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A platform for personalized ASO therapeutics

Reversing lysosomal dysfunction to treat PAH

Proximal cysteine residues in proteins promote Nε-carboxyalkylation of lysine residues by α-dicarbonyl compounds

Androgen membrane receptor modulates muscle strength

A conserved phosphorylation mechanism for regulating the interaction between the CMG replicative helicase and its forked DNA substrate

Targeting HNRNPA2B1 to overcome chemotherapy resistance in gastric cancer stem cells: Mechanisms and therapeutic potential

Enlargement of microvascular dropout toward the disc-fovea axis indicates new central visual field defect in glaucoma

Declining activity of serum response factor in aging aorta in relation to aneurysm progression

Children’s gendered expectations of moral parties

Antimicrobial peptides selectively target malaria parasites by a cholesterol-dependent mechanism

Physiological regulation underlying the alleviation of cadmium stress in maize seedlings by exogenous glycerol

Abstract Cadmium (Cd) contamination in maize poses a significant threat to global food security due to its persistent accumulation in crops. In this study, the effects of foliar application of glycerol on Cd accumulation in maize seedlings were studied. Our results demonstrated that under Cd treatment, biomass, total chlorophyll content, net photosynthetic rate (Pn), Ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) activity, Phosphoenolpyruvate carboxylase (PEPC) activity, sucrose levels, and carbohydrate levels in maize seedlings significantly increased after glycerol application. H2O2 and MDA levels in both the aboveground and belowground portions of the maize plants significantly decreased. Moreover, superoxide dismutase (SOD), peroxidase (POD), and catalase (CAT) activities in the aboveground parts significantly increased. Notably, maize plants used glycerol to chelate Cd, which was fixed within the cell wall and soluble fraction of the roots, reducing Cd transport to the shoots and significantly lowering the Cd transport coefficient (TF). Transcriptomic data suggested that glycerol-mediated alleviation of Cd stress in maize seedlings may be associated with phenylpropanoid biosynthesis, plant-pathogen interactions and photosynthesis pathways. These molecular patterns align with the observed physiological improvements. This study provided a novel approach to effectively alleviate excessive Cd in maize and suggested possible applications of glycerol in cultivating plant resistance to heavy metals.

The E3 ubiquitin ligase RNF126 facilitates quality control of unimported mitochondrial membrane proteins

Construction of reliable QSPR models for predicting the impact sensitivity of nitroenergetic compounds using correlation weights of the fragments of molecular structures

Methionine cycle inhibition disrupts antioxidant metabolism and reduces glioblastoma cell survival

Quantitative analysis of drug–drug interactions among active components of Xuebijing in inhibiting LPS-induced TLR4 signaling and NO production

A combination of alveolar type 2–specific p38α activation with a high-fat diet increases inflammatory markers in mouse lungs

Influence of decompression surgery on sagittal balance parameters in patients with lumbar spinal stenosis

Cardioprotective effect of genetic ablation of the G-protein-coupled receptor kinase GRK2 in adult pancreatic β-cells during high-fat diet

Orbital Hall conductivity in a Graphene Haldane and Haldane Haldane bilayers

Characterization of a rhodopsin-phosphodiesterase from Choanoeca flexa to be combined with rhodopsin-cyclases for bidirectional optogenetic cGMP control