Browse Articles

Symmetric adenine methylation is an essential DNA modification in the early-diverging fungus Rhizopus microsporus

Lymphatic flow dynamics under exercise load assessed with thoracic duct ultrasonography

Abstract The thoracic duct (TD) is the largest lymphatic vessel proximal to the venous system. It undergoes morphological changes in response to lymph flow from the periphery, with automatic contraction controlling the dynamics to propel lymph toward the venous system. Recent advancements in ultrasonography have facilitated non-invasive observations of the TD’s terminal, including its valve and wall motions. Observations of TD movements allow predictions of lymphatic flow dynamics. However, no studies have yet documented the changes in the TD under exercise-induced lymph flow enhancement in humans. Here, using 18-MHz high-frequency ultrasonography, we demonstrate for the first time that the TD diameter significantly expands under exercise load. This study analyzed 20 participants; the maximum TD diameters at rest and post-exercise were 2.69 ± 1.06 mm and 3.41 ± 1.32 mm, respectively (p = 0.00000056). While various methods exist for observing the TD, our approach—dynamically monitoring the TD diameter using sonography in real time and correlating it with lymphatic flow dynamics—offers a novel contribution.

Modular chiral origami metamaterials

EvoWeaver: large-scale prediction of gene functional associations from coevolutionary signals

Constructing machine learning-based risk prediction model for osteoarthritis in population aged 45 and above: NHANES 2011–2018

Oxygen spillover on supported Pt-cluster for anti-CO-poisoning hydrogen oxidation

Neurodynamic robust adaptive UWB localization algorithm with NLOS mitigation

Randomly oriented covalent organic framework membrane for selective Li+ sieving from other ions

Generation driven understanding of localized 3D scenes with 3D diffusion model

Author Correction: Deep reinforcement learning for active flow control in a turbulent separation bubble

Predicting outcomes following open abdominal aortic aneurysm repair using machine learning

Photoactuating artificial muscle from supramolecular assembly of an overcrowded alkene-derived molecular switch

Abstract The amplification of molecular motion along length scales for macroscopic muscle-like functions, based on supramolecular polymers, provides attractive opportunities ranging from soft actuators to responsive biomedical materials. Taking the challenge to reveal dynamic assembly parameters governing muscle functions, we present the design of a photoswitch amphiphile based on an overcrowded alkene-derived core, and developed supramolecular artificial muscles. Going from molecular motor amphiphile (MA) to switch amphiphile (SA), taking advantage of high thermal stability of the switch core, a self-recovering of bent SA artificial muscle is observed in post-photoactuation without external intervention. Eliminating molecular motions in SA artificial muscle during the post-photoactuation and aging process enables us to identify correlations between dynamic assembly transformations and macroscopic actuating functions. These findings provide insights into photoactuation and subsequent self-recovery mechanisms from the aspect of dynamic assembly process, which offers new opportunities for developing amphiphile-based supramolecular artificial muscles.

TCAINet an RGB T salient object detection model with cross modal fusion and adaptive decoding

TRIM52 maintains cellular fitness and is under tight proteolytic control by multiple giant E3 ligases

Abstract Tripartite motif 52 (TRIM52) exhibits strong positive selection in humans, yet is lost in many other mammals. In contrast to what one would expect for such a non-conserved factor, TRIM52 loss compromises cell fitness. We set out to determine the cellular function of TRIM52. Genetic and proteomic analyses revealed TRIM52 physically and functionally interacts with the DNA repair machinery. Our data suggest that TRIM52 limits topoisomerase 2 adducts, thereby preventing cell-cycle arrest. Consistent with a fitness-promoting function, TRIM52 is upregulated in various cancers, prompting us to investigate its regulatory pathways. We found TRIM52 to be targeted for ultra-rapid proteasomal degradation by the giant E3 ubiquitin ligases BIRC6, HUWE1, and UBR4/KCMF1. BIRC6 mono-ubiquitinates TRIM52, with subsequent extension by UBR4/KCMF1. These findings suggest a role for TRIM52 in maintaining genome integrity, and regulation of its own abundance through multi-ligase degradation.

An intelligent federated learning boosted cyberattack detection system for Denial-Of-Wallet attack using advanced heuristic search with multimodal approaches

Coherent energy transfer in coupled nonlinear microelectromechanical resonators

Chemogenetic inhibition of prefrontal cortex inputs to dorsal raphe reduces anxiety behaviors in male rat model of fetal alcohol spectrum disorder

Combined dynamical-deep learning ENSO forecasts

Comparing neural responses to cutaneous heat and pressure pain in healthy participants

Abstract Even though acute pain comes in many different shapes and forms, a lot of experimental pain studies predominantly employ cutaneous heat pain. This makes a comparison between different pain types and the link between findings from these experimental studies to clinical pain difficult. To bridge this gap, we investigated both cuff pressure pain and cutaneous heat pain using a within-subject design in combination with functional magnetic resonance imaging (fMRI). Noxious stimuli were applied with a 17-s duration at three different intensities above the pain threshold using a thermode and a computer-controlled cuff pressure device. Both pain modalities led to contralateral activation in the anterior insula and parietal operculum. Heat pain showed greater activation in the precentral gyrus, pontine reticular nucleus, and dorsal posterior insula, whilst pressure pain showed greater activation in the primary somatosensory cortex and bilateral superior parietal lobules. Most importantly, the time course of the fMRI signal changes differed between modalities, with pressure pain peaking in the first stimulus half, whereas heat pain led to a prolonged and increasing response across the stimulus duration with a peak in the second stimulus half. Our findings suggest that pressure and heat pain lead to common as well as different (temporal) activation patterns in key pain processing regions.

Thick-panel origami structures forming seamless surfaces