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Janus graphene nanoribbons with localized states on a single zigzag edge
Bland–Altman plot to assess the consistency of arterial and venous blood lactate in the emergency room: a retrospective cohort study
Fractional tackles: leveraging player tracking data for within-play tackling evaluation in American football
Abstract Tackling is a fundamental defensive move in American football, with the main purpose of stopping the forward motion of the ball-carrier. However, current tackling metrics are manually recorded outcomes that are inherently flawed due to their discrete and subjective nature. Using player tracking data, we present a novel framework for assessing tackling contribution in a continuous and objective manner. Our approach first identifies when a defender is in a “contact window” of the ball-carrier during a play, before assigning value to each window and the players involved. This enables us to devise a new metric called fractional tackles, which credits defenders for halting the ball-carrier’s forward motion toward the end zone. We demonstrate that fractional tackles overcome the shortcomings of traditional metrics such as tackles and assists, by providing greater variation and measurable information for players lacking recorded statistics like defensive linemen. We view our contribution as a significant step forward in measuring defensive performance in American football and a clear demonstration of the capabilities of player tracking data.
What will viruses do next? AI is helping scientists predict their evolution
Integrated analysis of cellulose structure and properties using solid-state low-field H-NMR and photoacoustic spectroscopy
Abstract In this study, we explore the structural intricacies of cellulose, a polymer composed of glucose monomers arranged in a linear chain, primarily investigated through solid-state NMR techniques. Specifically, we employ low-field proton nuclear magnetic resonance (H-NMR) to delve into the diverse hydrogen atom types within the cellulose molecule. The low-field H-NMR technique allows us to discern these hydrogen atoms based on their distinct chemical shifts, providing valuable insights into the various functional groups present in cellulose. Our focus extends to the examination of anomeric protons of glucose units and protons linked to carbon atoms engaged in glycosidic linkages within cellulose chains, which exist in diverse crystalline and amorphous forms. Solid-state low-field H-NMR spectroscopy aids in characterizing the crystallinity degrees and amorphous regions within cellulose, revealing time-dependent changes in free induction decay (FID) signals. Complementing this, we investigate the photo-absorption properties of cellulose fibers under both continuous and modulated irradiation using reversed double-beam photoacoustic spectroscopy (RDB-PAS). This photoacoustic approach allows us to observe ultraviolet- and visible light-induced processes, including electron trap filling and reductive changes on the fiber surface. Our findings suggest that RDB-PAS is a feasible method for estimating the electron trap distribution, serving as a potential measure of the density of crystalline cellulose defects. This integrated approach of combining solid-state low-field H-NMR and RDB-PAS techniques offers a comprehensive understanding of cellulose structure and properties, enhancing our ability to characterize its diverse features.
New Silurian aculiferan fossils reveal complex early history of Mollusca
Abstract Mollusca is the second most species-rich animal phylum, but the pathways of early molluscan evolution have long been controversial1–5. Modern faunas retain only a fraction of the past forms in this hyperdiverse and long-lived group. Recent analyses6–8 have consistently recovered a fundamental split into two sister clades, Conchifera (including gastropods, bivalves and cephalopods) and Aculifera9, comprising Polyplacophora (‘chitons’) and Aplacophora. Molluscan evolution in toto is characterized by plasticity in body-plan characters10, but historically aculiferans have been interpreted as more conservative10,11. The few completely preserved aculiferan or aculiferan-like fossils from the early Palaeozoic12–19 have been largely regarded as transitional forms that inform questions of character polarity between the extant polyplacophoran and aplacophoran body forms20,21. The history of early aculiferans, and the morphological and ecological range that they occupied, remain inadequately sampled. Here we describe two new three-dimensionally preserved aculiferan species from the Silurian Herefordshire Lagerstätte22,23, which substantially extend the morphological and ecological range of the clade. Phylogenetic analyses indicate positions within a complex nexus of taxa and suggest reversals in the states of fundamental characters such as the presence of valves and the nature of the foot. In contrast to previous hypotheses of morphological conservatism, evolution in early aculiferans generated a profusion of unusual forms comparable to the diversification of other crown-group molluscs.
Transmission of transgenic mosquito-killing fungi during copulation
Brief exposure to (-) THC affects zebrafish embryonic locomotion with effects that persist into the next generation
Investigation of the optimum calcination temperature for water treatment plant sludge to develop a sustainable alkali activated concrete
Abstract Nowadays, Egypt is treating the Nile River Water to produce drinking water, and this process generates large amounts of waste, around 635 million m3 annually, which is called water treatment plant sludge (WTPS). This WTPS cost the government around 30 million US dollars to return it back to the Nile River in addition to negatively affecting the environment. Therefore, there is an urgent need to find environmentally friendly alternatives that reduce the impact of such an issue. This paper focuses on treating WTPS by drying, grinding and calcining to develop it as an alternative binder for use in alkali-activated concrete. This approach would not only provide green construction material but also reveal an environmental disposal route for the sludge produced in Egypt or in any country has the same issue. The treatment methodology used in this study was based on finding the optimum calcination temperature regime for WTPS after drying and grinding. Fifteen specimens of WTPS powder were used to investigate the optimum calcination temperature and duration by applying different temperatures ranging from 500 °C to 800 °C for various exposure durations of 30, 60 and 90 min. XRD and Chapelle tests were employed to chemically investigate the efficiency of the obtained calcined WTPS specimens, while strength activity index and compressive strength tests were used to mechanically verify the findings of the chemical tests. The results indicated that the calcination regime, which involved applying a maximum temperature of 650 °C for 90 min, achieved the best chemical characteristics and a strength activity index of 145%. Moreover, this regime resulted in a compressive strength of 21 MPa when WTPS powder was used as a precursor in alkali-activated concrete. Additionally, this paper presented a brief comparison of the production cost and energy consumption between cement and WTPS. The comparison demonstrated the efficiency of using WTPS as a replacement for cement, showing that the production of WTPS costs 50% less and consumes 92% less energy than cement.
NASA still has no plan for how to bring precious Mars rocks to Earth
Clinical implementation of next-generation sequencing testing and genomically-matched therapy: a real-world data in a tertiary hospital
Resin composite aggregated S-PRG particles are not superior to non-S-PRG under microcosm biofilm
A simplified computational liver perfusion model, with applications to organ preservation
Abstract Advanced liver preservation strategies could revolutionize liver transplantation by extending preservation time, thereby allowing for broader availability and better matching of transplants. However, developing new cryopreservation protocols requires exploration of a complex design space, further complicated by the scarcity of real human livers to experiment upon. We aim to create computational models of the liver to aid in the development of new cryopreservation protocols. Towards this goal, we present an approach for generating 3D models of the liver vasculature by building upon the space colonization algorithm. Additionally, we introduce the concept of a super lobule which enables a computational abstraction of biological liver lobules. User-tunable parameters allow for vasculatures of varying depth and topology to be generated. In each model, we solve for a common lumped resistance value assigned to the super lobules, allowing the overall physiological blood pressure and flow rate through the liver to be preserved. We demonstrate our approach’s ability to maintain consistency between models of varying depth. Finally, we simulate steady state machine perfusion of the generated models and demonstrate how they can be used to quickly test the effect of different boundary conditions when designing organ preservation protocols.
Author Correction: Performances and determinants of proficiency testing in clinical laboratory services at comprehensive specialized hospitals, northwest Ethiopia
Analytical model for helical particle array assessment for EMI shielding applications
Uniaxial compressive damage evolution and constitutive modeling of fissure-like rocks under different loading rates based on acoustic emission
Particle accelerators get an assist from AI co-pilots
Optimal parameter identification of photovoltaic systems based on enhanced differential evolution optimization technique
RED light promotes flavonoid and phenolic accumulation in Cichorium spp. callus culture as anti-candida agent
Abstract Chicory species, particularly Cichorium endive Supp. Pumillum, also, known as Egyptian chicory, are globally recognized for their rich content of bioactive secondary metabolites such as flavonoids and phenolics. These metabolites are highly valued for their pharmaceutical, dietary, and commercial applications. Light exposure, particularly through red and blue wavelengths, is a potent natural elicitor that influences the biosynthesis of secondary metabolites and impacts plant morphology. This study investigates the effects of red and blue LED light exposure on the callus culture of Egyptian chicory (Cichorium endive Supp. Pumillum), with the aim of enhancing flavonoid accumulation for potential use as an anti-Candida agent. Callus cultures of Cichorium intybus, Cichorium endive Supp. Pumillum, and Taraxacum officinale (Italian chicory) were grown on MS media supplemented with 4 mg/L 2iP and 0.5 mg/L NAA for 4 weeks. The cultures were then exposed to 12 days of red and blue LED light. After extraction using liquid nitrogen and methanol, the resulting callus extracts were tested against Candida albicans NRRL477 at various concentrations (1/8, 1/4, and 1/2 MIC) for 20 to 120 min. The antifungal activity was assessed by determining the effects on acid-soluble phosphorus, total lipids, and soluble proteins in the Candida cells. Our results demonstrate that the red LED light-exposed Cichorium endive Supp. Pumillum callus extract exhibited the most potent antifungal activity, significantly inhibiting the growth of Candida species compared to blue light and control treatments. Notably, the red light-treated callus culture accumulated higher concentrations of flavonoids and phenolic compounds, which contributed to its effectiveness as an anti-Candida agent. These findings suggest that LED red light elicitation is an effective method for enhancing the production of bioactive compounds in Egyptian chicory, offering potential for its use in natural antifungal therapies. Future research will explore the mechanistic pathways of flavonoid accumulation under different light conditions and investigate the broader applications of this elicitation technique for other medicinal plants.