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Monitoring benthic plumes, sediment redeposition and seafloor imprints caused by deep-sea polymetallic nodule mining
Abstract A deep-sea (4500 m) trial of a pre-prototype polymetallic nodule collector with independent scientific monitoring revealed that a gravity current formed behind the collector channeled through steeper seafloor sections and traveled 500 m downslope. The prevailing bottom currents dominated sediment dispersion up to the end of the monitoring area at 4.5 km distance. The maximum suspended particle concentration recorded 50 m from mining lanes was up to four orders of magnitude higher than ambient values but decreased rapidly with increasing time, distance, and altitude. Most of the plume remained close to the seafloor, with the highest concentrations at 1 m monitoring altitude and reaching background concentrations at 50 m. Rapid particle flocculation was followed by fast and substantial sediment redeposition. A mm-scale photogrammetric seafloor reconstruction allowed quantitative estimates of the thickness of redeposited sediment next to mining lanes of ≈ 3 cm and a minimum erosional depth of 5 cm.
Intubation during Uninterrupted Chest Compressions: How Easy?
Transformer-generated atomic embeddings to enhance prediction accuracy of crystal properties with machine learning
Blue Hopes, Red Flags: The Methylene Blue Dilemma in Sepsis Shock
I’ve been wrongly accused of bullying — what do I do?
A multi-omics spatial framework for host-microbiome dissection within the intestinal tissue microenvironment
Prognostic Significance of Driving Pressure for Initiation and Maintenance of ECMO in Patients with Severe ARDS: A Systematic Review and Meta-analysis
‘There is life after burnout in academia’
MetaQ: fast, scalable and accurate metacell inference via single-cell quantization
Decision-making Preferences and Levels of Anxiety and Depression in Family Members of Patients Admitted to the ICU
Sub-nanometer depth resolution and single dopant visualization achieved by tilt-coupled multislice electron ptychography
Abstract Real-space, three-dimensional imaging of atomic structures in materials science is a critical yet challenging task. Although scanning transmission electron microscopy has achieved sub-angstrom lateral resolution through techniques like electron ptychography, depth resolution remains limited to only 2 to 3 nanometers using single-projection setups. Attaining better depth resolution often requires large sample tilt angles and numerous projections, as demonstrated in atomic electron tomography. Here, we introduce an extension of multislice electron ptychography, which couples only a few small-angle projections to improve depth resolution by more than threefold, reaching the sub-nanometer scale and potentially approaching the atomic level. This technique maintains high resolving power for both light and heavy atoms, significantly enhancing the detection of individual dopants. We experimentally demonstrate three-dimensional visualization of dilute praseodymium dopants in a brownmillerite oxide, Ca2Co2O5, along with the accompanying lattice distortions. This approach can be implemented on widely available transmission electron microscopes equipped with hybrid pixel detectors, with data processing achievable using high-performance computing systems.
Author Response: Balanced Electrolyte Solutions in Diabetic Ketoacidosis: Where does Sterofundin Stand?
Daily briefing: Former NIH director Monica Bertagnolli talks Trump
Lymphatic-derived oxysterols promote anti-tumor immunity and response to immunotherapy in melanoma
Peripheral Perfusion Index for Prediction of Fluid Responsiveness in Spontaneously Breathing Critically Ill Patients: A Prospective Observational Study
The AI revolution is running out of data. What can researchers do?
The zinc-finger transcription factor Blimp1/Prdm1 is required for uterine remodelling and repair in the mouse
Abstract The zinc finger transcription factor Blimp1/PRDM1 regulates gene expression in diverse cell types. Its activity controls the maternal decidual response at early post-implantation stages of development. The present experiments demonstrate surprisingly that Blimp1 activity in the uterus is required for tissue remodelling at sites of embryonic failure. Moreover Blimp1 mutant females are refractory to RU486 induced decidual shedding. RNA-seq together with immunostaining experiments strongly suggest that the failure to up-regulate expression of the matrix metalloprotease Mmp10 in combination with insufficient suppression of BMP signalling, likely explain Blimp1-dependent phenotypic changes. In the post-partum uterus Blimp1 together with Mmp10 are highly upregulated at sites of tissue repair following placental detachment. Conditional Blimp1 removal significantly impairs the re-epithelization process and severely impacts involution of the endometrium and luminal epithelium. Overall these results identify Blimp1 as a master regulator of uterine tissue remodelling and repair.
Effects of Early Use of Methylene Blue and Vasopressin on Noradrenaline Dose in Septic Shock: A Randomized Controlled Trial
Resolving active species during the carbon monoxide oxidation over Pt(111) on the microsecond timescale
Abstract Catalytic studies traditionally rely on steady-state conditions resulting in time-averaged datasets that do not differentiate between active and spectator species. This limitation can cause misinterpretations of catalytic function, as the signal of short-lived intermediates responsible for producing desired reaction products is often masked by more intense spectator species. Time-resolved ambient pressure X-ray photoelectron spectroscopy (tr-APXPS) mitigates this issue by combining microsecond time resolution under reaction conditions. Using tr-APXPS, we investigate the oxidation of CO over Pt(111) by concurrently tracking reaction products, surface intermediates, and catalyst response. Our findings reveal that chemisorbed oxygen, rather than Pt surface oxide, is the main species reacting with CO to form CO 2 , supporting a primary Langmuir-Hinshelwood mechanism. The results shed new light on a heavily-debated reaction in catalysis. Beyond using CO pulses to determine active species, we demonstrate how careful tuning of pulsing parameters can be used for dynamic catalyst operation to enhance CO 2 formation.