Browse Articles
Discover research articles across all indexed journals
Fine tuning enzyme activity assays for monitoring the enzymatic hydrolysis of PET
Health risk assessment via ingestion of disinfection by-products in drinking water
Biosynthesized ZnO NPs loaded-electrospun PVA/sodium alginate/glycine nanofibers: synthesis, spinning optimization and antimicrobial activity evaluation
Porous carbons with complex 3D geometries via selective laser sintering of whey powder
Abstract In addition to the inherent limitations of carbons to melt or flow, a vast majority of carbon precursors deforms during carbonisation, with stereolithography of thermoset resins being the preferred technology for 3D printing of carbons. An alternative is now presented with the possibility of using a melting-based technology, selective laser sintering (SLS), to fabricate 3D structures that withstand carbonisation. The key factor that makes this happen is whey powder, a natural, abundant and cheap by-product of the dairy industry. When heating the whey powder with a laser at 180–200 ºC for a few seconds, whey particles sinter, and 3D structures are obtained layer-by-layer. Carbonisation of the sintered whey structures brings about 3D porous carbons with excellent mechanical properties that preserve the SLS printed form albeit an isotropic shrinkage (approx. 23%). Melanoidins are identified as responsible for both the sintering and the thermoset behaviour during carbonisation of the whey powder.
Early life stress, kangaroo care, parenting behavior and secure attachment predict executive functioning in 2 year olds born preterm
Comparative effective dose of ciprofol and propofol in suppressing cardiovascular responses to tracheal intubation
Abstract Ciprofol, a novel γ-aminobutyric acid receptor agonist, outperforms propofol with minimal cardiovascular effects, higher potency, reduced injection pain, and a broader safety margin. Despite these advantages, ciprofol’s clinical research is still emerging. This study compares the median effective dose (ED 50 ) and adverse reactions of ciprofol and propofol, in conjunction with sufentanil, for suppressing cardiovascular responses during tracheal intubation. Fifty-three adult patients scheduled for tracheal intubation under general anesthesia were enrolled and randomly assigned to receive either ciprofol (Group C) or propofol (Group P), according to a random number table. Tracheal intubation was performed using a standardized laryngoscope and endotracheal tube. The Dixon’s up-and-down method was employed to determine the ED 50 and 95% effective dose (ED 95 ) of ciprofol and propofol in inhibiting cardiovascular responses during tracheal intubation. Based on the pilot study, the initial dose for ciprofol was set at 0.35 mg/kg (with a 0.01 mg/kg increment) and for propofol at 2.0 mg/kg (with a 0.1 mg/kg increment). Probit analysis was applied to derive dose-response curves, while adverse reactions were continuously monitored. A total of 54 participants were included, with 24 in group C (1 excluded) and 30 in group P. Probit analysis revealed that the ED 50 of ciprofol for inhibiting cardiovascular responses to tracheal intubation were 0.326 mg/kg (95% CI 0.304–0.337 mg/kg), and for propofol, 1.541 mg/kg (95% CI 1.481–1.599 mg/kg). The heart rate in group P was significantly higher than the group C at 1 minute ( p = 0.026) and 3 minutes ( p = 0.016) post-intubation. Systolic and diastolic blood pressures (SBP and DBP) decreased significantly before and after intubation compared to baseline values in both groups ( p < 0.05). Group C experienced significantly less injection pain ( p = 0.001), although the incidence of other adverse effects was not statistically different between groups ( p > 0.05). Clinical Trial Registration : hppts://ClinicalTrials.gov; Identifier: NCT06095570(18/10/2023).
Nematode controlling effects and safety tests of Duddingtonia flagrans biological preparation in sheep
Uniform impact on individual megakaryocytes is essential for efficient in vitro platelet production
Transcription factor FOXD1 and miRNA-204-5p play a major role in B4GALNT2 downregulation in colon cancer
Attenuation of progressive surface gravity waves by floating spheres
The role of impulsivity and emotional dysregulation in smartphone overdependence explored through network analysis
Green synthesized FeNPs ameliorate drought stress in Spinacia oleracea L. through improved photosynthetic capacity, redox balance, and antioxidant defense
Biocompatible autonomous self-healing PVA-CS/TA hydrogels based on hydrogen bonding and electrostatic interaction
Mechanical response of elevated bridge piles to adjacent deep excavation
Selective fluoride ion sensing using novel quinoline chemosensor insights into kinetics and molecular logic gate functions
Efficacy of melatonin treatment in a cystic fibrosis mouse model of airway infection
Experimental study on the influence of lapping plate materials on the quality of both sides cylindrical rollers machining
Development of immune-derived molecular markers for preeclampsia based on multiple machine learning algorithms
Study of blood flow patterns in a stenosed artery through the combined effect of body acceleration and generalized womersley solution
Abstract Stenosis causes the narrowing of arteries due to plaque buildup, which impedes blood flow and affects flow dynamics. This work numerically analyzes flow fluctuations in stenosed arteries under realistic physiological conditions (resting and exercise) and external body acceleration. The artery is inclined at angle $$\Theta$$ Θ , and blood rheology is modeled using a generalized power-law fluid. A modified two-dimensional SIMPLE pressure-correction-based numerical solver with orthogonal coordinate transformation simulates blood flow. A generalized Womersley solution is imposed at the inlet. We validate the solver and perform simulations to assess the influence of geometric and flow parameters, analyzing time-averaged and phase-averaged data. We investigate the correlation between hyperviscosity and physiological conditions, finding that exercise increases recirculation downstream of the stenosis. We also study the impact of transitioning between resting and exercise conditions, noting that the transition rate correlates with stenosis development, indicating potential complications.