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A recent large-scale intraspecific IR expansion and evolutionary dynamics of the plastome of Peucedanum japonicum
The predictive value of combined insulin resistance and β-cell secretion in Yemeni school-aged children for type 2 diabetes mellitus
When Diversity Goals Meet Multiregional Trials
DNA promoter task-oriented dictionary mining and prediction model based on natural language technology
The usefulness of automated high frequency ultrasound image analysis in atopic dermatitis staging
Machine learning-based technique for gain prediction of mm-wave miniaturized 5G MIMO slotted antenna array with high isolation characteristics
NEJM at ESC — Asundexian versus Apixaban in Patients with Atrial Fibrillation
Biochemical properties and substrate specificity of GOB-38 in Elizabethkingia anophelis
Layer dependent thermal transport properties of one- to three-layer magnetic Fe:MoS2
Raiding nature’s genetic toolbox for UV-C resistance by functional metagenomics
AbstractAs we assess the habitability of other worlds, we are limited by being able to only study terrestrial life adapted to terrestrial conditions. The environments found on Earth, though tremendously diverse, do not approach the multitude of potentially habitable environments beyond Earth, and so limited terrestrial adaptive capabilities tell us little about the fundamental biochemical boundaries of life. One approach to this problem is to use experimental laboratory evolution to adapt microbes to these novel environmental conditions. This approach can be dramatically improved through functional metagenomics, large-scale introduction of foreign genetic material to screen for phenotypes in a new host organism. This takes advantage of Earth’s immense biological diversity with high-throughput screening for genetic tools that can facilitate adaptation. We address a key gap in functional metagenomics work by exploring the impact of the experimental parameters chosen for functional metagenomics libraries. Experimental design dictates both fragment size and copy number, and we show that both can have outsized effects on the resultant phenotypes in non-intuitive ways. These results highlight the potential of functional metagenomics for adapting life rapidly to challenging new environments, with important implications in both astrobiology and bioindustry, while also emphasizing the impacts of decisions in experimental design.
Transitional Justice — A Politico-Legal Approach to Health Equity
Employing a low-code machine learning approach to predict in-hospital mortality and length of stay in patients with community-acquired pneumonia
Quantitative analysis of choroidal vascular structures and anatomical changes in pachychoroid spectrum diseases using ultra-widefield SS-OCTA
Learning to hear again with alternating cochlear frequency allocations
Interleaved quartic high gain DC–DC converter
Abstract This research paper presents a high-gain DC–DC converter with ultra-step-up voltage gain capability. The proposed converter is synthesized from a two-phase interleaved boost converter (IBC), and its voltage gain is doubled by adopting a voltage lift capacitor. To enhance its voltage gain capability, a floating capacitor-based gain extension cell is adopted subsequently. This cell yields a voltage gain that is cubed times the output voltage obtained from a classical boost converter (CBC). By cascading the two stages, the voltage gain of the proposed converter is enhanced to quartic times (4th power) that of the CBC. The proposed gain extension concept is validated by conducting practical experiments on a 16 V to 400 V, 150 W prototype version. Practically, the prototype converter delivers 150 W to the load and operates at a full-load efficiency of 92.7% when its switches are operated at safe duty ratio values. Under dynamic conditions, the proposed converter regulates the output voltage to 400 V quickly over a wide range of input voltage and load current variations; the overshoots and undershoots are also negligible. The maximum voltage gain of the proposed converter momentarily increases to 37 when the input voltage is drastically reduced to 10.8 V while the switches are still operated at safe duty ratio values. The voltage stress on the semiconductor devices is only a fraction of the output voltage due to the hybrid voltage gain extension technique. The input current is also ripple-free as the switches in the IBC structure are always operated at a duty ratio of 50%, and only the third switch is controlled to meet the required voltage gain. The salient features of the proposed converter are clearly highlighted by comparing it with several converters that possess quadratic, cubic, and quartic voltage gain functions. The common-ground connection between the source and the load in the proposed converter is an added preferable feature for PV applications.