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Prediction of clinical stages of cervical cancer via machine learning integrated with clinical features and ultrasound-based radiomics
Altered levels of angiogenin and tRNA-derived fragments associate with severe asthma
In-silico study of lanthanide-based nanoparticles for dual-modal photoacoustic and MRI theranostics
Migration and population characteristics of white-naped cranes wintering on the Korean Peninsula
Microstructure and phase evolution in increasing the amount of mo and Ti of non-equiatomic CoFeNi-based medium entropy alloys for organic wastewater treatment
Abstract The effect of the combined addition of Mo and Ti on the phase evolution of non-equiatomic (CoFeNi)100−2.5xMoxTi1.5x (x = 2,4,6,8,10,12) alloys produced by high-energy ball-milling was investigated. Based on the preliminary phase stability criteria, solid solution formation is expected for each composition, a face-centred structure (FCC) phase if x is less than 10, and FCC and body-centred structure (BCC) phase in other cases. After 35 h of milling, solid solution structures were successfully produced in all samples; an FCC, two BCC structure phases, and a small amount of Co phase were identified based on X-ray diffraction. One of the BCC phases is Mo-based (BCC1(Mo)), while the other is a Fe-based (BCC2(Fe) solid solution. Increasing the combined amount of Mo and Ti alloying up to 20 at% (x = 8), the amount of the FCC structure was dominant, while above 20 at% (x = 10), the amount of the two BCC lattice structures was predominant. The average particle sizes were smaller than 3 μm. The specific surface area of all composition powders was less than 0.25 m2/g, which is extremely rare for a catalyst. All HEA powders containing Mo and Ti demonstrated enhanced photocatalytic activity in the decolorisation of Rhodamine B dye (RhB). The optimum conditions for RhB decolorisation were a pH of 2 and a catalyst dosage of 1 g/L. Under these conditions, (CoFeNi)85Mo6Ti9, (CoFeNi)80Mo8Ti12, and (CoFeNi)70Mo12Ti18 demonstrated high efficiencies of 97.6, 98.6 and 98.7%, respectively, already in the first minute of reaction.
Taking common medicines might matter for cancer treatment
The involvement of the synaptic vesicle cycle in homocysteine induced neurotoxicity in vitro and in vivo
Abstract Homocysteine (Hcy), a sulfur-containing amino acid derived from methionine, has been shown to be a significant and modifiable risk factor for various neurological disorders, including stroke, Parkinson’s disease, Alzheimer’s disease, and elderly depression. However, there is currently a lack of comprehensive understanding regarding the molecular mechanisms underlying Hcy-induced neurotoxicity. Therefore, this study aimed to establish rat and cell models of Hcy intervention in order to elucidate the underlying mechanism of neurotoxicity. Our research findings demonstrate that Hcy induces depressive - like symptoms in normal Sprague-Dawley rats. Pathological damage and apoptosis were detected in the DG, CA3, and CA1 regions of the hippocampus, along with the cortical area. Moreover, synaptic structural impairment was observed within the hippocampal. Simultaneously, Hcy promotes neuronal apoptosis and LDH leakage in mouse neuroblastoma (N2a) cells. Furthermore, we conducted mRNA microarray analysis to investigate differences in mRNA expressions and utilized Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis for gene function annotations in Hcy-treated N2a cells. The results highlighted significant alterations in 457 mRNAs in the Hcy-treated group compared to the Control group. Among the differentially expressed genes (DEGs), a total of 155 were found to be significantly up-regulated, while the remaining 302 were down-regulated. Furthermore, it was observed that four genes (snap25, cplx1, slc32a1 and atp6v1e2) related to the synaptic vesicle cycle exhibited decreased expression in Hcy-treated N2a cells compared to the Control group. The expression levels of these four genes, as well as their corresponding proteins, were subsequently confirmed using RT-qPCR and western blot analysis, respectively. In conclusion, this study shed light on the detrimental impact of hyperhomocysteinemia on the nervous system, particularly with regard to the synaptic vesicle cycle.