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Zero bias conductance peak related to spin triplet states in noncollinear magnetized graphene superconducting junctions
Symmetries of Weyl superconductors with different pairings
Bacillus aryabhattai CKNJh11 as a promising probiotic improves growth performance and egg quality in laying hens
Serum extracellular matrix biomarkers in rheumatoid arthritis, psoriatic arthritis and psoriasis and their association with hand function
Abstract Inflammatory arthritis, including rheumatoid arthritis and psoriatic arthritis, is characterized by physical function impairment. This becomes apparent even before arthritis onset, as in psoriasis (PsO). Chronic inflammation triggers an accelerated remodeling of the extracellular matrix (ECM), resulting in released ECM fragments detectable in blood. We aimed to investigate levels of blood-based ECM biomarkers in patients with RA, PsA, PsO, and healthy controls and to explore the association of ECM biomarkers with hand function impairments. Patients with RA (n = 85), PsA (n = 115), PsO (n = 102) and controls (n = 110) were included in this cross-sectional study. ECM catabolic (C1M, C2M, C3M, C4M, PRO-C4, C6M, ARG), formation (PRO-C1, PRO-C3, PRO-C6) and inflammation biomarkers (VICM) were measured in serum from all patients. Objective hand function (fine motor skills (Moberg-Picking-Up Test), isometric grip strength (dynamometer) and patient-perceived hand function (Michigan Hand Questionnaire (MHQ)) were assessed. Patients with RA and PsA received treatment with disease-modifying anti-rheumatic drugs. VICM levels were higher in RA, PsA, and PsO than in controls (p < 0.0001). PsA and PsO showed higher C4M levels compared to controls (p < 0.0001, p < 0.0001), while C6M was lower in patients with RA, PsA and PsO than in controls (p < 0.0001, p < 0.001, p < 0.01). PsO presented with higher levels of C1M compared to controls and to RA (p < 0.001 and p < 0.0001). PRO-C6 correlated negatively with MHQ (ρ = -0.39, p < 0.01) and grip strength (ρ = -0.31, p < 0.05) in PsO, while only weak correlations were observed between biomarkers and hand function scores for RA and PsA patients (all ρ < ± 0.2–0.3). Patients with RA, PsA, and PsO showed significant alterations in ECM remodeling biomarkers. Especially PsA and PsO had higher levels of inflammatory biomarkers compared to RA and controls, likely due to modulation by treatment. Predominantly in PsO, ECM formation biomarkers were associated with hand function impairments.
Calculation of hydrogen dispersion in cushion gases using machine learning
New binary and ternary SiO2 composites with Fe2O3 and Co2.74O4 and the evaluation of their γ-radiation shielding properties
Abstract A new series of binary and ternary nanocomposites contains cobalt oxide or iron/cobalt oxides were manufactured to increase silicon dioxide $$\gamma$$ shielding power. XRD indicated the presence of Co as Co2.74O4 (COD: 1528446) and the presence of iron as Fe3O4 (COD: 9002318 and 9005814). Using Profex, the Rietveld refinements were carried out. The Rw, Rex, x2, and Gof were 4.49, 4.34, 1.07, and 1.03, respectively, indicating good refinement parameters. XPS indicated the presence of Si ( $$\hbox {Si}^{4+}$$ ), Fe (Fe $$_{2}$$ O $$_{3}$$ ) and cobalt ( $$\hbox {Co}^{2+}$$ and $$\hbox {Co}^{3+}$$ ). TEM analysis showed that all metal oxide@SBA-15 solids have characteristic and well-organized SBA-15 structures. The $$\gamma$$ -radiation shielding for the prepared samples were investigated via the Monte-Carlo code (MCN) and Phy-X software. The results confirmed that, adding high concentrations of cobalt-oxide and hematite increases the linear attenuation significantly. The SiCoFe-3 sample, which contains the highest content of cobalt-oxide and hematite, has the best $$\gamma$$ -radiation shielding capability among all the synthesized SiCo/SiCoFe samples.
Stability analysis, $$\:{\varvec{\phi\:}}^{6}$$ model expansion method, and diverse chaos-detecting tools for the DSKP model
Deciphering the prognostic significance of WDR77 in gliomas: a comprehensive analysis
Fault prediction of aircraft engine based on adaptive hybrid sampling and BiLSTM
Breeding progress is a major contributor to improved regional maize water productivity
Antioxidant and anti-inflammatory effects of Equisetum arvense L. on acid-induced ulcerative colitis in rats
CFTR acts as a potential therapeutic target for attention deficit-hyperactivity disorder
Spatial regulation of chrysosplenetin on amino acid homeostasis linked to artemisinin resistance in Plasmodium berghei K173 based on targeted metabolomics
Development of a novel multiepitope vaccine against Menangle virus (MenV) using in-silico approaches by targeting its transmembrane proteins
Facets of shame and their impact on quality of life in patients with atopic dermatitis and psoriasis
Abstract Shame is a complex emotion with different facets. Skin shame is a specific aspect of body shame, which involves the skin perceived as inferior or flawed. Its role in atopic dermatitis (AD) and psoriasis is not well investigated. This explorative study pursued three objectives: First, the comparative analysis of shame and its facets in AD and psoriasis. Second, analysis of the association of skin shame with other shame facets, depression, and anxiety. Third, exploration of the unique impact of shame and its different facets on quality of life (QoL) in AD and psoriasis patients. This cross-sectional online survey encompassing German-speaking patients included several self-report measures on skin and general shame, depression, and anxiety as well as the Dermatology Life Quality Index (DLQI), Patient-Oriented Eczema Measure (POEM), and Psoriasis Symptoms and Signs Diary (PSSD). Data from 413 adult participants with AD ( N = 162) or psoriasis ( N = 251) were analyzed. There were no significant differences in skin or general shame, depression, or anxiety between those with AD or psoriasis. Skin shame as well as other aspects of shame were associated with younger age, female sex, depression, anxiety, and QoL. Analysis of AD and psoriasis subsamples revealed significant correlations of disease severity with skin shame, depression, anxiety, and DLQI. Hierarchical linear regression analyses indicated that skin shame was the second most important determinant of QoL after self-assessed disease severity. Systematic consideration of shame in AD and psoriasis is necessary in order to effectively reduce disease burden and enhance QoL.
Design and fabrication of a LEG based stretchable piezoresistive acoustic pressure sensor for ultra low pressures
Beam management for millimeter-wave mobile communications based on digital twin-enabled scenario cognition
Leveraging vision transformers and entropy-based attention for accurate micro-expression recognition
Bacteroides maternus sp. nov., a novel species isolated from human faeces
Abstract A novel bacterial strain, MSB163, was isolated from the stool sample of a healthy mother, 4 weeks after giving birth via vaginal delivery. Taxonomic identification tools revealed that MSB163 belongs to the genus Bacteroides, but it is distinct from any currently known species. The closest related species is Bacteroides cellulosilyticus strain BFG- 250, with an average nucleotide identity (fastANI) of 94.51%. The genome length of MSB163 is 6,440,948 bp and the GC content 42.95%. Two plasmids were identified in the whole genome sequence. MSB163 is a Gram-negative, rod-shaped, non-motile anaerobic bacterium. The optimum growth conditions were at 37 °C, pH 7 and 0% (w/v) NaCl. The respiratory quinones were the menaquinones MK- 10 and MK- 11 and C15:0 ANTEISO was the major fatty acid. The predominant polar lipids were phosphatidylethanolamine, diphosphatidylglycerol and phospholipid. According to the taxonomic results and physiological analysis, strain MSB163 represents a novel species of the genus Bacteroides, for which we propose the name Bacteroides maternus, since the type strain was isolated from the stool sample of a mother. B. maternus type strain (MSB163) sequencing can be accessed under the biosample ID SAMN3953129 on NCBI. The strain was deposited on BCCM/LMG Bacteria Collection under the accession number LMG 33,374 and Leibniz Institut DSMZ GMBH under the accession number DSM 117,047.