Browse Articles
Discover research articles across all indexed journals
Publisher Correction: Perception and adaptation of receptive prosody in autistic adolescents
The clinical significance of an AI-based assumption model for neurocognitive diseases using a novel dual-task system
Comprehensive life cycle assessment of 25 furniture pieces across categories for sustainable design
Periostin-mediated activation of NF-κB signaling promotes tumor progression and chemoresistance in glioblastoma
Multi-omics analysis constructs a novel neuroendocrine prostate cancer classifier and classification system
Exploring the comorbidity association and biological mechanisms of chronic rhinosinusitis and chronic obstructive pulmonary disease
Mechanism research for influence of steel slag on shape transformation of perovskite crystals
Interleukin-7 promotes porcine early embryogenesis in vitro and inner cell mass development through PI3K/AKT pathway after parthenogenetic activation
Abstract Interleukin-7 (IL-7) plays a crucial role in cell survival and proliferation through the phosphatidylinositol-3-kinase (PI3K)/AKT signaling. While we previously demonstrated the beneficial role of IL-7 in early porcine embryonic development, the underlying molecular mechanisms remained unclear. We hypothesized that IL-7 would enhance early embryogenesis and promote inner cell mass (ICM) formation via PI3K/AKT pathway activation. To test this, embryos were cultured with wortmannin (Wort), a PI3K inhibitor, with or without IL-7 after parthenogenetic activation. IL-7 supplementation significantly increased cleavage and blastocyst formation rates compared to the control (p < 0.05), while mitigating Wort-induced developmental impairment. Moreover, IL-7 significantly reduced blastocyst apoptosis and increased total cell numbers compared to the control (p < 0.05), thereby counteracting pro-apoptotic effects of Wort. Furthermore, IL-7 treatment significantly promoted ICM formation through the PI3K/AKT pathway, as demonstrated by increased SOX2 + cell numbers and ICM-specific gene expression, with elevated phosphorylated AKT levels compared to the control (p < 0.05). Notably, IL-7 significantly improved mitochondrial function and biogenesis-related gene expression compared to the control (p < 0.05) through a PI3K/AKT-independent pathway. These findings suggest that IL-7-mediated PI3K/AKT signaling enhances porcine early embryonic development in vitro, providing insights into mechanisms that regulate early embryonic development in mammals.
Antimicrobial resistance and etiological dynamics affected by tropical climate variability on year-round diagnosis of upper respiratory infections in companion rabbits with snuffles
Performance assessment of thermal energy storage system for solar thermal applications
Exploring the effect of SGLT2 inhibitors on the risk of primary open-angle glaucoma using Mendelian randomization analysis
Predictors of self-management behaviors among patients undergoing hemodialysis
Study on the evaluation of workface wall stability based on cloud model
Predicting peak particle velocity in pre-splitting of gas-producing devices using improved particle swarm optimization algorithm
Implications of spatial and seasonal air pollution patterns, socioeconomic disparities, and 15-minute communities for achieving WHO air quality guidelines
Abstract Achieving WHO air pollution guidelines is critical to reduce the health burden of air pollution, which disproportionately affects socioeconomically disadvantaged populations and varies by sector, spatial distribution, and seasonal trends. This study explores the implications of sectorial and spatial-seasonal air pollution patterns, socio-economic disparities, and 15-minute communities to achieve (2021) WHO air quality guidelines for PM2.5 and NO2. The study analyses spatial-temporal patterns of air pollution in Belgium. Seasonal air pollution exposure is assessed through summer-to-winter ratios, stratified by land cover, urbanisation, and proximity to roads, and linked to socio-economic disparities using LOESS regression. A case study evaluates the mitigation potential of 15-minute communities for traffic-related air pollution, leveraging the Mobiscore tool to explore the relationship between accessibility and car ownership, a proxy for traffic-related emissions. NO2 and PM2.5 show marked seasonal and spatial variations, with higher concentration ratios in summer near busy roads and urban centres, especially for NO2. In general the NO2 spatial-seasonal pattern is more heterogenous compared to the PM2.5 pattern. Winter pollution exposure significantly hampers meeting WHO health targets, although summer levels of NO2 remain high around major traffic routes. The observed disparities in exposure to NO₂ highlight significant socio-economic inequalities, with the most deprived populations disproportionately burdened by traffic-related air pollution. The results from our case-study to mitigate traffic-related air pollution demonstrate that, up to a Mobiscore of 8.0, car ownership remains constant with increasing availability of services and public transport. From a turning point Mobiscore of 8.0, car ownerships starts to drop significantly, indicating that improving Mobiscores to very high scores ( > = 8.0) may lead to reduced car ownership and lower NO2 and PM2.5 emissions and exposure. Our study highlights important spatial-seasonal patterns in air pollution and their health implications, emphasizing the need for season-specific and structural traffic interventions to meet WHO guidelines for PM2.5 and NO2 exposure. A case study on mitigating traffic-related air pollution identifies a threshold where sufficient public transport and service accessibility lead to a reduction in car ownership. Addressing socio-economic disparities is crucial, as these areas often face greater challenges in meeting WHO air pollution guidelines, particularly for NO₂.