Browse Articles

High blood pressure inhibits cardiovascular responsiveness to expressive classical music

Abstract Music lowers hypertensive patients’ blood pressure (BP) in the long-term, but the dynamics of BP during music-listening are not well understood. This study aims to determine: (1) whether individuals with high and normal BP respond to music differently; and, (2) whether music’s loudness or tempo drives these differences. Music with computer-altered tempo and loudness is rendered on a reproducing piano to 40 middle-aged participants, 20 with baseline BP above 140/90 mmHg (H-bBP) and 20 below (N-bBP) but above 90/60 mmHg, paired by playlist. Continuous BP was recorded whilst they listened to playlists of 9 tempo- and loudness-transposed versions of 8 distinct pieces of Western classical music (40 min) after a 5-minute baseline silence. Both participant groups’ mean systolic and diastolic BP rose significantly higher than baseline during music listening, with normotensives’ mean systolic and diastolic BP rising significantly more than hypertensives’. Both groups’ BP variability (indexed by range and standard deviation of continuous BP measurements) reduced during faster tempi, but not during increased loudness. BP variability is significantly higher for both groups during the slowest pieces, which maintain the originally performed tempi. These findings suggest that music’s long-term benefit, like exercise, may come from its power to temporarily physiologically activate listeners.

Aerial manipulation of long objects using adaptive neuro-fuzzy controller under battery variability

Abstract Aerial manipulation provides adaptable solutions for executing tasks in constrained environments, particularly in civil engineering and disaster response. This paper presents a UAV-based aerial manipulation system for the precise handling and transportation of long objects, such as pipes, in uncertain conditions. Compared to single- or dual-arm systems, which are difficult to scale and maintain, the proposed design features a modular two-finger gripper, enhancing scalability and reliability while reducing mechanical complexity. To address challenges such as positional drift, which can compromise mission success, the system employs a SO-BFBEL controller controller to enhance stability and precision and it is compared with DNN-MRFT-based PID and Fuzzy SMC controller. Experimental results demonstrate that the SO-BFBEL controller reduces the position tracking error up to 50% and compensates for wind disturbances and battery discharge fluctuations more effectively than conventional methods. Additionally, the SO-BFBEL controller can help to conserve battery life during manipulation phases which can boost the operational efficiency without incurring any additional costs.

Convolutional neural network analysis of optical texture patterns in liquid-crystal skyrmions

Role of soluble interleukin-2 receptor (sIL-2R) as a predictor for severe dengue infection

Noise and sound in the intensive care unit: a cohort study

Abstract Intensive care units (ICUs) are acknowledged for their propensity for noise, often exhibiting higher sound levels on average than other departments. This is mainly ascribed to a high concentration of medical devices and staff, creating an acoustic environment characterised by a high level of staff activity and a concoction of alarms from therapeutic and monitoring devices. Excessive noise in ICUs has been associated with adverse health effects and human factor impacts acknowledged to negatively affect both patients and healthcare providers. This study aimed to evaluate the sound levels of the Royal Liverpool University Hospital (RLUH) ICU and compare it against recommended guidelines. Prospective sound level measurements were taken from a six-bedded bay within the RLUH ICU between 15th June and 1st July 2022. This audit focussed on sound data that equal or exceeded 87 dBA, in accordance with levels in the UK Noise Regulations. The data involved 11 patients admitted to the bay within the defined timeframe. A retrospective review of the patients’ records was conducted to identify potential noisy events during the recording period. Results revealed all LAeq and L Amax measurements exceeded the recommended guidelines. Although HSE exposure limit values were not exceeded, the lowest L Amin value recorded was 44.2 dBA and only one hour from 16 days of recording (less than 1% of the time) fell below international daytime guidelines of 45 dBA. The top documented potential causes of noise were patient repositioning/personal care, medication administration and suctioning. Sound levels in the RLUH ICU considerably exceed national and international guidelines. These findings highlight the need to address the issue of noise pollution in the ICU setting. Hospital staff should consider implementing strategies and interventions for noise reduction in ICUs.

Simulator training for enhanced interventional radiology education

Abstract To address the challenges of staff shortages and the need to gain practical experience in interventional radiology by increasing attention in the medical curriculum, especially in combination with the opportunity to successfully gain hands-on experience, can help influence medical students’ career decisions in favor of IR. Regular training on VR simulators can reduce the amount of X-ray radiation needed to adequately care for patients. Ten medical students underwent five angiographic training sessions using an endovascular simulator. Virtual fluoroscopy time was recorded during each session to measure skill development. Pre- and post-training questionnaires were conducted to assess changes in subjective proficiency and career interests. The median virtual fluoroscopy time decreased from 19.3 min initially to 9.3 min ( p  = 0.007), indicating enhanced procedural proficiency. Post-training questionnaires revealed a notable increase in interest in interventional radiology among participants. Additionally, participants reported improvements in practical skills, understanding of interventional radiology, and readiness for real-world interventions. Simulator-based training significantly enhances procedural proficiency and could impact career interests in interventional radiology. Despite the small sample size, the findings support the efficacy of VR training in medical education, highlighting the need for further research to optimize the implementation of simulation technology in medical training.

An automated parallel genetic algorithm with parametric adaptation for distributed data analysis

Heterologous expression and enzymatic properties of lipase from Mucor circinelloides

Sustainable production of osteoinductive Co2+, Mg2+ and Mn2+ -substituted apatites particles by one-pot conversion of biogenic calcium carbonate

Abstract Biogenic CaCO3 microparticles obtained from oyster shells Crassostrea gigas were used as starting material for synthesizing Co2+, Mg2+ and Mn2+-doped apatite nano-submicroparticles, through a one-step hydrothermal conversion. The conversion was completed at 200 °C for 7 days, yielding metal-doped apatite and whitlockite in percentages of 5.3 wt% when adding Co2+, 28.7 wt% for Mg2+, and 0 wt% for Mn2+. Samples were cytocompatible with murine pancreatic endothelial cells (MS1), murine mesenchymal stem cells (m17.ASC), and murine osteoblast’s progenitors (mOBPs) cells. The analysis by flow cytometry and TEM–EDX revealed strong particle–cell interactions, sustained internalization across m17.ASC and mOBPs cells, and potential progressive apatite dissolution in the cellular environment. Additionally, incubating these cells with the metal-doped samples promoted their osteogenic differentiation without needing an osteogenic differentiation medium. Indeed, the evaluation of gene expression by quantitative real-time PCR, the detection of alkaline phosphatase activity, and the ability to induce the mineralization in the cellular matrix analyzed by alizarin red staining revealed that all particles (and particularly the carbonated apatite and the Mg-doped sample) encouraged the osteogenic commitment. This approach represents a sustainable way to valorize and transform aquaculture and canning industries’ mineral waste (shells) in highly demanded osteoinductive materials.

Whole exome sequencing of multi-regions reveals tumor heterogeneity in Opisthorchis viverrini-associated cholangiocarcinoma

A texture guided transmission line image enhancement method

A new design technique and realization of gysel power dividers in substrate integrated waveguide for Ku-band applications

Effects of metal oxide catalysts on polycyclic aromatic hydrocarbons emissions from large scale biomass pyrolysis

UVB-induced HaCat cell damage and Myricaria Paniculata’s molecular effects

Shifts in sex-specific immune gene expression in a beetle with parental care

Abstract Males and females generally differ in resource investment strategies in order to maximise reproductive output. These strategies involve the control of important systemic processes such as self-maintenance and immune activity, which in turn could be traded-off against aspects of reproduction in a sex-specific manner. While some aspects of this immunomodulation have been previously shown in domestic animals, sex-specific immune modulation using repeated sampling over the breeding period has rarely been tested in the wild. Here we used Lethrus apterus, a sexually dimorphic beetle with parental care, to investigate the association between sex roles (e.g. offspring provisioning) and sex-specific immune gene expression. By determining the immune gene activation of males and females at five successive moments within the active season, we found that their sex-specific immune gene expression varies substantially across the active season, alternating between male bias to female bias and vice versa. Though, when pooling all sampling dates together, there was no overall difference in the number of up-regulated immune genes between the sexes. Sex roles in this beetle are associated with energetically demanding behaviours that could potentially explain our results. We highlight the importance of successive sampling protocols to understand ecological dynamics in the wild.

Race course characteristics are the most important predictors in 48 h ultramarathon running

Short-term cone beam CT study on bone mass changes post touch-controlled minimally invasive mandibular molar implant

Crack evolution and energy conversion characteristics of coal under acid corrosion conditions

Characteristics of cell adhesion molecules expression and environmental adaptation in yak lung tissue

Abstract Cell Adhesion Molecules (CAMs) play a crucial role in regulating immune responses and repairing damage caused by hypoxia. However, the relationship between the expression characteristics of CAMs in yak lung tissues and their adaptation to the plateau environment remains unclear. To address this question, we compared lung tissues from yaks and cattle at the same altitude. After digesting the lung tissues with trypsin or Type I collagenase for varying durations, we observed that fewer cells were isolated from yak tissues compared to cattle. RNA sequencing (RNA-seq) analysis revealed that the Differentially Expressed Genes (DEGs) in lung tissues of yaks and cattle were significantly enriched in cell adhesion-related pathways. Quantitative real-time PCR (qRT-PCR) further identified changes in the expression levels of five distinct types of CAMs. Among these, the cadherin family (CDH1, CDH2, CDH11, PCDH12, CD34) exhibited significantly higher expression in yaks than in cattle. These cadherins play a critical role in regulating lung inflammation and maintaining the alveolar-capillary barrier, thereby ensuring the structural stability of the lungs. Immunohistochemical staining demonstrated that the expression patterns of cell adhesion-related proteins (CDH1, CDH11, ITGB6, SELP, CD44) were largely consistent with the qRT-PCR results. In conclusion, compared to cattle, the enhanced cell adhesion capacity of yak lung tissues contributes to their superior adaptation to the harsh plateau environment.

Identification of UBA7 expression downregulation in myelodysplastic neoplasm with SF3B1 mutations

Abstract SF3B1 gene mutations are prevalent in myelodysplastic syndrome (MDS) and define a distinct disease subtype. These mutations are associated with dysregulated genes and pathways, offering potential for novel therapeutic approaches. However, the aberrant mRNA alternative splicing landscape in SF3B1-deficient MDS cells remains underexplored. In this study, we investigated the influence of SF3B1 gene alterations on the pre-mRNA splicing landscape in MDS cells using transcriptomic data from two independent MDS cohorts. we identified over 5000 significant differential alternative splicing events associated with SF3B1 mutation. This work corroborates previous studies, showing significant enrichment of MYC activity and heme metabolism in SF3B1 mutant cells. A key novel finding of this study is the identification of a gene expression signature driven by SF3B1 mutations, centered on protein post-translational modifications. Notably, we discovered aberrant alternative splicing of the tumor suppressor gene UBA7, leading to significantly reduced gene expression. This dysregulation implicates UBA7 as a critical player in MDS pathogenesis. Importantly, the clinical relevance of this finding is underscored by the observation that low UBA7 gene expression was associated with poor overall survival in chronic lymphocytic leukemia (CLL), another hematological malignancy with frequent SF3B1 mutations. Furthermore, a similar association between low UBA7 gene expression and poor survival outcomes was observed across multiple tumor types in the TCGA database, highlighting the broader implications of UBA7 dysregulation in cancer biology. These findings provide new insights into the mechanisms by which SF3B1 mutations reshape the pre-mRNA splicing landscape and drive disease pathogenesis in MDS. Furthermore, they underscore the potential of UBA7 as a biomarker to stratify SF3B1-mutant MDS and CLL patients, offering a refined approach for risk assessment and highlighting opportunities for targeted therapeutic interventions.