi Chen, Feng Zhang, Yin Wang et al. Apr 10, 2025 DOI: 10.1038/s41598-025-95895-x

Dapagliflozin in Patients Undergoing Transcatheter Aortic-Valve Implantation

New England Journal of Medicine Sergio Raposeiras-Roubín, Ignacio J. Amat-Santos, Xavier Rossello et al. Apr 10, 2025 DOI: 10.1056/nejmoa2500366

HTS analysis of resistance induction against PPV by four hairpin constructs in Nicotiana benthamiana Domin

Scientific Reports Maryam Ghaderi Sohi, Kahraman Gürcan, Saffet Teber et al. Apr 10, 2025 DOI: 10.1038/s41598-025-97546-7

Aortic Stenosis — When Valve Intervention Is Not Enough

New England Journal of Medicine Ori Ben-Yehuda Apr 10, 2025 DOI: 10.1056/nejme2503345

Spatiotemporal characteristics and influential factors of coupling coordination degree of urbanization and ecological environment in the Huaihe River ecological economic belt

Scientific Reports Xiamei Yao, Yuanyuan Chen, Xudong Zheng et al. Apr 10, 2025 DOI: 10.1038/s41598-025-96612-4

Addressing Socioeconomic Barriers to Residency Choice

New England Journal of Medicine Debra F. Weinstein, Elena Olson, John Patrick T. Co Apr 10, 2025 DOI: 10.1056/nejmp2411273

A real-world descriptive study of screening practices for hydroxychloroquine retinopathy in Japan using an insurance claims database

Scientific Reports Kumiko Kato, Kei Shinoda, Naoto Yokogawa et al. Apr 10, 2025 DOI: 10.1038/s41598-025-96579-2

Case 10-2025: A 32-Year-Old Woman with Flank Pain, Fever, and Hypoxemia

New England Journal of Medicine Anushya Jeyabalan, Cynthia L. Czawlytko, Laurence H. Beck et al. Apr 10, 2025 DOI: 10.1056/nejmcpc2412517