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Identification of a novel disulfidptosis-related gene signature in osteoarthritis using bioinformatics analysis and experimental validation
Retraction Note: Sign language recognition using the fusion of image and hand landmarks through multi-headed convolutional neural network
A novel self-biased pMOS clamped deep trench CSTBT with enhanced tradeoff and short-circuit capability
Forearm elevation impairs local static handgrip endurance likely through reduction in vascular conductance and perfusion pressure: revisiting Rohmert’s curve
AbstractMaximal isometric contraction time (MICT) is critical for most motor tasks and depends on skeletal muscle blood flow at < 40% of maximal voluntary strength (MVC). Whether limb work positions associated with reduced perfusion pressure and facilitated vessel compression affect MICT is largely unknown. In 14 healthy young men we therefore assessed bilateral handgrip MICT at 15, 20, 30, 40, and 70% of MVC in horizontal forearm positions of 0.0, + 27.5 or − 27.5 cm relative to heart level. Forearm blood flow (FBF, venous occlusion plethysmography) and brachial blood pressure were measured repetitively. MICT at 15% MVC was significantly shorter by 66.3 and 86.2 s with forearm position + 27.5 cm (389.6 ± 23.3 s) as compared to 0.0 cm (455.9 ± 34.1 s) and − 27.5 cm (475.8 ± 35.0 s) while MICT at 20–70% MVC was unaffected. Peak FBF at 15% MVC was significantly lower in position + 27.5 cm (11.11 ± 0.92 ml/min/100 ml) compared to 0.0 cm (15.55 ± 0.91 ml/min/100 ml) or − 27.5 cm (14.21 ± 0.59 ml/min/100 ml) and vascular resistance significantly higher in position + 27.5 vs 0.0 or − 27.5 cm. Working position above, but not below heart level may limit MICT at 15% MVC possibly through blood flow reduction arising from increased vascular resistance beside reduced perfusion pressure. Local isometric endurance warrants (re)evaluation regarding hydrostatic/gravitational or other hemodynamic limitations.
Exploring the potential association between serum selenium and hypertension in obese adult males in the United States
Antioxidant Responses in Chromium-Stressed Maize as Influenced by Foliar and Root Applications of Fulvic Acid
Influence of ESBL colonization status on gut microbiota composition during allogenic hematopoietic stem cell transplantation
Development and validation of a prognostic nomogram for predicting outcomes in brainstem hemorrhage patients
Evaluation of fatigue performance of asphalt materials based on their relaxation behavior
Abstract Although the fatigue properties of asphalt materials have been extensively studied, the relationship between the rheological properties and road performance of asphalt mixtures remains underexplored. In this study, we have examined the relaxation properties of asphalt binders through relaxation tests conducted on asphalt and its mastic under different conditions. A repeated stress relaxation-recovery test is designed for assessing both the relaxation and elastic properties, and a set of reasonable test parameters is recommended, thereby establishing a novel test method for measuring the relaxation and elastic behaviors of asphalt. In addition, we have proposed evaluation indexes, such as relaxation time, relaxation rate, and strain recovery rate, to assess the stress relaxation performance and strain recovery ability. It is observed that the relaxation rate and strain recovery rate of the material can be used to characterize the material’s relaxation and elasticity properties, respectively. Thus, the proposed indexes can be used to comprehensively evaluate the viscoelastic performance of the material. The fatigue performance of the selected materials is further examined using the linear amplitude sweep (LAS) test, and the correlation between the relaxation properties and fatigue performance (as indicated by fatigue parameters) is explored. Furthermore, a fatigue performance prediction equation based on the repetitive stress relaxation-recovery test is established. The findings reveal a strong correlation between the relaxation properties and fatigue performance, suggesting that the stress relaxation test can accurately assess the fatigue performance of asphalt materials.
Impact of obesity on iron metabolism and the effect of intravenous iron supplementation in obese patients with absolute iron deficiency
Pharmacovigilance study of the association between progestogen and depression based on the FDA adverse event reporting System (FAERS)
The non-nutritive sweetener rebaudioside a enhances phage infectivity
AbstractNon-nutritive sweeteners (NNS) are widely employed in foodstuffs. However, it has become increasingly evident that their consumption is associated with bacterial dysbiosis, which, in turn, is linked to several health conditions, including a higher risk of type 2 diabetes and cancer. Among the NNS, stevia, whose main component is rebaudioside A (rebA), is gaining popularity in the organic food market segment. While the effect of NNS on bacteria has been established, the impact of these sweeteners on bacterial viruses (phages) has been neglected, even though phages are crucial elements in maintaining microbial eubiosis. The present study sought to provide a proof-of-concept of the impact of NNS on phage infectivity by assessing the binding of rebA to phage proteins involved in the infection process of enteropathogenic bacteria, namely the fiber protein gp17 of Yersinia enterocolitica phage φYeO3-12 and the tubular baseplate protein gp31 of Klebsiella pneumoniae phage 32. We employed docking analysis and a panel of in vitro confirmatory tests (microscale thermophoresis, RedStarch™ depolymerization, adsorption, and lysis rates). Docking analysis indicated that NNS can bind to both fiber and baseplate proteins. Confirmatory assays demonstrated that rebA can bind gp31 and that such binding increased the protein’s enzymatic activity. Moreover, the binding of rebA to gp17 resulted in a decrease in the adsorption rate of the recombinant protein to its host but increased the Yersinia bacteriolysis caused by the whole phage compared to unexposed controls. These results support the hypothesis that NNS can impair phage infectivity, albeit the resulting effect on the microbiome remains to be elucidated.