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Pioneering CERN scheme will pay publishers more if they hit open-science targets
The Pediatrician’s Lament
The first insight into Acanthocephalus (Palaeacanthocephala) satellitome: species-specific satellites as potential cytogenetic markers
Multimodal Treatment in Locally Advanced Esophageal Adenocarcinoma — Two Interventions Better Than Three?
Prehospital scale to differentiate intracerebral hemorrhage from large-vessel occlusion patients: a prospective cohort study
Perioperative Chemotherapy or Preoperative Chemoradiotherapy in Esophageal Cancer
Risk effects of environmental factors on human brucellosis in Aksu Prefecture, Xinjiang, China, 2014–2023
‘Never seen anything like this’: Trump’s team halts NIH meetings and travel
Gender-Affirming Surgical Care in Carceral Settings
An experimental study on the synergic damage of chemical solutions and stress to coal
Daily briefing: Cancer ‘poisons’ the immune system by giving it faulty machinery
Uncoupling Thrombosis and Hemostasis by Inhibiting Factor XI
ACOX1 activates autophagy via the ROS/mTOR pathway to suppress proliferation and migration of colorectal cancer
Treatments for Dupuytren’s Contracture
AHNAK2: a potential diagnostic biomarker for pancreatic cancer related to cellular motility
Abstract Pancreatic ductal adenocarcinoma lacks suitable biomarkers for early diagnosis of disease. In gene panels developed for early diagnosis of pancreatic cancer, high AHNAK2 mRNA expression was one possible biomarker. In silico analysis of published human sample datasets (n = 177) and ex vivo analysis of human plasma samples (n = 30 PDAC with matched 30 healthy control) suggested AHNAK2 could be a diagnostic biomarker. At a plasma level of 421.47 ng/ml, AHNAK2 could potentially diagnose PDAC with a specificity and sensitivity of 83.33% and 86.67%. In vitro analysis suggests that in cell lines with diffuse cytoplasmic distribution of AHNAK2, there was colocalization of AHNAK2 with Cortactin in filipodia. This colocalization increased when cells were cultured on substrates such as Fibronectin and Collagen, as well as in hypoxia, and resulted in an augmented invasion of cancer cells. However, in cell lines with a vesicular AHNAK2 staining, such changes were not observed. Our study posits AHNAK2 as a valuable diagnostic biomarker in PDAC, now demanding prospective validation. Determination of mechanisms regulating AHNAK2 subcellular localisation may help explain its biological role.
Neuromorphic computing at scale
The Role of Importation in Remediating U.S. Generic Drug Shortages
3D numerical modeling of the deformation and failure mechanisms of batter pile groups subjected to fault ruptures
Abstract Fault ruptures induced by earthquakes pose a significant threat to constructions, particularly underground structures such as pile foundations. Among various foundation types, batter pile foundations are widely used due to their ability to resist inclined forces. To gain new insights into the response of batter pile groups to fault ruptures caused by earthquakes, this study investigates the deformation and failure mechanisms of batter pile groups due to the propagation of normal and reverse fault ruptures using 3D numerical modeling. An advanced hypoplastic constitutive model for clay, which accounts for small-strain stiffness, and a concrete damage plasticity (CDP) model are employed to simulate the soil and the batter pile foundation, respectively. Results show that following fault propagation, nearly 10% tilting and significant displacement occurred at the pile cap, indicating a total failure of the batter pile foundation. It was also observed that the piles bent towards the slipping direction of the hanging wall. Tensile damage to the pile foundation was notably more severe than compression damage. The most severely damaged regions were not only located at the joints between the piles and the pile caps but were also found along the pile shafts.