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Multilevel support-assisted prototype optimization network for few-shot medical segmentation of lung lesions

Scientific Reports Yuan Tian, Yongquan Liang, Yufeng Chen et al. Jan 26, 2025 DOI: 10.1038/s41598-025-87829-4

Exploring the expression of DLL3 in gastroenteropancreatic neuroendocrine neoplasms and its potential diagnostic value

Scientific Reports L. Yin, R. Wang, X. Ma et al. Jan 26, 2025 DOI: 10.1038/s41598-025-86237-y

An approach to energy conservation in lighting systems using luminaire-based sensor for automatic dimming

Scientific Reports Chaiyan Jettanasen, Surakit Thongsuk, Chayanut Sottiyaphai et al. Jan 26, 2025 DOI: 10.1038/s41598-025-87813-y

Synchrotron XRF spectroscopy for reading salt-encrusted cuneiform tablets

Scientific Reports Mirko Surdi, Pieter Tack, Sylvia Lycke et al. Jan 26, 2025 DOI: 10.1038/s41598-024-84394-0

Association between ABCB4 variants and intrahepatic cholestasis of pregnancy

Scientific Reports Dekun Zhang, Yuhong Li, Shufeng He et al. Jan 26, 2025 DOI: 10.1038/s41598-025-87909-5

Preparation of curcumin submicron particles by supercritical antisolvent method with external adjustable annular gap nozzle

Scientific Reports Yechen Wang, Zirui Li, Sun Fayu et al. Jan 26, 2025 DOI: 10.1038/s41598-025-87787-x

Novel transcripts of EMT driving the malignant transformation of oral submucous fibrosis

Scientific Reports Smitha Sammith Shetty, Kanaka Sai Ram Padam, Mohit Sharma et al. Jan 26, 2025 DOI: 10.1038/s41598-025-87790-2

Abstract Oral submucous fibrosis (OSF) is a chronic, progressive, and fibrotic condition of the oral mucosa that carries an elevated risk of malignant transformation. We aimed to identify and validate novel genes associated with the regulation of epithelial-to-mesenchymal transition (EMT) in OSF. Genes regulating EMT were identified through differential gene expression analysis, using a LogFC threshold of -1 and + 1 and a padj value < 0.05, based on data from GEO datasets and the TCGA-HNSC datasets. The curated EMT genes were correlated with functional cancer states and subjected to clustering to identify candidate genes. Integration of bioinformatics and proteomics led to the discovery of the EMT genes MMP9, SPARC, and ITGA5 as novel candidates. Comprehensive pathway and immunohistochemical analyses confirmed their roles in regulating EMT in OSF, oral squamous cell carcinoma (OSCC), and OSF-associated squamous cell carcinoma (OSFSCC). The significant roles of MMP9, SPARC, and ITGA5 in fibrosis and malignancy suggest a novel mechanism in which fibrosis-associated type 2 EMT undergoes transition to type 3 EMT, driving OSF towards malignancy.

Empowering wastewater treatment with step scheme heterojunction ternary nanocomposites for photocatalytic degradation of nitrophenol

Scientific Reports Zhu Liu, Mah Roosh, Ming Lu et al. Jan 26, 2025 DOI: 10.1038/s41598-025-86975-z

Association between frailty index and mortality in depressed patients: results from NHANES 2005–2018

Scientific Reports Xiaoqiang Liu, Yubin Wang, Yingxuan Huang et al. Jan 26, 2025 DOI: 10.1038/s41598-025-87691-4

Unveiling the biological activities of Heliotropium indicum L. plant extracts: anti-inflammatory activities, GC–MS analysis, and in-silico molecular docking

Scientific Reports Mst. Sadia Afroz Shoily, Md. Ekramul Islam, Nur Mohammad Rasel et al. Jan 26, 2025 DOI: 10.1038/s41598-024-79559-w

Flood change detection model based on an improved U-net network and multi-head attention mechanism

Scientific Reports Fajing Wang, Xu Feng Jan 26, 2025 DOI: 10.1038/s41598-025-87851-6

A comprehensive analysis of trends in the burden of gout in China and globally from 1990 to 2021

Scientific Reports Shiwei Xie, Heng Xiao, Lei Xu et al. Jan 26, 2025 DOI: 10.1038/s41598-025-86090-z

Interactions between DASH-style diet and ADIPOQ and ARL15 genes polymorphisms on blood pressure and central obesity in Iranian adults

Scientific Reports Mehdi Mollahosseini, Zeinab Yazdanpanah, Azadeh Nadjarzadeh et al. Jan 26, 2025 DOI: 10.1038/s41598-025-87567-7

Association of liver fibrosis with aneurysm size and mortality risk in patients undergoing open abdominal aortic aneurysm repair

Scientific Reports Mohamad Jamalinia, Seyed Alireza Mirhosseini, Maryam Ranjbar et al. Jan 26, 2025 DOI: 10.1038/s41598-025-88133-x

Extreme migratory connectivity and apparent mirroring of non-breeding grounds conditions in a severely declining breeding population of an Afro-Palearctic migratory bird

Scientific Reports Máire Kirkland, Nathaniel N. D. Annorbah, Lee Barber et al. Jan 26, 2025 DOI: 10.1038/s41598-025-86484-z

Chain-mediated effect of physical activity between Chinese language-based L2 motivational self-system and intended effort

Scientific Reports Zixia Bu, Yu Liu, Yi Ba et al. Jan 26, 2025 DOI: 10.1038/s41598-025-86517-7

Evaluating solar power plant sites using integrated GIS and MCDM methods: a case study in Kermanshah Province

Scientific Reports Iman Zandi, Aynaz Lotfata Jan 26, 2025 DOI: 10.1038/s41598-025-87476-9

Predictive nomogram for postoperative lower-limb deep vein thrombosis in patients undergoing endoscopic endonasal surgery during hospitalization: a retrospective cohort study

Scientific Reports Hai Peng, Ruofei Yuan, Zhe Zhang et al. Jan 25, 2025 DOI: 10.1038/s41598-025-87656-7

Identification of a novel TOP2B::AFF2 fusion gene in B-cell acute lymphoblastic leukemia

Scientific Reports Tao Liu, Yang Wang, Xi-Zhou An et al. Jan 25, 2025 DOI: 10.1038/s41598-025-86865-4

Berberine decorated zinc oxide loaded chitosan nanoparticles a potent anti cancer agent against breast cancer

Scientific Reports Fatemeh Esnaashari, Hojjatolah Zamani, Hossein Zahmatkesh et al. Jan 25, 2025 DOI: 10.1038/s41598-025-87445-2