Browse Articles

Multistage deep learning methods for automating radiographic sharp score prediction in rheumatoid arthritis

Data-driven exploration of weak coordination microenvironment in solid-state electrolyte for safe and energy-dense batteries

Binocular stereo vision-based relative positioning algorithm for drone swarm

A compendium of Amplification-Related Gain Of Sensitivity genes in human cancer

Abstract While the effect of amplification-induced oncogene expression in cancer is known, the impact of copy-number gains on “bystander” genes is less understood. We create a comprehensive map of dosage compensation in cancer by integrating expression and copy number profiles from over 8000 tumors in The Cancer Genome Atlas and cell lines from the Cancer Cell Line Encyclopedia. Additionally, we analyze 17 cancer open reading frame screens to identify genes toxic to cancer cells when overexpressed. Combining these approaches, we propose a class of ‘Amplification-Related Gain Of Sensitivity’ (ARGOS) genes located in commonly amplified regions, yet expressed at lower levels than expected by their copy number, and toxic when overexpressed. We validate RBM14 as an ARGOS gene in lung and breast cancer cells, and suggest a toxicity mechanism involving altered DNA damage response and STING signaling. We additionally observe increased patient survival in a radiation-treated cancer cohort with RBM14 amplification.

Development and validation of a prognostic nomogram for predicting of patients with acute sedative-hypnotic overdose admitted to the intensive care unit

Splicing accuracy varies across human introns, tissues, age and disease

Abstract Alternative splicing impacts most multi-exonic human genes. Inaccuracies during this process may have an important role in ageing and disease. Here, we investigate splicing accuracy using RNA-sequencing data from >14k control samples and 40 human body sites, focusing on split reads partially mapping to known transcripts in annotation. We show that splicing inaccuracies occur at different rates across introns and tissues and are affected by the abundance of core components of the spliceosome assembly and its regulators. We find that age is positively correlated with a global decline in splicing fidelity, mostly affecting genes implicated in neurodegenerative diseases. We find support for the latter by observing a genome-wide increase in splicing inaccuracies in samples affected with Alzheimer’s disease as compared to neurologically normal individuals. In this work, we provide an in-depth characterisation of splicing accuracy, with implications for our understanding of the role of inaccuracies in ageing and neurodegenerative disorders.

Integrating mitochondrial and lysosomal gene analysis for breast cancer prognosis using machine learning

Triboelectric sensor gloves for real-time behavior identification and takeover time adjustment in conditionally automated vehicles

Aspect category sentiment analysis based on pre-trained BiLSTM and syntax-aware graph attention network

STAIG: Spatial transcriptomics analysis via image-aided graph contrastive learning for domain exploration and alignment-free integration

A photodetector for red and green with balanced negative and positive photocurrent for imaging is realized

Simultaneous aerobic and anaerobic respiration in hot spring chemolithotrophic bacteria

Long-term surgical outcomes of esotropic duane retraction syndrome type 1

GPX modulation promotes regenerative axonal fusion and functional recovery after injury through PSR-1 condensation

Clinical characteristics and prognosis of patients treated as invasive pulmonary aspergillosis outside of severe immunosuppression

Tailorable biosensors for real-time monitoring of stress distribution in soft biomaterials and living tissues

Varying effects of Vicia sativa and Vicia villosa on bacterial composition and enzyme activities in nutrient-deficient sugarcane soils under greenhouse conditions

Flow chemistry-enabled asymmetric synthesis of cyproterone acetate in a chemo-biocatalytic approach

Fe3O4@HA-Cu(OAc)2 nanocomposite as a nanomagnetic water-compatible catalyst for efficient synthesis of 1,2,3-triazoles in water

Reproducibility and transparency: what’s going on and how can we help