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A multi-objective optimization framework for EV-integrated distribution grids using the hiking optimization algorithm
Exclusive: Trump team freezes new NSF awards — and could soon axe hundreds of grants
Enhanced anomaly network intrusion detection using an improved snow ablation optimizer with dimensionality reduction and hybrid deep learning model
Four-Ce:Nd:YAG-rod solar laser with 4.49% conversion efficiency through Fresnel lens
Author Correction: Controlled patterning of crystalline domains by frontal polymerization
Improved approximate check polytope projection algorithm of ADMM penalized decoding for LDPC codes in IoTs
Meet the researchers pioneering Spanish climate solutions
Biodiversity declines across fragmented forests
Association between relative fat mass and female infertility among reproductive-aged women from NHANES 2013–2020
In vitro antidiabetic and antioxidant activities of protein hydrolysates via alkaline autolysis of Fusarium venenatum mycoprotein
Perception and argumentation in the LK-99 superconductivity controversy: a sentiment and argument mining analysis
Abstract The announcement of LK-99 as a potential room-temperature, ambient-pressure superconductor sparked widespread debate across both traditional news outlets and social media platforms. This study investigates public perceptions and argumentation patterns surrounding LK-99 by applying sentiment analysis and computational argument mining to a diverse dataset. We analyzed 797 YouTube videos, 71,096 comments, and 1,329 news articles collected between 2023 and 2024. Our results reveal distinct sentiment trajectories: while news articles and YouTube posts exhibit fluctuating yet predominantly positive tones, user comments consistently maintain a more negative sentiment. Discourse analysis shows that structured argumentation—especially reasoning based on expert opinions, observable signs, and anticipated consequences—is prevalent in professionally curated content, whereas a significant proportion of user comments lack identifiable argumentation schemes. Moreover, channel-level analysis indicates that non-expert channels, despite their limited specialization in science, attract higher audience engagement than traditional science channels. These findings highlight the complexities of digital science communication and underscore the need for adaptive strategies that bridge the gap between expert evidence and public discourse. Our study provides practical recommendations to enhance public understanding of scientific advancements in digital spaces.
Japan’s big bet on stem-cell therapies might soon pay off with medical breakthroughs
Author Correction: Isoprene nitrates drive new particle formation in Amazon’s upper troposphere
A prospective study on enhanced recovery of Mycobacterium tuberculosis from children’s stool using novel power ultrasound decontamination
A. J. Eisfeld et al. reply
Evaluation of renal function with neutrophil gelatinase-associated lipocalin in patients with ıron deficiency anemia
Effects of combined high-intensity interval and moderate-intensity continuous training vs. moderate-intensity continuous training alone in male adolescents: a randomized controlled trial
Hepatic stellate cells control liver zonation, size and functions via R-spondin 3
Abstract Hepatic stellate cells (HSCs) have a central pathogenetic role in the development of liver fibrosis. However, their fibrosis-independent and homeostatic functions remain poorly understood1–5. Here we demonstrate that genetic depletion of HSCs changes WNT activity and zonation of hepatocytes, leading to marked alterations in liver regeneration, cytochrome P450 metabolism and injury. We identify R-spondin 3 (RSPO3), an HSC-enriched modulator of WNT signalling, as responsible for these hepatocyte-regulatory effects of HSCs. HSC-selective deletion of Rspo3 phenocopies the effects of HSC depletion on hepatocyte gene expression, zonation, liver size, regeneration and cytochrome P450-mediated detoxification, and exacerbates alcohol-associated and metabolic dysfunction-associated steatotic liver disease. RSPO3 expression decreases with HSC activation and is inversely associated with outcomes in patients with alcohol-associated and metabolic dysfunction-associated steatotic liver disease. These protective and hepatocyte-regulating functions of HSCs via RSPO3 resemble the R-spondin-expressing stromal niche in other organs and should be integrated into current therapeutic concepts.